Differences in injection rates on contrast-enhanced breath-hold three-dimensional MR angiography.

Kopka, L.; Vosshenrich, R.; Rodenwaldt, J.; Grabbe, E.

doi:10.2214/ajr.170.2.9456943

Cited by 96 publications

(46 citation statements)

References 16 publications

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“…Other studies which addressed the increase of the injection rate did not demonstrate any significant improvement of peak vascular enhancement [27]. In a further study [28], a fast injection rate of 6 ml/s using a single dose led to a lack of coverage, increased image blurring and nonuniform vascular enhancement. It was concluded that the optimal injection rate for examination of the abdominal aorta and its branches was 2 ml/s.…”

Section: Discussionmentioning

confidence: 81%

Dose optimization of contrast-enhanced carotid MR angiography

Unterweger

Froehlich

et al. 2005

Eur Radiol

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The purpose of this work was to compare the diagnostic performance of a single-contrast or a double-contrast dose of carotid contrast-enhanced MR angiography (MRA). One-hundred nineteen patients (mean age 65+/-14.4 years) underwent carotid contrast-enhanced MRA with a standardized protocol (repetition time/echo 3.73 ms/1.38 ms, flip-angle 25 degrees, acquisition-time 19 s, voxel size 1.2 x 1.2 x 0.9 mm3) on a 1.5-T scanner (Sonata, Siemens-Medical-Systems) using a neck phased-array coil. Contrast agent was administered intravenously at a rate of 3.0 ml/s, either as a single dose (n=57; 0.1 mmol/kg body weight) or as a double dose (n=62; 0.2 mmol/kg body weight) of meglumine gadoterate (0.5 M/l), followed by 30 ml saline. Qualitative image analysis was performed on maximum intensity projections using a five-point scale. Signal intensities were measured at three different vascular levels on both sides to assess the contrast-to-noise ratios (CNRs). Image quality was rated as good or excellent in all cases. A double dose did not influence the efficacy of carotid enhancement (CNR single dose 69.12+/-19.8; CNR double dose 70.01+/-20.7; p = 0.81) compared with a single dose. In both dose groups the mean CNRs were inversely related to bodyweight, despite adjusted contrast volumes (p=0.0005). Double-dose contrast-enhanced carotid MRA is not superior to single-dose MRA, as overall diagnostic performance and quantitative contrast enhancement are equal. Being more cost-efficient, a single-dose administration of contrast agent is recommended for MRA of the carotid arteries.

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Section: Discussionmentioning

confidence: 81%

Dose optimization of contrast-enhanced carotid MR angiography

Unterweger

Froehlich

et al. 2005

Eur Radiol

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“…9 On the other hand, higher contrast doses are known to improve the peak signal-to-noise ratio. 22 Although it may be assumed that a higher contrast agent dose and faster injection should enable the best hemodynamic analysis, Kopka et al 23 reported that flow rates higher than 4 mL/s may lead to reduced image contrast due to problems with typically applied k-space sampling techniques during image acquisition. The main idea of the k-space sampling technique is to sample the center of the k-space, which mainly contributes to the image contrast, more often than the peripheral segments.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Influence of 4D MR Angiography Temporal Resolution on Time-to-Peak Estimation Error for Different Cerebral Vessel Structures

Forkert

Illies

Möller

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Time-resolved MRA imaging is a promising technique for blood flow evaluation in case of cerebrovascular malformations. Unfortunately, 4D MRA imaging is a trade-off between spatial and temporal resolution. The aim of this study was to investigate the influence of temporal resolution on the error associated with TTP estimation from indicator dilution curves derived from different vascular structures.

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“…This technique would decrease the dilution of the contrast bolus by unenhanced blood from conjoining branches and consequently increase the gadolinium concentration in the right atrium. As a test dose of contrast, we injected 2 ml to accentuate the venous enhancement, although 1 ml was suggested for the arterial time±intensity curve [9,12,13]. The injection rate of contrast media was set to 3 ml/s with the intention of a higher injection rate, although, according to our knowledge, there has been no report suggesting an optimal injection rate for the 3D turbo-FLASH sequence.…”

Section: Discussionmentioning

confidence: 99%

“…Total dose varies from the standard (0.1 mmol/kg) to 60 ml [4,8,9,10,11]. The optimal injection rate of contrast media for three-dimensional fast imaging with steady procession (FISP) has been reported as 2 ml/s [12]. Digital subtraction angiography and maximum intensity projection (MIP) techniques are also popular postprocessing methods [1,13].…”

mentioning

confidence: 99%

Optimizing of gadolinium-enhanced MR angiography by manipulation of acquisition and scan delay times

et al. 2001

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An optimized protocol for achieving high-quality contrast-enhanced MR angiography (CE MRA) was designed and evaluated. Time-intensity curves of the test bolus and main bolus were compared in 11 volunteers. To identify the acquisition zone sensitive to venous overprojection, sequential filling phantoms which consisted of 12 test tubes were developed and scanned. Using the parameters of the time-intensity curve which were consistent between the test and main boluses and the parameters of the sensitive acquisition zone in the pulse sequences, the protocol for calculation of scan delay time and acquisition time was optimized. The new protocol was verified by comparison of lower extremity CE MRAs acquired by traditional (scan delay time = peak enhancement time minus injection duration/2 + acquisition time/2; n = 12) and new (n = 23) protocols. The arterial and venous enhancing times of the time-intensity curves of the test and main boluses were statistically consistent (p < 0.01). The length of the sensitive acquisition zone was one-half the acquisition duration. With the parameters identified in the time-intensity curve and pulse sequence analyses, a new protocol was developed. For validation, the new protocol was able to study the smaller arteries such as the distal tibial arteries and branches of the femoral and iliac arteries (p < 0.01). Using the optimized protocol, higher-quality images were obtained than those acquired by traditional methods.

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Differences in injection rates on contrast-enhanced breath-hold three-dimensional MR angiography.

Cited by 96 publications

References 16 publications

Dose optimization of contrast-enhanced carotid MR angiography

Dose optimization of contrast-enhanced carotid MR angiography

Analysis of the Influence of 4D MR Angiography Temporal Resolution on Time-to-Peak Estimation Error for Different Cerebral Vessel Structures

Optimizing of gadolinium-enhanced MR angiography by manipulation of acquisition and scan delay times

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