Differences in hyperpolarized <sup>3</sup>He ventilation imaging after 4 years in adults with cystic fibrosis

Paulin, Gregory; Svenningsen, Sarah; Jobse, Brian N.; Mohan, Sindu; Kirby, Miranda; Lewis, James F.; Párraga, Grace

doi:10.1002/jmri.24744

Cited by 22 publications

(23 citation statements)

References 23 publications

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“…There will be a growing role for HP gas MRI in assessing therapy response and disease progression in CF [133, 269–271] and pediatric lung diseases in general as this technology, and MRI as a whole, are actively extended to study childhood [256, 261, 272] and neonatal [272, 273] lung diseases.…”

Section: Applications Of Hyperpolarized Gas Mri To Pre-clinical Anmentioning

confidence: 99%

Magnetic resonance imaging with hyperpolarized agents: methods and applications

et al. 2017

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In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (3He) and xenon (129Xe) gases have reached the stage where they are under study in clinical research. HP 129Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of 129Xe gas exchange into lung tissue and blood, HP 129Xe MRI is attracting new attention. In parallel, HP 13C and 15N MRI methods have steadily advanced in a wide range of pre-clinical research applications for imaging metabolism in various cancers and cardiac disease. The HP [1-13C] pyruvate MRI technique, in particular, has undergone phase I trials in prostate cancer and is poised for investigational new drug trials at multiple institutions in cancer and cardiac applications. This review treats the methodology behind both HP gases and HP 13C and 15N liquid state agents. Gas and liquid phase HP agents share similar technologies for achieving non-equilibrium polarization outside the field of the MRI scanner, strategies for image data acquisition, and translational challenges in moving from pre-clinical to clinical research. To cover the wide array of methods and applications, this review is organized by numerical section into 1) a brief introduction, 2) the physical and biological properties of the most common polarized agents with a brief summary of applications and methods of polarization, 3) methods for image acquisition and reconstruction specific to improving data acquisition efficiency for HP MRI, 4) the main physical properties that enable unique measures of physiology or metabolic pathways, followed by a more detailed review of the literature describing the use of HP agents to study 5) metabolic pathways in cancer and cardiac disease and 6) lung function in both pre-clinical and clinical research studies, 7) some future directions and challenges, and 8) an overall summary.

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Section: Applications Of Hyperpolarized Gas Mri To Pre-clinical Anmentioning

confidence: 99%

Magnetic resonance imaging with hyperpolarized agents: methods and applications

et al. 2017

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“…Following this, hyperpolarized helium-3 MRI (HP 3 He MRI) has been examined in multiple settings and has shown high sensitivity for the detection of ventilation impairments [34][35][36][37][38][39][40][41][42][43][44]. This typically requires production of hyperpolarized gas on site which is then mixed with nitrogen and administered to patients with a one litre Tedlar Bag.…”

Section: Hyperpolarized Helium-3 Mrimentioning

confidence: 99%

Evaluation of high resolution computed tomography findings of cystic fibrosis

Şaşihüseyinoğlu

Altıntaş

Soyupak

et al. 2019

Korean J Intern Med

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Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current 'gold standard' method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis. X-ray phase-contrast imaging is another emerging X-ray based methodology for Cystic Fibrosis lung assessment which provides dynamic morphological and functional information, albeit with even higher X-ray doses than HRCT. Magnetic Resonance Imaging (MRI) is a non-ionising radiation imaging method that is garnering growing interest among researchers and clinicians working with Cystic Fibrosis patients. Recent advances in MRI have opened up the possibilities to observe lung function in real time to potentially allow sensitive and accurate assessment of disease progression. The use of hyperpolarized gas or non-contrast enhanced MRI can be tailored to clinical needs. While MRI offers significant promise it still suffers from poor spatial resolution and the development of an objective scoring system especially for ventilation assessment.

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“…In humans, stunning 3-D data sets of the lung with resolution of a few millimeters can now be acquired in a ten-second breath-hold (Qing et al , 2015). A variety of diseases have been studied, among them cystic fibrosis (Flors et al , 2016; Mentore et al , 2005; Paulin et al , 2015) (see Fig. 22), asthma (Kruger et al , 2014; Tustison et al , 2010), and emphysema (Kirby et al , 2013; Quirk et al , 2011; Spector et al , 2005).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Optically polarizedHe3

et al. 2017

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This article reviews the physics and technology of producing large quantities of highly spin-polarized 3He nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) optical pumping. Both technical developments and deeper understanding of the physical processes involved have led to substantial improvements in the capabilities of both methods. For SEOP, the use of spectrally narrowed lasers and K-Rb mixtures has substantially increased the achievable polarization and polarizing rate. For MEOP nearly lossless compression allows for rapid production of polarized 3He and operation in high magnetic fields has likewise significantly increased the pressure at which this method can be performed, and revealed new phenomena. Both methods have benefitted from development of storage methods that allow for spin-relaxation times of hundreds of hours, and specialized precision methods for polarimetry. SEOP and MEOP are now widely applied for spin-polarized targets, neutron spin filters, magnetic resonance imaging, and precision measurements.

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Differences in hyperpolarized ³He ventilation imaging after 4 years in adults with cystic fibrosis

Cited by 22 publications

References 23 publications

Magnetic resonance imaging with hyperpolarized agents: methods and applications

Magnetic resonance imaging with hyperpolarized agents: methods and applications

Evaluation of high resolution computed tomography findings of cystic fibrosis

Optically polarizedHe3

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Differences in hyperpolarized 3He ventilation imaging after 4 years in adults with cystic fibrosis

Cited by 22 publications

References 23 publications

Magnetic resonance imaging with hyperpolarized agents: methods and applications

Magnetic resonance imaging with hyperpolarized agents: methods and applications

Evaluation of high resolution computed tomography findings of cystic fibrosis

Optically polarizedHe3

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Product

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Differences in hyperpolarized ³He ventilation imaging after 4 years in adults with cystic fibrosis