Differences in gut microbiota profile between women with active lifestyle and sedentary women

Bressa, Carlo; Bailén-Andrino, María; Pérez-Santiago, Jennifer; González-Soltero, Rocío; Pérez, Margarita; Montalvo-Lominchar, Maria Gregoria; Maté-Muñoz, José Luis; Domínguez, Raúl; Moreno, Diego A.; Larrosa, Mar

doi:10.1371/journal.pone.0171352

Cited by 371 publications

(429 citation statements)

References 73 publications

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“…These women had a body fat/muscular mass percentage, significantly correlating with several gut microbial communities [97]. The authors suggested that those findings were supportive of a pattern of exercise inclined to break sedentary behaviours while beneficially modifying gut microbiota.…”

Section: Human Studiesmentioning

confidence: 89%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

128

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Please cite this article as: Codella Roberto, Luzi Livio, Terruzzi Ileana.Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases.Digestive and Liver Disease https://doi.org/10.1016/j.dld. 2017.11.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractLimited animal and human research findings implied that exercise might have a

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Section: Human Studiesmentioning

confidence: 89%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

128

View full text Add to dashboard Cite

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“…These two families contain bacteria associated with butyrate-production and are found in low-abundance in sedentary women, hypertensive Dahl salt-sensitive rats, and HFD mice fecal microbiota. 30 , 139 , 140 …”

Section: Discussionmentioning

confidence: 99%

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

et al. 2018

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Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We then completed a gut microbiota and cardiometabolic profile of the adult female offspring. Results: The metabolic assessment revealed that adult PNA rats had increased body weight and increased mRNA expression of adipokines: adipocyte binding protein 2, adiponectin, and leptin in inguinal white adipose tissue. Radiotelemetry analysis revealed hypertension with decreased heart rate in PNA animals. The fecal microbiota profile of PNA animals contained higher relative abundance of bacteria associated with steroid hormone synthesis, Nocardiaceae and Clostridiaceae, and lower abundance of Akkermansia, Bacteroides, Lactobacillus, Clostridium. The PNA animals also had an increased relative abundance of bacteria associated with biosynthesis and elongation of unsaturated short chain fatty acids (SCFAs). Conclusions: We found that prenatal exposure to excess androgen negatively impacted cardiovascular function by increasing systolic and diastolic blood pressure and decreasing heart rate. Prenatal androgen was also associated with gut microbial dysbiosis and altered abundance of bacteria involved in metabolite production of short chain fatty acids. These results suggest that early-life exposure to hyperandrogenemia in daughters of women with PCOS may lead to long-term alterations in gut microbiota and cardiometabolic function.

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“…Apart from host genetics, a number of endogenous and exogenous factors shape microbial communities in the gut. These include dietary and alcohol intake, smoking, sex and hormonal cycles, diurnal variation, physical activity, and xenobiotic exposure (including antibiotics) …”

Section: Factors That Shape the Gut Microbiomementioning

confidence: 99%

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease

et al. 2018

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The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism of environmental, dietary, and host‐derived substrates, which produce bioactive metabolites. Perturbations to the composition and associated metabolic output of the gut microbiome have been associated with a number of chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). Here, we review the rapidly evolving suite of next‐generation techniques used for studying gut microbiome composition, functional gene content, and bioactive products and discuss relationships with the pathogenesis of NAFLD.

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Differences in gut microbiota profile between women with active lifestyle and sedentary women

Cited by 371 publications

References 73 publications

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease

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