Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians

Yc, Lou

doi:10.3109/03602539008991447

Cited by 36 publications

(18 citation statements)

References 65 publications

(2 reference statements)

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“…MR = 12.6) is the same in different ethnic groups. Given this limitation, the Oriental populations studied appear to have a very low incidence of the PM trait of metoprolol oxidation as has been observed for debrisoquine hydroxylation in the Japanese and Chinese populations (Eichelbaum & Gross, 1990;Kalow, 1991;Lou, 1990). At present we do not know how many Oriental subjects are required for establishing an exact antimode and frequency of the PMs of the debrisoquine/sparteine-type oxidation polymorphism.…”

Section: Discussionmentioning

confidence: 99%

“…A marked interethnic difference in the incidence of the poor metaboliser (PM) phenotype of debrisoquine, sparteine or metoprolol has been observed (Eichelbaum & Gross, 1990;Kalow, 1991;Lou, 1990). We have recently reported that Japanese and mainland Chinese have a relatively low frequency of the PM phenotype for metoprolol oxidation (Horai et al, 1989) compared with a white British population (Iyun et al, 1986;McGourty et al, 1985), and that the metabolic capacity differs between the extensive metabolisers (EMs) of the two Oriental populations (Horai et al, 1989 .…”

Section: Introduction Methodsmentioning

confidence: 99%

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Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.

Sohn¹,

Shin²,

Cw³

et al. 1991

Brit J Clinical Pharma

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We examined metoprolol oxidation capacity in 218 unrelated, healthy Korean subjects using the 8 h urinary metabolic ratio (MR) of metoprolol to ot-hydroxymetoprolol after an oral dose of 100 mg metoprolol tartrate. The results were compared with those from 295 Japanese and 107 mainland Chinese whose metoprolol oxidation capacities were assessed in a similar manner. The frequency of occurrence of poor metabolisers (PMs) was 0.5% (1/218) in the Korean, 0.7% (2/295) in the Japanese and 0% in the Chinese population. However, the respective mean (± s.d.) MRs (0.84 ± 1.14 and 0.87 ± 0.90) in the Korean and Japanese extensive metabolisers (EMs) were significantly (P < 0.001) less than that in the Chinese EMs (2.81 ± 2.35), and the mode of the distribution histogram and the probit plot of data for Chinese EMs were shifted to the right compared with those for Korean and Japanese EMs. The results indicate that Koreans, like Japanese and mainland Chinese, have a much lower frequency of the PM phenotype of debrisoquine/ sparteine-type oxidation compared with that reported for Caucasian populations. Chinese EMs appear to have a lower capacity to metabolise metoprolol to a-hydroxymetoprolol compared with Korean or Japanese EMs.

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Section: Discussionmentioning

confidence: 99%

Section: Introduction Methodsmentioning

confidence: 99%

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.

Sohn¹,

Shin²,

Cw³

et al. 1991

Brit J Clinical Pharma

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“…Genetic factors a¡ecting enzyme activities are frequently important determinants in the disposition of drugs, including exogenous and endogenous hormone as well as their e⁄cacy and toxicity [May, 1994]. Racial patterns based on the gene polymorphism of the cytochrome P450 enzyme have been proposed as the causes of some observed di¡erences in estrogen metabolism between premenopausal Asian women and Caucasian women [Lou, 1990].…”

Section: Discussionmentioning

confidence: 99%

Relationship between urinary profile of the endogenous steroids and postmenopausal women with stress urinary incontinence

Bai

Jung

Chung

et al. 2003

Neurourology and Urodynamics

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Twenty post-partum women with clinically diagnosed stress urinary incontinence and 20 age-matched postmenopausal women without stress urinary incontinence (control group) were evaluated. We compared urinary profile of the endogenous steroid hormones patients with stress urinary incontinence and controls, and between grade I and grade II of stress urinary incontinence. We also investigated the relationship between urinary profile of the endogenous steroid hormones and prognostic parameters of stress urinary incontinence (maximal urethral closure pressure, functional urethral length, Valsalva leak point pressure, cough leak point pressure, posterior urethrovesical angle, bladder neck descent, and stress urethral axis). The ages of the patients and those in the control group were 64.3 +/- 5.6 and 57.5 +/- 3.8 years old and the body mass indexes were 24.96 +/- 3.14 and 22.11 +/- 2.73 kg/m2 in patients and in normal subjects, respectively. Nine patients were grade I and 11 were grade II. Estrone and 17beta-estradiol only were detected in all subjects, regardless of control or patient group. It is noteworthy that there were no significant differences (P > 0.05) in the levels of estrone and 17beta-estradiol in the urine of postmenopausal normal subjects compared with in the urine of postmenopausal patients with urinary incontinence. E2/E1 ratio was not different between the two groups (P > 0.05). Among the objective steroids, DHEA, Delta4-dione, Delta5-diol, Te, DHT, 16alpha-DHT, 11-keto An, THDOC, and THB were not detected either in the urine of normal subjects and nor in the urine of the patients. After comparing androgen levels between normal subjects and patients, no significant differences (P>0.05) were detected, except for 5alpha-THB and 5alpha-THF. Neither 5alpha-THB or 5alpha-THF were detected in the patients' urine. Et/An (11beta-OH Et/11beta-OH An) concentration ratios were not significantly different between the two groups, either (P > 0.05). There were not significant differences of concentrations (micromol/g creatinine) of urinary steroids between grade I and grade II of stress urinary incontinence. Pregnanediol was significantly related to bladder neck descent in supine and sitting positions (R = 0.79, P = 0.01, and R = 0.73, P = 0.03, respectively), and pregnanetriol was significantly related to maximal urethral closure pressure and functional urethral length (R = 0.68, P = 0.04, and R = -0.79, P = 0.01, respectively). Androsterone was significantly related to bladder neck descent in supine and sitting positions (R = 0.68, P = 0.04, and R = 0.78, P = 0.01, respectively). 5-AT was significantly related to bladder neck descent in sitting position and stress urethral axis (R = 0.72, P = 0.03, and R = -0.71, P = 0.03). 11-keto Et was significantly related to bladder neck descent in supine and sitting positions and related to stress urethral axis (R = 0.82, P = 0.01, and R = 0.81, P = 0.01, R = -0.67, P = 0.04, respectively). THS was significantly related to bladder neck descent in supine and sitting positions...

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“…[1][2][3][4] Some authors have studied the possible pharmacokinetic differences of drugs commonly used in ethnic groups from different places in the world. [5][6][7][8][9] Mexico has great variety of ethnic groups, approximately 63 different cultures are located in the center, southwest and north of the country, site where flourished great cultures. The Otomies, which inhabit in the Valle del Mezquital and in the State of Mexico in the center of the Mexican Republic, are one of the most important ethnic groups of Mexico.…”

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confidence: 99%

Pharmacokinetics and Metabolic Rates of Acetyl Salicylic Acid and Its Metabolites in an Otomi Ethnic Group of Mexico

Lares‐Asseff

Juárez-Olguı́n

Flores‐Pérez

et al. 2004

Biological & Pharmaceutical Bulletin

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Differences in Drug Metabolism Polymorphism Between Orientals and Caucasians

Cited by 36 publications

References 65 publications

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations.

Relationship between urinary profile of the endogenous steroids and postmenopausal women with stress urinary incontinence

Pharmacokinetics and Metabolic Rates of Acetyl Salicylic Acid and Its Metabolites in an Otomi Ethnic Group of Mexico

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