Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

Foster, Catherine G.; Landowski, Lila M.; Sutherland, Brad A.; Howells, David W.

doi:10.1016/j.physbeh.2021.113347

Cited by 18 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest some long-lasting consequences of LPS treatment, but the effect of endotoxin insult was not as complex as in other studies. While the suppressive effect of LPS on weight gain [24,78,[87][88][89][90][91] and locomotor activity [24,27,88,[92][93][94][95][96][97][98] is well known, the depressive effect of LPS on social exploration of rats described by many authors [24,87,88,92] was not observed in our study.…”

Section: Discussioncontrasting

confidence: 85%

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

Tejkalová

Jakob

Kvasnová

et al. 2022

Preprint

View full text Add to dashboard Cite

The present study investigated whether neonatal exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) followed by antibiotic (ATB)-induced dysbiosis in early adulthood could induce schizophrenia-like behavioral changes in adult male rats. The combination of these two stressors resulted in decreased weight gain, but no significant behavioral abnormalities were observed. LPS treatment resulted in adult rats hypoactivity and induced anxiety-like behavior in the social recognition paradigm, but these behavioral changes were not exacerbated by ATB-induced gut dysbiosis. ATB treatment seriously disrupted the gut bacterial community, but dysbiosis did not affect locomotor activity, social recognition, and acoustic reactivity in adult rats. Fecal bacterial community analyzes showed no differences between the LPS challenge exposed/unexposed rats, while the effect of ATB administration was decisive regardless of prior LPS exposure. ATB treatment resulted in significantly decreased bacterial diversity, suppression of Clostridiales and Bacteroidales, and increases in Lactobacillales, Enterobacteriales, and Burkholderiales. The persistent effect of LPS on some aspects of behavior suggests a long-term effect of early toxin exposure that was not observed in ATB-treated animals. However, an anti-inflammatory protective effect of ATB cannot be assumed because of the increased abundance of pro-inflammatory, potentially pathogenic bacteria (Proteus, Suttrella) and the elimination of the bacterial families Ruminococcaceae and Lachnospiraceae, which are generally considered beneficial for gut health.

show abstract

Section: Discussioncontrasting

confidence: 85%

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

Tejkalová

Jakob

Kvasnová

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…These results suggest some long-lasting consequences of LPS treatment, but the effect of endotoxin insult was less complex than in other studies. While the suppressive effect of LPS on weight gain [ 31 , 90 , [100] , [101] , [102] , [103] , [104] ] and locomotor activity [ 31 , 34 , 101 , [105] , [106] , [107] , [108] , [109] , [110] , [111] ] is well known, the depressive effect of LPS on social exploration of rats described by many authors [ 31 , 100 , 101 , 111 ] was not observed in our study.…”

Section: Discussioncontrasting

confidence: 82%

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

Tejkalová¹,

Jakob²,

Kvasnová³

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Previous report revealed that poly I:C could induce inflammation reaction, while appropriate inflammatory response could play a protective role to defend viral infection [25] , [26] . In this study, we found that two inflammation-related miRNAs (miR-192 and miR-731) were differentially expressed at 24h h after poly I:C treatment.…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of differentially expressed microRNAs in gibel carp Carassius auratus gibelio responding to polyinosinic-polycytidylic acid (poly I:C) stimulation

Zhang

Sun

Mao

et al. 2023

Fish and Shellfish Immunology Reports

View full text Add to dashboard Cite

Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

Cited by 18 publications

References 45 publications

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

Identification and analysis of differentially expressed microRNAs in gibel carp Carassius auratus gibelio responding to polyinosinic-polycytidylic acid (poly I:C) stimulation

Contact Info

Product

Resources

About