Differences in determinants affecting longitudinal change of brachial-ankle pulse wave velocity due to differences in baseline among Japanese male workers

Abstract

No study has examined whether the determinants of longitudinal changes in brachial-ankle pulse wave velocity differ depending on the baseline brachial-ankle pulse wave velocity values. Therefore, this study aimed to extract these determinants in high-and low-value groups based on the FY2014 brachial-ankle pulse wave velocity values. [Participants and Methods] Participants were 97 male workers who underwent continuous health assessments from FY2014 to four years later. Their demographic, lifestyle, body-composition, and hemodynamic data were recorded. First-year data were subtracted from data obtained four years later for each continuous variable item, and the difference divided by the number of years was considered as the annual change. Based on the first-year median brachial-ankle pulse wave velocity, participants were classified into high-and low-brachialankle pulse wave velocity groups, i.e., high-and low-value groups, respectively. Multiple regression analysis was performed with the annual change in brachial-ankle pulse wave velocity serving as the dependent variable for both groups.[Results] In comparison with the values obtained in the first year, brachial-ankle pulse wave velocity obtained four years later increased significantly in the low-value group and tended to increase in the high-value group. Increased visceral fat area in the high-value group and increased diastolic blood pressure and heart rate in the lowvalue group were associated with worsening brachial-ankle pulse wave velocity. [Conclusion] The determinants of longitudinal changes in the brachial-ankle pulse wave velocity differed depending on the baseline brachial-ankle pulse wave velocity values.

Bidirectional association between SBP variability and arterial stiffness in patients with chronic kidney disease: findings from KNOW-CKD study

“…Arterial stiffness has been regarded as an independent risk factor for the development of CVD, and it is well recognized that the stiffening of arteries increases with age and is accelerated by cardiovascular risk factors [33][34][35][36]. Among various contributing factors for arterial stiffening, BP is the most important component [34,37]. Conventionally, studies showing the association between BP and arterial stiffness have used a single BP value as a predictor of arterial stiffness [7,37,38].…”

“…Among various contributing factors for arterial stiffening, BP is the most important component [34,37]. Conventionally, studies showing the association between BP and arterial stiffness have used a single BP value as a predictor of arterial stiffness [7,37,38]. Recently, timeupdated BP or BP variability has been used to account for changes in BP during follow-up, because BP is not constant and varies from visit to visit [39][40][41].…”