Differences in hormonal characteristics of conceptive versus nonconceptive menstrual cycles

Li, Hongxia; Nakajima, Steven T.; Chen, Jiangang; Todd, Heather; Overstreet, James W.; Lasley, Bill L.

doi:10.1016/s0015-0282(00)01765-9

Cited by 29 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These EIAs are thus likely to be useful for monitoring reproductive function in a broad range of applications, including those in which women may have very low hormone concentrations. The E1C assay performs similarly to, and cross-reacts with the same metabolites as, the widely used R522 polyclonal antibody assay (1,5,15,(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research

O’Connor

Brindle²,

Holman³

et al. 2003

Clinical Chemistry

Self Cite

102

View full text Add to dashboard Cite

Background:Monitoring of reproductive steroid hormones at the population level requires frequent measurements, hormones or metabolites that remain stable under less than ideal collection and storage conditions, a long-term supply of antibodies, and assays useful for a range of populations. We developed enzyme immunoassays for urinary pregnanediol 3-glucuronide (PDG) and estrone conjugates (E1Cs) that meet these criteria. Methods: Enzyme immunoassays based on monoclonal antibodies were evaluated for specificity, detection limit, parallelism, recovery, and imprecision. Paired urine and serum specimens were analyzed throughout menstrual cycles of 30 US women. Assay application in different populations was examined with 23 US and 42 Bangladeshi specimens. Metabolite stability in urine was evaluated for 0 -8 days at room temperature and for 0 -10 freeze-thaw cycles. Results: Recoveries were 108% for the PDG assay and 105% for the E1C assay. Serially diluted specimens exhibited parallelism with calibration curves in both assays. Inter-and intraassay CVs were <11%. Urinary and serum concentrations were highly correlated: r ‫؍‬ 0.93 for E1C-estradiol; r ‫؍‬ 0.98 for PDG-progesterone.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The widely used R522 E1C EIA (1,5,15,(17)(18)(19) also uses a polyclonal antibody in a similar format. Our first objective was to evaluate the performance of urinary PDG and E1C EIAs using monoclonal antibodies.…”

mentioning

confidence: 99%

Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research

O’Connor

Brindle²,

Holman³

et al. 2003

Clinical Chemistry

Self Cite

102

View full text Add to dashboard Cite

show abstract

“…Based on a large body of research with humans, Ellison argues that women experience a continuum of ovarian function (or dysfunction) that is associated with varying levels of energetic stress [Ellison, 2003;Ellison et al, 1993b]. Women experiencing moderate levels of energetic stress may still have regular menstrual cycles but produce lower levels of the reproductive hormones estradiol and progesterone, leading to lower likelihoods of ovulation, fertilization, or implantation [Eissa et al, 1986;Li et al, 2001;Lipson & Ellison, 1996]. This model is supported by substantial empirical evidence for higher ovarian function in women from relatively well-nourished populations, and within populations, in women who are in positive energy balance and maintaining a low physical workload [Ellison et al, 1989[Ellison et al, , 1993aJasienska & Ellison, 1998;Panter-Brick et al, 1993].…”

Section: Reproductive Energeticsmentioning

confidence: 99%

Reproductive Ecology of Female Chimpanzees

Thompson

2012

American J Primatol

103

View full text Add to dashboard Cite

An important adaptive problem for mammals in general, and primates in particular, is how females can manage the high costs of reproduction in the face of fluctuating energetic supplies. For many species, the best solution is to breed seasonally such that high costs are temporally coincident with predictable periods of resource abundance. This is an unreliable strategy for some primates, such as chimpanzees (Pan troglodytes), for which large body size forces an increase in dietary complexity and prolonged reproductive efforts. Here, I review data on reproductive function in chimpanzees, a species that demonstrates a risk-averse reproductive strategy wherein reproductive investment is allocated in accordance with maternal condition. Life history parameters for chimpanzees indicate that most females produce very few surviving offspring. However, comparisons between captive and wild populations and within wild populations illustrate that variation in resource access leads to highly variable reproductive success. Focused hormonal studies have demonstrated these effects at a proximate level, with energetic influences on female dispersal, receptivity, cycle quality, conception success, and lactational amenorrhea. Downstream of these effects, female reproductive function affects sexual attractiveness, and by virtue of males' own optimal reproductive strategies, can lead to coercive aggression and decreased foraging efficiency. Because of their extreme reproductive costs, female chimpanzees utilize a highly conservative reproductive strategy, one that minimizes the costs of ecological variation but makes them vulnerable to sexual conflict and costs of sociality.

show abstract

“…Diminished FSH secretion during this time appears to delay the recruitment of the next follicle cohort, with a consequent delay of ovulation in the next menstrual cycle and a prolongation of its follicular phase. Although the delay of ovulation does not appear to decrease fecundity as indicated by the periovulatory hormone profiles (Li et al 2001), one important adverse effect is a transient resorption of bone. Such perturbations, if repetitive, may increase the risk of osteoporosis in later life.…”

Section: Shorter Cycles Longer Cyclesmentioning

confidence: 99%

Bone resorption is affected by follicular phase length in female rotating shift workers.

Lohstroh

Chen

et al. 2003

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

Stressors as subtle as night work or shift work can lead to irregular menstrual cycles, and changes in reproductive hormone profiles can adversely affect bone health. This study was conducted to determine if stresses associated with the disruption of regular work schedule can induce alterations in ovarian function which, in turn, are associated with transient bone resorption. Urine samples from 12 rotating shift workers from a textile mill in Anqing, China, were collected in 1996-1998 during pairs of sequential menstrual cycles, of which one was longer than the other (28.4 vs. 37.4 days). Longer cycles were characterized by a prolonged follicular phase. Work schedules during the luteal-follicular phase transition (LFPT) preceding each of the two cycles were evaluated. All but one of the shorter cycles were associated with regular, forward phase work shift progression during the preceding LFPT. In contrast, five longer cycles were preceded by a work shift interrupted either by an irregular shift or a number of "off days." Urinary follicle-stimulating hormone levels were reduced in the LFPT preceding longer cycles compared with those in the LFPT preceding shorter cycles. There was greater bone resorption in the follicular phase of longer cycles than in that of shorter cycles, as measured by urinary deoxypyridinoline. These data confirm reports that changes in work shift can lead to irregularity in menstrual cycle length. In addition, these data indicate that there may be an association between accelerated bone resorption in menstrual cycles and changes of regularity in work schedule during the preceding LFPT.

show abstract

Differences in hormonal characteristics of conceptive versus nonconceptive menstrual cycles

Cited by 29 publications

References 12 publications

Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research

Urinary Estrone Conjugate and Pregnanediol 3-Glucuronide Enzyme Immunoassays for Population Research

Reproductive Ecology of Female Chimpanzees

Bone resorption is affected by follicular phase length in female rotating shift workers.

Contact Info

Product

Resources

About