Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19

Kusumastuti, Etty Hary; Wiratama, Priangga Adi; Ariani, Grace; Djuanda, Stephanie Natasha; Rahniayu, Alphania; Kurniasari, Nila; Fauziah, Dyah; Rahaju, Anny Setijo; Marhana, Isnin Anang; Rosyid, Alfian Nur; Wahyu, Dwi; Nugroho, Gilang Muhammad Setyo; Anggoro, Adhitri; Yandi, I Komang Rusgi; Semedi, Bambang Pujo; Lilihata, Jilientasia Godrace; Maimunah, Ummi; Supriadi, Supriadi; Lefi, Achmad Lefi Achmad; Rinjani, Lalu Galih Pratama; Suyanto, Edi; Nugraha, Ricardo Adrian

doi:10.5530/pj.2022.14.184

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interleukin-6 (IL-6) is a hallmark cytokine of fatal COVID-19 and plays a role in the pathogenesis of COVID-19 [ 9 , 17 - 19 ]. Approximately 80% of patients with severely to critically ill COVID-19 have been reported to experience cytokine storms related to a rise in IL-6 [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19

Maimunah,

Maharani,

Soegiarto

et al. 2023

Narra J

View full text Add to dashboard Cite

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19

Maimunah,

Maharani,

Soegiarto

et al. 2023

Narra J

View full text Add to dashboard Cite

show abstract

Interleukin-6 and Interleukin-10 as a Predictor of Mortality in Elderly with COVID-19

Rosyid,

Puspitasari,

Sensusiati

et al. 2024

Annals of African Medicine

View full text Add to dashboard Cite

Context: The age group at the most high risk for mortality due to SARS-CoV-2 infection was the elderly Aims: This study aims to analyze markers that can predict the severity and mortality of elderly COVID-19 patients Settings and Design: This study used a cohort retrospective design. We include adult and elderly COVID-19 patients at Universitas Airlangga Hospital from March to August 2021 Subjects and Methods: The sample used was 48 COVID-19 patients with positive real-time polymerase chain reaction swab results. We check the complete blood count and serum levels of interleukin-6 (IL-6) and IL-10 using enzyme-linked immunosorbent assay during admission Statistical Analysis Used: Data were analyzed using t-test, Mann–Whitney, Chi-square, Pearson, and Kendall Tau correlation Results: Leukocyte level (6.6 ± 2.5) was lowest in the severe–critical elderly group. Neutrophil level (75.3 ± 10.2) was highest in the mild–moderate elderly group. Lymphocyte level (18.8 ± 8.7) was highest in mild–moderate nonelderly group. Platelet level (279.0 ± 117.7) was highest in the mild–moderate elderly group. Neutrophil to lymphocyte ratio level (9.1 ± 9.4) was highest in the severe–critical nonelderly group, IL-6 level (98.6 ± 144.1) was highest in the severe–critical elderly group, IL-10 level (107.7 ± 47.7) was highest in the severe–critical elderly group and highest IL-6/IL-10 level (1.4 ± 1.7) was found in the mild–moderate elderly group no significant differences in biomarkers identification between the elderly and nonelderly groups. There was a substantial relationship between IL-10 levels and gender, IL-10 level, and hospital discharge condition Conclusions: Female elderly patients and alive elderly patients were correlated with increased levels of IL-10.

show abstract

Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19

Cited by 2 publications

References 27 publications

Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19

Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19

Interleukin-6 and Interleukin-10 as a Predictor of Mortality in Elderly with COVID-19

Contact Info

Product

Resources

About