Differences in liver stiffness values obtained with new ultrasound elastography machines and Fibroscan: A comparative study

Piscaglia, Fabio; Salvatore, Veronica; Mulazzani, Lorenzo; Cantisani, Vito; Colecchia, Antonio; Donato, Roberto Di; Felicani, Cristina; Ferrarini, Alessia; Gamal, N.; Marasco, Giovanni; Mazzotta, Elena; Ravaioli, Federico; Ruggieri, Giacomo; Serio, Ilaria; Nkamgho, Joules Fabrice Sitouok; Serra, Carla; Festi, Davide; Schiavone, Cosima; Bolondi, Luigi

doi:10.1016/j.dld.2017.03.001

Cited by 56 publications

(43 citation statements)

References 18 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A daily LSM assessment, which is hardly practicable in the actual clinical setting, could identify the real advantages of TE for assessing LSM. Another limitation is that in this study, we assessed LSM only by TE, and thus it is difficult to compare our findings with results obtained with other ultrasound-based elastography techniques, as demonstrated recently [44]. Nevertheless, even though a dedicated device is needed, TE is still considered the best validated and readily available elastography technique, and most centers use TE as a standard technique to assess LSM even in the consolidated hepatologic indications [38,45,46].…”

Section: Discussionmentioning

confidence: 88%

Liver Stiffness Measurement Allows Early Diagnosis of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome in Adult Patients Who Undergo Hematopoietic Stem Cell Transplantation: Results from a Monocentric Prospective Study

Colecchia

Ravaioli

Sessa

et al. 2019

Biology of Blood and Marrow Transplantation

Self Cite

View full text Add to dashboard Cite

A B S T R A C T Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a life-threatening complication affecting patients undergoing hematopoietic stem cell transplantation (HSCT). The survival rate is higher when specific therapy is initiated early; thus, improving early, noninvasive diagnosis of VOD/SOS is an important need. In an adult population undergoing HSCT, we aimed to assess the role of liver stiffness measurement (LSM), evaluated by transient elastography (TE), for diagnosing VOD/SOS. Between April 2016 and March 2018, 78 consecutive adult patients with indications for allogeneic HSCT were prospectively included. LSM was performed before HSCT and at days +9/10, +15/17, and +22/24 post-HSCT. New European Society for Blood and Marrow Transplantation criteria were used to establish VOD/SOS diagnosis. Four patients developed VOD/SOS (5.1%) during the study period, with a median time of +17 days post-HSCT. A sudden increase in LSM compared with previously assessed values and pre-HSCT values, was seen in all patients who developed VOD/SOS. LSM increases occurred from 2 to 12 days before clinical SOS/VOD appearance. The VOD/SOS diagnostic performance of increased LSM over pre-HSCT assessment showed an area under the receiver operating characteristic curve of 0.997 (sensitivity 75%; specificity 98.7%). LSM gradually decreased following successful VOD/SOS-specific treatment. Interestingly, LSM values did not increase significantly in patients experiencing hepatobiliary complications (according to the Common Terminology Criteria) other than VOD/SOS. LSM by TE can be considered a promising method to perform an early, preclinical diagnosis and follow-up of VOD/SOS.

show abstract

Section: Discussionmentioning

confidence: 88%

Liver Stiffness Measurement Allows Early Diagnosis of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome in Adult Patients Who Undergo Hematopoietic Stem Cell Transplantation: Results from a Monocentric Prospective Study

Colecchia

Ravaioli

Sessa

et al. 2019

Biology of Blood and Marrow Transplantation

Self Cite

View full text Add to dashboard Cite

show abstract

“…Results of TE, RTE and ARFI previously demonstrated that malignant FLL were generally stiffer than benign lesions; however, this evidence was obtained in relatively small studies and the used techniques are not fully capable to provide an extensive qualitative and quantitative elasticity analysis in FLL. It should be appreciated at this point that different elastographic methods should not be considered identical and that cut‐off values of liver stiffness are not interchangeable between them . Therefore, the results of one method (for example, mean stiffness and cut‐off value between benign and malignant FLL as obtained by RT‐2D‐SWE) could not be extrapolated and used as such for the other elastographic method (for example pSWE).…”

Section: Discussionmentioning

confidence: 99%

Liver elastography malignancy prediction score for noninvasive characterization of focal liver lesions

Grgurević

Bokun

Salkić

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

“…Different methods of calculating liver stiffness have the potential to yield variable results, and even among manufacturers using the same techniques, different measured values may be obtained . The work flow and data acquisition are also unalike between machines and may affect reliability, especially for an inexperienced operator.…”

mentioning

confidence: 99%

Reproducibility of 2 Liver 2‐Dimensional Shear Wave Elastographic Techniques in the Fasting and Postprandial States

Simkin¹,

Rattansingh²,

Liu

et al. 2018

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives-The purpose of this study was to compare the reliability and agreement of 2 methods of 2-dimensional (2D) shear wave elastography (SWE) on liver stiffness in healthy volunteers. We also assessed effects of the prandial state and operator experience on measurements.Methods-Two operators, 1 experienced and 1 novice, independently examined 20 healthy volunteers with 2D SWE on 2 ultrasound machines (Aixplorer [SuperSonic Imagine, Aix-en-Provence, France] and Aplio 500 [Canon Medical Systems Corporation, Otawara, Japan]). Volunteers were scanned 8 times by the operators using both machines in fasting and postprandial states. Agreement was evaluated by a Bland-Altman analysis, and the correlation was assessed by the Pearson correlation and intraclass correlation coefficients (ICCs). An analysis of variance was conducted to determine the contribution of the machine, prandial state, and operator experience to the variability.Results-Agreement assessed by Bland-Altman plots showed no statistically significant difference in measured liver stiffness between the machines (mean difference, -0.8%; 95% confidence interval, -3.7%, 2.1%), with a critical difference of 1.36 kPa. The correlation was good to excellent for both the crude overall Pearson coefficient and the ICC, both measuring 0.88 (95% confidence interval, 0.82, 0.92). Subclass ICCs for the fasting state, postprandial state, novice operator, and experienced operator were 0.89, 0.88, 0.90, and 0.86, respectively. The 2-way mixed effect analysis of variance showed that the volunteers accounted for 86.3% of variation in median liver stiffness, with no statistically significant contribution from operator experience, the prandial state, or the machine (P = .108, .067, and .296, respectively).Conclusions-Our study showed that the 2D SWE techniques had a high degree of reliability and agreement in measurement of liver stiffness in a healthy population. Operator experience and the prandial state did not impart significant variability to stiffness measurements.

show abstract

Differences in liver stiffness values obtained with new ultrasound elastography machines and Fibroscan: A comparative study

Abstract: The present results showed only moderate concordance of the majority of elastography machines with the Fibroscan results, preventing the possibility of the immediate universal adoption of Fibroscan thresholds for defining liver fibrosis staging for all new machines.

Cited by 56 publications

References 18 publications

Liver Stiffness Measurement Allows Early Diagnosis of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome in Adult Patients Who Undergo Hematopoietic Stem Cell Transplantation: Results from a Monocentric Prospective Study

Liver Stiffness Measurement Allows Early Diagnosis of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome in Adult Patients Who Undergo Hematopoietic Stem Cell Transplantation: Results from a Monocentric Prospective Study

Liver elastography malignancy prediction score for noninvasive characterization of focal liver lesions

Reproducibility of 2 Liver 2‐Dimensional Shear Wave Elastographic Techniques in the Fasting and Postprandial States

Contact Info

Product

Resources

About