Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y

Sudakov, S. K.; Medvedeva, O. F.; Rusakova, I. V.; Nn, Terebilina; Goldberg, Steven R.

doi:10.1007/s002130000651

Cited by 25 publications

(9 citation statements)

References 34 publications

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“…NPY, one of the most abundant peptide transmitters in the mammalian brain, is synthesized in response to stress and plays an important role in regulating some behavioural parameters (Leibowitz, 1991; Morgan et al ., 2002). This neurotransmitter is present in high concentrations in the amygdala and hippocampus (Parker & Herzog, 1999), the NPY system appears to modulate anxiety and emotionality (Heilig & Widerlov, 1995) and anxiety in rats can be reduced by intracerebroventricular administration of NPY (Sudakov et al ., 2001).…”

Section: Discussionmentioning

confidence: 99%

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation

Fiore

Amendola

Triaca

et al. 2003

Eur J of Neuroscience

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The condition of dominance or submission following agonistic encounters in the adult male mouse is known to differentially affect brain nerve growth factor, a neurotrophin playing a role in brain remodeling, in the fine tuning of behaviour and in the regulation of the basal forebrain cholinergic neurons. During development and adult life nerve growth factor regulates brain expression of neurotransmitters and the stimulation of progenitor cells (stem cells) which, under different external stimuli, may differentiate into neuronal and/or glial cells promoting the recovery of the injured brain. However, little information is available for the aged brain. Thus in the present study we investigated the effect of the social status ('dominance' vs. 'submission') in the aged mouse on the presence of nerve growth factor, brain-derived neurotrophic factor, choline acetyltransferase, neuropeptide Y and progenitor cells of selected brain regions. We found that aged dominant mice showed increased brain-derived neurotrophic factor in the subventricular zone and hippocampus and increased choline acetyltransferase in the septum and basal nuclei, which were associated with increased presence of progenitor cells in the subventricular zone. Conversely, in aged subordinate mice the data showed a marked brain increase in nerve growth factor in the subventricular zone and hippocampus, choline acetyltransferase in the septum and basal nuclei and neuropeptide Y in the hippocampus and parietal cortex. The possible functional implications of these findings are discussed.

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Section: Discussionmentioning

confidence: 99%

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation

Fiore

Amendola

Triaca

et al. 2003

Eur J of Neuroscience

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“…Ghrelin has recently been reported to suppress sleep (Szentirmai et al 2006), while central administration of NPY causes sedation, presumably mediated by NPY Y5 receptors (Sorensen et al 2004). In addition, ghrelin and NPY appear to modulate emotional behavior but their effects on anxiety are not conclusive or, in the case of NPY, might depend on particular receptor subtypes and anatomical substrates (Nakajima et al 1998;Asakawa et al 2001;Sudakov et al 2001;Carlini et al 2004;Sorensen et al 2004;Karlsson et al 2005). CRF, an anorexigenic neuropeptide expressed prominently in the paraventricular nucleus of the hypothalamus, is known to have an important role in stress mediation.…”

Section: Comparison With Other Neurotransmitters and Neuropeptidesmentioning

confidence: 96%

Neuropeptide S: A novel modulator of stress and arousal

Okamura

Reinscheid

2007

Stress

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Neuropeptide S (NPS) is a recently identified bioactive peptide that modulates stress and arousal. NPS is expressed in a few discrete nuclei in the brainstem, such as the pericoerulear (locus coeruleus (LC)) area and the parabrachial nucleus. NPS activates its cognate G protein-coupled receptor at low nanomolar agonist concentrations and induces elevation of intracellular Ca2+ and cAMP, therefore acting as an excitatory transmitter. The NPS receptor is widely expressed in the brain, including regions known to regulate stress responses such as hypothalamus, thalamus, amygdala and limbic cortex. We have recently reported that the NPS system can modulate stress responses and induce wakefulness based on a battery of behavioral tests. Activation of NPS receptors induces arousal and reduces all sleep stages. At the same time, NPS produces anxiolytic-like effects in rodents. These studies indicate that the NPS system has a unique pharmacological profile to promote both anxiolytic and arousal effects. NPS might interact with other hypothalamic neuropeptide systems that are known to be involved in stress and appetite control and thus might be a valuable target for development of a new class of drugs to treat anxiety disorders.

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“…In rats, a number of strains displaying spontaneously elevated emotionality as compared with others, thought to model 'trait' anxiety, have been described, including Fischer-344 vs Wistar (e.g. Sudakov et al, 2001), fawn-Hooded vs Wistar or Sprague-Dawley rats (e.g. Kantor et al, 2000;Neophytou et al, 2000) and further examples (reviewed in Ramos and Mormede, 1998).…”

Section: Strains Displaying Spontaneously Elevated Anxietyrelated Behmentioning

confidence: 99%

Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms and functional mapping

Singewald

2007

Neuroscience & Biobehavioral Reviews

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Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y

Abstract: These findings support the hypothesis that decreased levels of SP in certain brain regions may contribute to high levels of anxiety in rats. Decreased levels of DBI and increased levels of NPY in high-anxiety animals may act as compensatory mechanisms.

Cited by 25 publications

References 34 publications

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation

Neuropeptide S: A novel modulator of stress and arousal

Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms and functional mapping

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