Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

Tulic, Meri K.; Hodder, Megan; Forsberg, Anna; McCarthy, Suzi; Richman, Tara R.; D’Vaz, Nina; Biggelaar, Anita H. J. van den; Thornton, Catherine A.; Prescott, Susan L.

doi:10.1016/j.jaci.2010.09.020

Cited by 145 publications

(166 citation statements)

References 22 publications

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“…La presencia de algunos factores ambientales, o la falta de exposición a otros, influencian la función inmune modificando el "priming" inmunológico. 135 Los aspectos relevantes se detallan en la Tabla 12.…”

Section: Prevenciónunclassified

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

Alergia¹

2018

Arch Argent Pediatr

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Section: Prevenciónunclassified

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

Alergia¹

2018

Arch Argent Pediatr

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“…This could also be due to the fact that there were few allergic children included in these analyses, although we did detect higher levels of TLR2 mRNA expression in non-allergic than allergic infants at 12 months of age. Other studies suggest differences in TLR responsiveness between children who do or do not develop allergy [85][86][87].…”

Section: Lactobacillus Reuteri and Toll-like Receptorsmentioning

confidence: 99%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

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“…The neonatal immune system seems immature since many cell types have poor responses in the neonates, especially to pathogenic microorganisms, as evident in both human and murine studies [202][203][204]. Also, there seem to be differences between infants later developing allergies and non-allergic infants [205,206]. Initially, it was demonstrated that murine neonates were indeed competent to develop immune responses, but these responses were skewed to the Th2 lineage [202].…”

Section: Prenatal Development Of the Immune Systemmentioning

confidence: 99%

“…Allergic infants have been shown to have exaggerated responses to TLR stimuli [205,206]. In addition, it has also been shown that infants that later develop allergic diseases have an increased Th2 deviation already before clinical symptoms of disease [90,213,214].…”

Section: Immune Development In Relation To Allergymentioning

confidence: 99%

“…Other studies suggest differences in TLR responsiveness between children who do and do not develop allergy [205,206,246]. While TLR ligand stimulation resulted in exaggerated responses at birth in children later developing allergy [206], these responses later seem to be attenuated in allergic compared to non-allergic children at the age of five years [205,246].…”

Section: Allergic and Non-allergic Infant Response To Tlr Ligand Stimmentioning

confidence: 99%

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Immunomodulatory effects of probiotic supplementation during pregnancy and infancy in allergy prevention studies

Forsberg¹

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Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

Cited by 145 publications

References 22 publications

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Immunomodulatory effects of probiotic supplementation during pregnancy and infancy in allergy prevention studies

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