Differences in Incidence, Mortality and Survival of Breast Cancer by Regions and Countries in Asia and Contributing Factors

Kim, Yeon-Ju; Yoo, Keun-Young; Goodman, Marc T.

doi:10.7314/apjcp.2015.16.7.2857

Cited by 81 publications

(107 citation statements)

References 145 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, this decrease in mortality rate has not flowed through to many developing countries suggesting both curative and preventive intervention, such as community level screening, are central to reducing breast cancer mortality. In many south-east Asian countries, no comprehensive population screening programs exist and later diagnosis of breast cancer is the result (Kim et al, 2015), and this is perhaps the most probable cause for the higher mortality rate observed in resource-limited settings. Instead, in resource-limited countries like Thailand, mammography tends to be limited to diagnosis (Virani et al, 2014) and breast self-examination remains one of the most common ways the disease is detected in the resource-limited setting.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Breast Cancer Awareness in Thai Women

Hurst

Promthet

Rakkapao

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Breast cancer is the most common cancer in women worldwide. In south-east Asia, both the incidence and mortality rates of breast cancer are on the rise, and the latter is likely due to the limited access to large-scale community screening program in these resource-limited countries. Breast cancer awareness is an important tool which may, through increasing breast self-examination and the seeking of clinical examination, reduce breast cancer mortality. Investigating factors associated with breast cancer awareness of women is likely to help identify those at risk, and provide insights into developing effective health promotion interventions. Objective: To investigate factors associated with breast cancer awareness in Thai women. Methods: A cross-sectional sample of Thai women aged 20-64 years was collected during August to October, 2015 from two provinces of southern Thailand (Surat Thani and Songkla). A questionnaire including the Breast Cancer Awareness Scale along with demographic characteristics was administered and Proportional Odds Logistic regression was then used to investigate factors associated with breast cancer awareness. Results: In total, 660 Thai women participated in this study. Factors most often associated with the various breast cancer awareness domains were age and rurality. While rural women had poorer knowledge of breast cancer signs and symptoms, they also had lower levels of perceived barriers and considerably better breast cancer awareness behaviors. Conclusion: Despite lower knowledge of breast cancer risk factors and no evidence of better knowledge of signs and symptoms, we found rural Thai women had considerably better breast cancer awareness behavior. This may be due to these women's lower levels of perceived barriers to breast cancer screening services. Indeed this suggests, at least in Thai women, that interventions aimed at lowering perceived barriers rather than enhancing disease knowledge may be more successful in engaging women with breast cancer screening services and increasing breast self-examination.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Associated with Breast Cancer Awareness in Thai Women

Hurst

Promthet

Rakkapao

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…In breast cancer patients, studies have shown that high levels of MET expression are associated with favorable prognosis [92,93], have no significant association [94,95], or report statistically significant association between MET overexpression and poor prognosis [68]. The differences in the characteristics of breast cancer between Asian and Western populations have been discussed in various reports [100][101][102]. Results of subgroup analysis according to ethnicity has suggested that MET is a predictor of poor prognosis (both RFS and OS) in Western patients but not in the Asian patients [70].…”

