Differences in Gastric Mucosal Microbiota Profiling in Patients with Chronic Gastritis, Intestinal Metaplasia, and Gastric Cancer Using Pyrosequencing Methods

Eun, Chang Soo; Kim, Byung Kwon; Han, Dong Soo; Kim, Seon‐Young; Kim, Kyung Mo; Choi, Bo Youl; Song, Kyu Sang; Kim, Yong‐Sung; Kim, Jihyun F.

doi:10.1111/hel.12145

Cited by 233 publications

(240 citation statements)

References 39 publications

Supporting

Mentioning

207

Contrasting

Unclassified

Order By: Relevance

“…The relative abundance of the families Bradyhizobiaceae, Caulobacteraceae, Lactobacillaceae, and Burkholderiaceae was significantly higher in H. pylori-negative patients, whereas the relative abundance of the Helicobacteriaceae family was significantly higher in H. pylori-positive patients (20). …”

Section: H Pylori and Gastric Microbiota In Adultsmentioning

confidence: 84%

“…However, bacteria belonging to the Actinomycetales order were also present and correlated significantly with both conditions (p < 0.01) (25). It is surprising that previous studies on gastric cancer and chronic atrophic gastritis failed to detect these bacteria (20,22,24). The significance of this atypical microbiota colonization remains to be studied.…”

Section: Rev Esp Enferm Digmentioning

confidence: 89%

“…The gastric cancer group showed a significant decrease in the Epsilonproteobacteria class and Helicobacteriaceae family, while the Bacilli class and Streptococacceae family increased significantly (20).…”

Section: Specific Changes In Microbiota Possibly Related To Gastric Cmentioning

confidence: 90%

“…However, Eun et al compared gastric microbiota between patients with gastric cancer, intestinal metaplasia and chronic gastritis and reported that the evenness and diversity of gastric microbiota was significantly increased in gastric cancer (20).…”

Section: Global Gastric Microbiota Diversity and Gastric Cancermentioning

confidence: 99%

“…It is interesting to note that, globally, there is a decrease in bacteria belonging to the phyla Proteobacteria (Neisseria spp [22], Haemophilus spp [22], Bergeriella denitrificans [22], Epsilonproteobacteria [20] and Helicobacteriaceae [20]) and Bacteroidetes (Porphyromonas spp [22] and Prevotella pallens [22]), whereas bacteria belonging to the phyla Firmicutes are either increased (Streptococacceae [20], Lachnospiraceae [22] and Lactobacillus coleohominis [22]) or decreased (Streptococcus sinensis [22]). Klebsiella pneumoniae and Acinetobacter baumannii are two notable exceptions, as they belong to the phylum Proteobacteria, although they tend to increase with gastric carcinogenesis (19).…”

Section: Rev Esp Enferm Digmentioning

confidence: 99%

See 4 more Smart Citations

Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review

et al. 2016

View full text Add to dashboard Cite

Background and aim:Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis.Methods: A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed.Results: Thirteen original articles were included. The constitution of gastric microbiota appears to be significantly affected by gastric cancer and premalignant lesions. In fact, differences in gastric microbiota have been documented, depending on Helicobacter pylori status and gastric conditions, such as non-atrophic gastritis, intestinal metaplasia and cancer. Gastric carcinogenesis can be associated with an increase in many bacteria (such as Lactobacillus coleohominis, Klebsiella pneumoniae or Acinetobacter baumannii) as well as decrease in others (such as Porphyromonas spp, Neisseria spp, Prevotella pallens or Streptococcus sinensis). However, there is no conclusive data that confirms if these changes in microbiota are a cause or consequence of the process of carcinogenesis.Conclusions: Even though there is limited evidence in humans, microbiota differences between normal individuals, premalignant lesions and gastric cancer could suggest a progressive shift in the constitution of gastric microbiota in carcinogenesis, possibly resulting from a complex cross-talk between gastric microbiota and Helicobacter pylori. However, further studies are needed to elucidate the specific role (if any) of different microorganisms.

