Differences in levels of oxidative stress in mothers and neonate: the impact of mode of delivery

Abstract

Our findings indicate that those production levels of oxygen free radical in mothers are greater by CD than by VD, while those in neonates are greater by VD than by CD.

Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study

“…IS is formed in the liver from indole, a product of intestinal tryptophan breakdown, and is known to mediate oxidative stress in human umbilical vein endothelial cells . The IS increase in VD cases is consistent with the process involving increased oxidative stress, as reported. , In addition, the decreasing tendency of myo -inositol, found here in common to umbilical cord blood of CS cases compared to VD, may also relate to labor induced stress . The CS group also accommodates a significant increase in the ketone body acetone, which may be indicative of changes in hepatic fatty acids ß-oxidation and gluconeogenesis, consistently with a previous report on CS-born piglets …”

“…Figure (light pink arrows) shows that additional smaller changes are also observed in female newborns, compared to males, in relation to creatinine biosynthesis, methionine cycle and TCA cycle. Differences found in relation to delivery mode are consistent with previous knowledge of (1) lower gut microflora colonization in caesarian section cases, (2) increased stress associated with labor, and (3) possible alterations in hepatic metabolism. − Babies born through CS have reduced bacterial content and delayed appearance of some bacterial species and this may explain the decreased levels of gut-derived metabolites such as PAG and trigonelline found in CS newborn urine (Figure , purple arrows). Another interesting finding regards the significant increase in excreted IS in VD newborns.…”

Postnatale Sauerstoffsättigung reifer Neugeborener

“…Bei der genauenAufschlüsselung des Gestationsalters nach Geburtsmodus fällt auf, dass die primär sektionierten Kinder signifikant früher entbunden werden, im Vergleich zu den Unterschiede mit einer Tendenz zu saureren pH-Werten bei den vaginal (spontan oder vaginal-operativ) entbundenen Kindern(7,26 vs. 7,33). Dies lässt sich möglicherweise durch den vermehrten Geburtsstress der Kinder bei einer Geburt auf dem natürlichen Wege erklären[52]. Als Sauerstoffsättigungsabfall wurde in der hier vorgestellten Analyse bereits ein einzelner Abfall auf einen Wert unter 85% gewertet.…”

<b>Estado oxidativo de neonatos e fêmeas caninas no periparto vaginal eutócico ou cesariana eletiva</b>

“…Simultaneamente ao aumento da criação de cães, as cesarianas eletivas para esta espécie tornaram-se cada vez mais frequentes, visando maximizar a sobrevivência das crias. A cesariana eletiva pode ser indicada para cadelas de raças nas quais há incompatibilidade de diâmetros materno-fetais (principalmente para raças braquicefálicas), cadelas com histórico anterior de distocia ou cesariana prévia, além de cadelas nulíparas com idade igual ou superior a seis anos (RYAN; WAGNER, 2006;SMITH, 2007 (GEORGESON et al, 2002;FOGEL et al, 2005;VAKILIAN et al, 2009;WATANABE et al, 2013 Após a primeira hora de vida, foram avaliadas as variáveis: frequências cardíaca e respiratória, escore de tônus muscular (0-2), escore de irritabilidade reflexa (0-2) e escore de coloração das mucosas (0-2). Ademais, a aferição da temperatura corporal foi realizada em todos os momentos da avaliação clínica neonatal.…”