Section: Ii-a-2-breast Cancermentioning

confidence: 99%

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Moosavi

Giovannetti

Saso³

et al. 2019

Critical Reviews in Clinical Laboratory Sciences

124

View full text Add to dashboard Cite

Cancer is a major cause of death worldwide. MET tyrosine kinase receptor [MET, c-MET, hepatocyte growth factor (HGF) receptor] pathway activation is associated with the appearance of several hallmarks of cancer. The HGF/MET pathway has emerged as an important actionable target across many solid tumors; therefore, biomarker discovery becomes essential in order to guide clinical intervention and patient stratification with the aim of moving towards personalized medicine. The focus of this review is on how the aberrant activation of the HGF/MET pathway in tumor tissue or the circulation can provide diagnostic and prognostic biomarkers and predictive biomarkers of drug response. Many meta-analyses have shown that aberrant activation of the MET pathway in tumor tissue, including MET gene overexpression, gene amplification, exon 14 skipping and other activating mutations, is almost invariably associated with shorter survival and poor prognosis. Most meta-analyses have been performed in non-small cell lung cancer (NSCLC), breast, head and neck cancers as well as colorectal, gastric, pancreatic and other gastrointestinal cancers. Furthermore, several studies have shown the predictive value of MET biomarkers in the identification of patients who gain the most benefit from HGF/MET targeted therapies administered as single or combination therapies. The highest predictive values have been observed for response to foretinib and savolitinib in renal cancer, as well as tivantinib in NSCLC and colorectal cancer. However, some studies, especially those based on MET expression, have failed to show much value in these stratifications. This may be rooted in lack of standardization of methodologies, in particular in scoring systems applied in immunohistochemistry determinations or absence of oncogenic addiction of cancer cells to the MET pathway, despite detection of overexpression. Measurements of amplification and mutation aberrations are less likely to suffer from these pitfalls. Increased levels of MET soluble ectodomain (sMET) in circulation have also been associated with poor prognosis; however, the evidence is not as strong as it is with tissue-based biomarkers. As a diagnostic biomarker, sMET has shown its value in distinguishing cancer patients from healthy individuals in prostate and bladder cancers and in melanoma. On the other hand, increased circulating HGF has also been presented as a valuable prognostic and diagnostic biomarker in many cancers; however, there is controversy on the predictive value of HGF as a biomarker. Other biomarkers such as circulating tumor DNA (ctDNA) and tumor HGF levels have also been briefly covered. In conclusion, HGF/MET aberrations can provide valuable diagnostic, prognostic and predictive biomarkers and represent vital assets for personalized cancer therapy.

show abstract

“…Researchers believe that employee women generally have higher income and are more likely to use health insurance and spend the most on healthcare [37]. However, it seems that the association of job status with risk of breast cancer remains unknown or controversial [38,39]. This needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Investigation Risk Factors for Breast Cancer in Women: A Case–Control Study in Arak, Iran

Pezeshki

Ansari

Rezaie

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundBreast cancer is the most common malignant in women globally. In Iran, breast cancer incidence rate is continuously increasing. This study aimed to investigate the risk factors for breast cancer in Iranian women.MethodsA hospital-based case-control study was conducted between September 2016 and July 2019 in Arak, Iran. The sample size was 400 breast cancer patients and 400 healthy women. Demographical records and risk factor related data were collected. Logistic regression analysis used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsData showed that among various factors, urban life (OR = 1.361, 95% CI 1.025–1.808, P = 0.033), height (OR = 3.347, 95% CI 2.0443–5.480, P = 0.000), BMI (OR = 0.397, 95% CI 0.273–0.577, P = 0.000), education level (OR = 7.048, 95% CI 3.985–12.467, P = 0.000), awareness level (OR = 0.507, 95% CI 0.349–0.736, P = 0.000), job status (OR = 0.321, 95% CI 0.122–0.846, P = 0.022), economic status (OR = 4.333, 95% CI 1.424–13.184, P = 0.010), early menarche (OR = 2.815, 95% CI 1.745–4.541, P = 0.000), Stillbirth status (OR = 1.935, 95% CI 1.087–3.446, P = 0.025), family history (OR = 10.281, 95% CI 3.628–29.134, P = 0.000), behavioral habits (OR = 0.554, 95% CI 0.386–0.796, P = 0.001), and second-hand smoking (OR = 1.472, 95% CI 1.108–1.955, P = 0.008) significantly were associated with an increased risk for breast cancer.ConclusionThe data suggest that lifestyle may have more impact on the incidence of breast cancer in Iranian women, suggesting change unhealthy lifestyle and screening for preventing breast cancer.

show abstract

Differences in Incidence, Mortality and Survival of Breast Cancer by Regions and Countries in Asia and Contributing Factors

Cited by 81 publications

References 145 publications

Factors Associated with Breast Cancer Awareness in Thai Women

Factors Associated with Breast Cancer Awareness in Thai Women

HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers

Investigation Risk Factors for Breast Cancer in Women: A Case–Control Study in Arak, Iran

Contact Info

Product

Resources

About