Differences in maternal and paternal age between Schizophrenia and other psychiatric disorders

López-Castromán, Jorge; Gómez, David; Carballo, Juan J.; Fernández-Navarro, Pablo; Perez‐Rodriguez, M. Mercedes; Basurte-Villamor, Ignacio; Navarrete, Francisco; Ginestar, Consuelo Morant; Currier, Dianne; Torres, Marta Reyes; Navío-Acosta, Mercedes; Sáiz-Ruiz, Jerónimo; Jiménez‐Arriero, Miguel Ángel; Baca‐García, Enrique

doi:10.1016/j.schres.2009.11.006

Cited by 57 publications

(52 citation statements)

References 25 publications

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“…Advanced maternal and paternal ages at birth were reported to be a risk factor in schizophrenia and psychosis [41]. In the present study, the mean age of the mothers of the patients with FEP was significantly higher than for the controls.…”

Section: Discussioncontrasting

confidence: 43%

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Şimşek

Gençoğlan

Yüksel³

et al. 2016

Neuropsychobiology

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Objective: Oxidative stress has been reported to play a role in the psychopathology of schizophrenia, though only a few studies have investigated the relationship between early-onset schizophrenia and oxidative stress. The aim of the present study is to evaluate the level of oxidative stress and the presence of DNA damage in first-episode psychosis (FEP) in adolescents. Methods: This study was conducted in the Department of Child Psychiatry of the Dicle University Hospital. It included 20 adolescent patients (age 11-17 years) with psychosis (acute psychosis, schizophreniform disorder, or schizophrenia) according to DSM-IV criteria who had received no previous psychiatric therapy (patient group) and 20 age/gender-matched healthy adolescents (control group). Structured psychiatric interviews [Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version (K-SADS-PL) and Positive and Negative Symptom Scale (PANSS)] were conducted on the patients, and the Clinical Global Impressions (CGI) scale was used to evaluate the severity of disease. Glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q (CoQ), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were determined using the ELISA method and commercial ELISA kits. Results: The mean age was 14.5 ± 1.6 years in the FEP group (male-to-female ratio: 8/12) and 14.4 ± 1.5 years in the control group (male-to-female ratio: 8/12). There were no differences between the patient and control groups in terms of SOD, GPx, or 8-OHdG values (p > 0.05). Conclusions: This study on DNA damage and oxidative stress in FEP in adolescents had a small sample size, and our data suggest that oxidative stress is associated with a chronic disease course rather than being an early sign of early-onset schizophrenia.

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Section: Discussioncontrasting

confidence: 43%

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Şimşek

Gençoğlan

Yüksel³

et al. 2016

Neuropsychobiology

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“…The literature reported in the latter part of this review is somewhat of a departure from the literature focused on more severe psychiatric outcomes, which holds that older maternal age may place offspring at risk for autism spectrum disorders (40), psychotic disorders (27), and bipolar disorder (30). These findings also represent a departure from existing literature suggesting that after accounting for paternal age, maternal age does not exert an independent effect on mental health outcomes in offspring (23,25).…”

Section: Discussionmentioning

confidence: 71%

“…After accounting for the effect of paternal age, maternal age has largely been found not to predict offspring risk for schizophrenia (24)(25)(26), although one study found a significant positive linear increase between increasing maternal age and risk for psychotic disorders (schizophrenia, schizotypal, and delusional disorders) (27). The authors of that study suggest that the observed relationship may be related to perinatal complications, which have been associated with both older maternal age and increased incidence of psychotic disorders (8,28,29).…”

Section: Older Maternal Age and Psychiatric Outcomes In Offspringmentioning

confidence: 92%

Older maternal age and child behavioral and cognitive outcomes: a review of the literature

Tearne

2015

Fertility and Sterility

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“…Several studies have identified the effect in large cohorts, utilizing a variety of controls (such as paternal education and SES), and a variety of cognitive ability measures (Lopez-Castroman et al, 2010;Malaspina et al, 2005;Whitley, Deary, Der, Batty, & Benzeval, 2012). Recently Arslan and co-workers (2014) examined the association in a sample of 1898 twin-singletons.…”

Section: Mutation Accumulationmentioning

confidence: 99%

How fragile is our intellect? Estimating losses in general intelligence due to both selection and mutation accumulation

Woodley

2015

Personality and Individual Differences

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Differences in maternal and paternal age between Schizophrenia and other psychiatric disorders

Cited by 57 publications

References 25 publications

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Older maternal age and child behavioral and cognitive outcomes: a review of the literature

How fragile is our intellect? Estimating losses in general intelligence due to both selection and mutation accumulation

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