Differences in internalizing symptoms between those with and without Cannabis Use Disorder among HBCU undergraduate students

Keen, Larry; Turner, Arlener D.; Harris, Toni S.; George, Lauren; Crump, Jonae

doi:10.1080/07448481.2021.1970560

Cited by 2 publications

(1 citation statement)

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“…Legend. *, alternatively, participants used cannabis more than twice a week; age classes, children (< 11 years); adolescents(12)(13)(14)(15)(16)(17)(18); young adults(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30); middle-aged(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50); elderly(51 +); No.+, age classes covered above the age shown by the number; COVID19, study performed during the Covid-19 pandemic; IBD, Inflammatory bowel disease; PTSD, posttraumatic stress disorder; sample size classes, n+, larger than n; <100, smaller than n;…”

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confidence: 99%

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Haller

2024

Preprint

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Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production was mostly uncontrolled, and the idea of medical cannabis was incipient only. We hypothesized that recent changes in attitudes and legislations may have favorably affected research. In addition, publication bias against cannabis may have also decreased. To investigate this hypothesis, we conducted a systematic review of research studies published over the last three years. We found 156 relevant studies. In most cross-sectional studies, depression was higher in those who consumed cannabis than in those who did not. An increase in cannabis consumption was typically followed by an increase in depression, whereas withdrawal from cannabis ameliorated depression in most cases. Albeit medical cannabis reduced depression in most studies, none of these were placebo controlled. In clinical studies published in the same period, placebo also ameliorated depression and in addition, the average effect size of placebo was larger than the average effect size of medical cannabis. We also investigated the plausibility of the antidepressant effects of cannabis by reviewing molecular and pharmacological studies. Taken together, the reviewed findings do not support the antidepressant effects of herbal cannabis.

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confidence: 99%

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Haller

2024

Preprint

View full text Add to dashboard Cite

show abstract

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Haller

2024

Pharmaceuticals

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Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production was mostly uncontrolled, and the idea of medical cannabis was incipient only. We hypothesized that recent changes in attitudes and legislations may have favorably affected research. In addition, publication bias against cannabis may have also decreased. To investigate this hypothesis, we conducted a review of research studies published over the last three years. We found 156 relevant research articles. In most cross-sectional studies, depression was higher in those who consumed cannabis than in those who did not. An increase in cannabis consumption was typically followed by an increase in depression, whereas withdrawal from cannabis ameliorated depression in most cases. Although medical cannabis reduced depression in most studies, none of these were placebo-controlled. In clinical studies published in the same period, the placebo also ameliorated depression and, in addition, the average effect size of the placebo was larger than the average effect size of medical cannabis. We also investigated the plausibility of the antidepressant effects of cannabis by reviewing molecular and pharmacological studies. Taken together, the reviewed findings do not support the antidepressant effects of herbal cannabis.

show abstract

Differences in internalizing symptoms between those with and without Cannabis Use Disorder among HBCU undergraduate students

Cited by 2 publications

References 51 publications

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

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