Differences in HIV RNA levels before the initiation of antiretroviral therapy among 1864 individuals with known HIV-1 seroconversion dates

Touloumi, Giota; Pantazis, Nikos; Babiker, Abdel; Walker, Sarah; Κατσαρού, Όλγα; Karafoulidou, Anastasia; Hatzakis, Angelos; Porter, Kholoud

doi:10.1097/01.aids.0000131395.14339.f5

Cited by 59 publications

(51 citation statements)

References 43 publications

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“…If R value is small, then it takes large errors. For R square 0.701, nearly one third the variation in viral load is explained by the independent variable cd4 cell count similar to other studies [5][6][7][8]. The viral load is inversely proportional to CD4 cell count [9,10].…”

Section: Discussionsupporting

confidence: 81%

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Study of Viral Load and CD4 Count in Diagnosis of HIV-1 Positive Patients

Kumar¹

2017

J Fam Med

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This study reports the distribution of CD4 counts and viral loads in first-time HIV positive patients.One hundred cases of different kinds of HIV/AIDS were included in this study. Written consent was obtained from each participant for their information to be stored in the clinic database and used for research purposes. Blood samples were collected from these volunteers in the sterilized vials and processed for CD4 count and viral load.Data were analyzed with statistical package (SPSS 16.0) software and correlation coefficients and correlation matrix were determined.One hundred cases (37 males and 63 females) of different kinds of HIV/ AIDS were included in this study with a mean age ranged from 33.45 ± 13.052. Half of the patients below 29 years of age and only 4% are above 59 years of age. Relationship between the CD4 cell count and the dependent variable viral load. R, the multiple correlation coefficients, is the linear correlation between the observed and predicted values of the dependent variable viral load. Its large value indicates a strong relationship between CD4 cell count values and viral load (R=0.837). If R value is small, then it takes large errors. For R square 0.701, nearly one third the variation in viral load is explained by the independent variable CD4 cell count. The Gender wise mean comparison of viral load in CD4 positive patients was found significant (p<0.05).HIV-infected men at their first HIV diagnosis are more likely to have lower CD4 counts and higher viral loads than women.

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Section: Discussionsupporting

confidence: 81%

“…Other studies have noted gender differences in viral loads and CD4 at various stages of the disease, where females develop AIDS at higher CD4 counts and lower viral loads [6][7][8].…”

Section: Discussionmentioning

confidence: 92%

Study of Viral Load and CD4 Count in Diagnosis of HIV-1 Positive Patients

Kumar¹

2017

J Fam Med

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“…Higher HIV RNA in men has been previously reported in other settings. 32 Concerning the percentage analysis, the association of male gender and low CD4 persisted in adjusted analysis.…”

Section: Meanings and Implicationsmentioning

confidence: 95%

Comparison of Early CD4 T-Cell Count in HIV-1 Seroconverters in Côte d'Ivoire and France: The ANRS PRIMO-CI and SEROCO Cohorts

Lewden¹,

Thiébaut²,

Boufassa³

et al. 2010

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…13,14 Individuals who seroconvert at an older age appear to have higher HIV RNA concentrations. 15 Age-related changes in pharmacokinetics have not been well studied in this population.…”

Section: Introductionmentioning

confidence: 96%

Age-Related Changes in Plasma Concentrations of the HIV Protease Inhibitor Lopinavir

Crawford

Spritzler

Kalayjian

et al. 2010

AIDS Research and Human Retroviruses

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The advent of highly active antiretroviral therapy in the treatment of HIV disease has substantially extended the lifespan of individuals infected with HIV resulting in a growing population of older HIV-infected individuals. The efficacy and safety of antiretroviral agents in the population are important concerns. There have been relatively few studies assessing antiretroviral pharmacokinetics in older patients. Thirty-seven subjects aged 18-30 years and 40 subjects aged 45-79 years, naive to antiretroviral therapy, received lopinavir=ritonavir (400=100) bid, emtricitibine 200 mg qd, and stavudine 40 mg bid. Trough lopinavir concentrations were available for 44 subjects, collected at 24, 36, and 96 weeks. At week 24, older age was associated with higher lopinavir trough concentrations, and a trend was observed toward older age being associated with higher lopinavir trough concentrations when all time points were evaluated. In the young cohort, among subjects with two or more measurements, there was a trend toward increasing intrasubject trough lopinavir concentrations over time. Using a nonlinear, mixed-effects population pharmacokinetic model, age was negatively associated with lopinavir clearance after adjusting for adherence. Adherence was assessed by patient self-reports; older patients missed fewer doses than younger patients ( p ¼ 0.02). No difference in grade 3-4 toxicities was observed between the two age group. Older patients have higher trough lopinavir concentrations and likely decreased lopinavir clearance.

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Differences in HIV RNA levels before the initiation of antiretroviral therapy among 1864 individuals with known HIV-1 seroconversion dates

Cited by 59 publications

References 43 publications

Study of Viral Load and CD4 Count in Diagnosis of HIV-1 Positive Patients

Study of Viral Load and CD4 Count in Diagnosis of HIV-1 Positive Patients

Comparison of Early CD4 T-Cell Count in HIV-1 Seroconverters in Côte d'Ivoire and France: The ANRS PRIMO-CI and SEROCO Cohorts

Age-Related Changes in Plasma Concentrations of the HIV Protease Inhibitor Lopinavir

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