Differences in Glucose Determinations Obtained from Plasma or Whole Blood

McDonald, Glen W.; Fisher, Gail F.; Burnham, C. E.

doi:10.2307/4592174

Cited by 26 publications

(7 citation statements)

References 1 publication

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“…(9.6 per cent) for the nondiabetics. Thus, as found by other workers, 6 there is a proportional difference between the glucose concentrations of blood and plasma. d.…”

Section: Comparison Of Blood and Plasmasupporting

confidence: 59%

Critical Analysis of Blood Sugar Measurements in Diabetes Detection and Diagnosis

et al. 1967

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An analysis of 702 blood sugar levels during glucose tolerance tests shows that the site of blood sampling influences the blood sugar result. Capillary blood taken from the warm ear lobe gives an accurate reflection of the arterial blood sugar level. Compared to the arterial level the venous blood sugar level is unpredictable and differs from the arterial to a varying extent, e.g., from +26 mg. per 100 ml. to -4 mg. per 100 ml. at two hours in the glucose tolerance test depending on many factors.Studies of the macromethod in the AutoAnalyzer indicate that although the reproducibility is good, the volume of blood pumped by the proportioning pump is inaccurate (too small). Analysis of the micromethod shows that the reproducibility is also good, though not quite so good as the macromethod. However, the sample volume taken for analysis by the proportioning pump is accurate.Reasons are given for recommending that capillary, not venous, blood be taken, and that the ferricyanide-reducing micromethod on the AutoAnalyzer be used for blood glucose estimation. DIABETES 16: 219-26, April, 1967. This paper is concerned with the accuracy of blood sugar estimations and the variations between the arterial, capillary and venous blood sugar levels in various types of subjects. DEFINITIONS Subjects Nondiabetics: Arterial blood sugar less than 140 mg. per 100 mL two hours after 50 gm. glucose by mouth.Borderline diabetics: Arterial blood sugar 140 to 200 mg. per 100 ml. two hours after 50 gm. glucose.Diabetics: Arterial blood sugar greater than 200 mg. per 100 mL two hours after 50 gm. glucose. Measurement of obesitySkinfold thickness measured (in ' triplicate) with skinfold calipers in the midtriceps region for women,

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“…(9.6 per cent) for the nondiabetics. Thus, as found by other workers, 6 there is a proportional difference between the glucose concentrations of blood and plasma. d.…”

Section: Comparison Of Blood and Plasmasupporting

confidence: 59%

Critical Analysis of Blood Sugar Measurements in Diabetes Detection and Diagnosis

et al. 1967

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“…As a result, whole blood sugar concentration will lie somewhere between those of erythrocyte and plasma and will be affected inversely by changes in hematocrit. 1 ' 2 It is the purpose of this report to illustrate how anemia can raise the blood sugar from normal to pathological concentrations and to provide a means by which plasma sugar levels, if determined, may be converted to those of whole blood sugar for evaluation by whole blood standards.…”

mentioning

confidence: 99%

Importance of the Hematocrit in Interpretation of Blood Sugar

Dillon

1965

Diabetes

103

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“…In addition to interpretation of results, glucose tolerance testing involves problems of sampling (capillary vs. venous, 21 serum or plasma vs. whole blood 22 ), delays in separation of red cells, concentration of anti-coagulant, and analytical methodology. A Cooperative Glucose Standardization Program is available from the Center for Disease Control in Atlanta to assist laboratories in selfstandardization.…”

Section: Criteria For Interpretation Of the Oral Glucose Testmentioning

confidence: 99%

Chemical Diabetes Mellitus in Childhood: Report of a Conference

1972

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The recognition of chemical diabetes mellitus in children has led to questions of diagnostic criteria, methodology of testing, choice of populations to study and possible therapeutic approaches to the prevention of progression to overt (insulin-dependent) diabetes. Since the natural history of chemical diabetes in children includes spontaneous improvement as well as stability or progression of glucose intolerance, evaluation of the significance of abnormality and the effect of potential therapy is difficult. The oral glucose tolerance test (OGTT), despite problems in interpretation and methodology, remains the only generally accepted test for chemical diabetes in children. Criteria for interpretation of the OGTT in children used by pediatric investigators are similar to the Fajans and Conn standards for adults. Application of these criteria to certain high risk groups, including obese children, children with mild symptoms suggestive of hypoglycemia, and siblings of those with overt diabetes, has permitted the identification of 200 children with this stage of diabetes. Approximately 11 per cent have progressed to insulin dependency during one to seventeen years of observation. Data on treatment of these patients is limited to anecdotal reports or summaries of small groups of patients treated for variable periods with sulfonylurea drugs. It is not possible to recommend a therapeutic program for children with chemical diabetes, except in the case of the overweight child, where diet restriction may be as efficacious as in adults. Thus, testing of high risk persons and attempts at treatment should only be undertaken in an investigational setting. DIABETES 2i: 45-49, January, 1972. The conference was organized to exchange information on the identification and management of chemical diabetes in children in an attempt to establish recommendations for diagnostic criteria, methodology, populations to study and therapeutic investigation. Thirtytwo papers were presented and will be published as proceedings. 1 The following is a synthesis and summary of each of the four conference sessions.

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Differences in Glucose Determinations Obtained from Plasma or Whole Blood

Abstract: Glucose determinations obtained on the AutoAn¬ alyzer from plasma are consistently higher than those obtained from whole blood. These

Cited by 26 publications

References 1 publication

Critical Analysis of Blood Sugar Measurements in Diabetes Detection and Diagnosis

Critical Analysis of Blood Sugar Measurements in Diabetes Detection and Diagnosis

Importance of the Hematocrit in Interpretation of Blood Sugar

Chemical Diabetes Mellitus in Childhood: Report of a Conference

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