Differences in endoscopic and clinicopathological features of primary and secondary gastric non-Hodgkin's lymphoma

Kolve, M.-E.; Fischbach, Wolfgang; Greiner, Andreas; Wilms, K.

doi:10.1016/s0016-5107(99)70006-4

Cited by 59 publications

(27 citation statements)

References 34 publications

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“…In contrast to secondary gastric NHL, unifocal growth pattern is the most important endoscopic finding in primary gastric NHL. A unifocal growth pattern facilitates local radical treatment strategies, such as surgery, which may be associated with prolonged remission and a more favorable prognosis [10,26] . As the part of diagnostic procedures, we used abdominal CT in concordance to modified Ann Arbor staging system.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to primary gastric NHL, secondary involvement of the GI tract by nodal NHL, which occurs in 20% to 60% of newly diagnosed cases, reflects disseminated disease that necessitates systemic treatment strategies [9,10] . Studies analyzing the incidence of secondary gastric NHL revealed a great discrepancy between the frequencies of GI involvement diagnosed before treatment as opposed to postmortem findings.…”

Section: Introductionmentioning

confidence: 99%

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Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Todorović¹,

Balint²,

Jevtic³

et al. 2008

WJG

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AIM:To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS:Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS:Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%. CONCLUSION:Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Todorović¹,

Balint²,

Jevtic³

et al. 2008

WJG

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“…Isaacson and Wright [24] first introduced the MALT concept, describing the lesion in gastrointestinal tract, thyroid gland, salivary gland, and ovaries. The same year, Warren and Marshall [39] discovered in patients with gastric non-Hodgkin's lymphoma a microorganism which produces urease, named Helicobacter pylori (HP).…”

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confidence: 99%

Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas?

et al. 2003

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“…Clinical symptoms of primary gastric lymphoma are vague and varied, with abdominal pain being the most common complaint, followed by dyspepsia, vomiting and gastric bleeding [48][49][50][51] . Constitutional B symptoms are exceedingly uncommon.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Therapy of gastric mucosa associated lymphoid tissue lymphoma

Morgner

Schmelz²,

Thiede³

et al. 2007

WJG

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Gastric mucosa associated lymphoid tissue (MALT) lymphoma has recently been incorporated into the World Health Organization (WHO) lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been clearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success.

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Differences in endoscopic and clinicopathological features of primary and secondary gastric non-Hodgkin's lymphoma

Cited by 59 publications

References 34 publications

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas?

Therapy of gastric mucosa associated lymphoid tissue lymphoma

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