Abstract:Ryanodine receptors (RyR) in smooth muscle cells (SMC) underlie Ca2+ sparks and Ca2+‐induced‐Ca2+ release, contributing to the regulation of myogenic tone in arteries. In contrast, RyR are silent and are not involved in Ca2+ signals in SMC or myogenic tone in hamster arterioles. The purpose of the present study was to investigate the role of RyR in vessels of male C57BL/6 mice. We tested the hypothesis that differences in RyR isoform expression contribute to differences in RyR function in iliac feed arteries (… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.