show abstract

Section: H Pylori and Gastric Microbiota In Adultsmentioning

confidence: 84%

Section: Rev Esp Enferm Digmentioning

confidence: 89%

Section: Specific Changes In Microbiota Possibly Related To Gastric Cmentioning

confidence: 90%

Section: Global Gastric Microbiota Diversity and Gastric Cancermentioning

confidence: 99%

Section: Rev Esp Enferm Digmentioning

confidence: 99%

See 3 more Smart Citations

Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review

et al. 2016

View full text Add to dashboard Cite

show abstract

Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis

et al. 2022

View full text Add to dashboard Cite

Bile reflux gastritis (BRG) is associated with the development of gastric cancer (GC), but the specific mechanism remains elusive. Here, a comprehensive study is conducted to explore the roles of refluxed bile acids (BAs) and microbiome in gastric carcinogenesis. The results show that conjugated BAs, interleukin 6 (IL‐6), lipopolysaccharide (LPS), and the relative abundance of LPS‐producing bacteria are increased significantly in the gastric juice of both BRG and GC patients. A secondary BA, taurodeoxycholic acid (TDCA), is significantly and positively correlated with the LPS‐producing bacteria in the gastric juice of these patients. TDCA promotes the proliferation of normal gastric epithelial cells (GES‐1) through activation of the IL‐6/JAK1/STAT3 pathway. These results are further verified in two mouse models, one by gavage of TDCA, LPS, and LPS‐producing bacteria (Prevotella melaninogenica), respectively, and the other by bile reflux (BR) surgery, mimicking clinical bile refluxing. Moreover, the bile reflux induced gastric precancerous lesions observed in the post BR surgery mice can be prevented by treatment with cryptotanshinone, a plant‐derived STAT3 inhibitor. These results reveal an important underlying mechanism by which bile reflux promotes gastric carcinogenesis and provide an alternative strategy for the prevention of GC associated with BRG.

show abstract

Oral and gastric microbiome in relation to gastric intestinal metaplasia

Yang

Hao

et al. 2021

Intl Journal of Cancer

View full text Add to dashboard Cite

Evidence suggests that Helicobacter pylori plays a role in gastric cancer (GC) initiation.However, epidemiologic studies on the specific role of other bacteria in the development of GC are lacking. We conducted a case-control study of 89 cases with gastric intestinal metaplasia (IM) and 89 matched controls who underwent upper gastrointestinal endoscopy at three sites affiliated with NYU Langone Health. We performed shotgun metagenomic sequencing using oral wash samples from 89 case-control pairs and antral mucosal brushing samples from 55 case-control pairs. We examined the associations of relative abundances of bacterial taxa and functional pathways with IM using conditional logistic regression with and without elastic-net penalty. Compared with controls, oral species Peptostreptococcus stomatis, Johnsonella ignava, Neisseria elongata and Neisseria flavescens were enriched in cases (odds ratios [ORs] = 1.29-1.50, P = .004-.01) while Lactobacillus gasseri, Streptococcus mutans, S parasanguinis and S sanguinis were under-represented (ORs = 0.66-0.76, P = .006-.042) in cases. Species J ignava and Filifactor alocis in the gastric microbiota were enriched (ORs = 3.27 and 1.43, P = .005 and .035, respectively), while S mutans, S parasanguinis and S sanguinis were under-represented (ORs = 0.61-0.75, P = .024-.046), in cases compared with controls. The lipopolysaccharide and ubiquinol biosynthesis pathways were more abundant in IM, while the

show abstract

Differences in Gastric Mucosal Microbiota Profiling in Patients with Chronic Gastritis, Intestinal Metaplasia, and Gastric Cancer Using Pyrosequencing Methods

Cited by 233 publications

References 39 publications

Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review

Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review

Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis

Oral and gastric microbiome in relation to gastric intestinal metaplasia

Contact Info

Product

Resources

About