Differences in Hematological Characteristics, Including Cholesterol and Apolipoprotein B and E, between Hepatitis B Virus and Hepatitis C Virus Patients in Korea

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) chronically cause hepatitis, liver cirrhosis, and hepatocellular carcinoma, and biomarkers related to liver damage are elevated in HBV and HCV patients. However, comparisons of biomarkers between HBV and HCV patients have not previously been reported. The aim of this study was to investigate differences in hematological biomarker in the sera of HBV and HCV patients and to find a key biomarker to differentiate between HBV and HCV infections. HBV (n=115) and HCV (n=128) samples (serum and whole blood) were collected and tested using a biochemical analysis system. The obtained data were analyzed with SPSS 18.0 statistical software. The mean age of the HCV group (60.3±14.1) was much higher than that of the HBV group (51.1±12.4). Male and female rates were 71.3% and 28.7% in the HBV group and 53.9% and 46.1% in the HCV group, respectively (p = 0.005). AST, ALT, and TG values were higher in the HCV group than in the HBV group. Although γ-GTP and LDL levels were higher in the HBV group than in the HCV group, apoB and apoE levels were much higher in HCV group than in HBV group (p < 0.001). There were no significant differences in the other hematological biomarkers between the HBV and HCV groups.In conclusion, HBV rates were higher in male patients, and HCV rates were higher in older patients. In particular, apoE and apoB were more highly expressed in HCV patients, and they might be key markers to differentiate HCV infection.

A Correlative Study Between Haematological and Biochemical Parameters in Hepatitis B

“…Also very high increment in both ALT and/or GGT obtained in this study can provide a valuable information through the assessment of hepatic inflammation and fibrosis and beside Plt no other biochemical tests have been shown to be a better indicators of liver injury. Another important mediator of host immune defence CRP and Alb showed level increment in sera of HBV individuals compared with controls at (P≤0.05) , our finding is in agreement with other studies [16,30], these findings sound not unusual since liver is the target, organ for the replication of HBV , leading to the demolition of hepatocytes and, consequently increase the releasing of these molecules [18]. The effect of HBV infection on liver's clearance of pancreatic enzymes was followed by evaluation of Amy activity, Table 1, revealed significant increase(p≤0.05) in Amy activity in HBV patients compared with control group, our results are in agreement with Katakura Yet al [36], and Kaur N et al [19].…”

“…The marked increase of acutephase CRP occurs with inflammations, viral infections and tissue necrosis [16]. Nemours studies have performed on the relationship of CRP with the severity of inflammation in liver diseases, such HBV [13], [16][17][18]. An increase of pancreatic enzymes is generally an expression of inflammatory disease or pancreatic cancer.…”

Apolipoprotein E Genotype and Expression Correlated with Hepatitis C Virus Genotype and Infection

“…HCV infection is associated with a decrease in serum levels of total cholesterol, LDL cholesterol (18). In previous study, we already confirmed that HCV infection are strongly associated with low levels of main cholesterol biomarker (HDL, LDL, and total cholesterol) (12). We reconfirmed it through this study.…”