Differences in coronary plaque composition with aging measured by coronary computed tomography angiography

Tota-Maharaj, Rajesh; Blaha, Michael J.; Rivera, Juan J.; Henry, Travis S.; Choi, Eue Keun; Chang, S.; Yoon, Yeonyee E.; Chun, Eun Ju; Choi, Sang Il; Blumenthal, Roger S.; Chang, Hyuk Jae; Nasir, Khurram

doi:10.1016/j.ijcard.2011.01.041

Cited by 24 publications

(19 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taylor et al (2005) reported altered CAC scores in 22.4% of men and 7.9% of women in the Prospective Army Coronary Calcium Project (PACC), which analyzed 2000 participants with a mean age of 43 years. Tota-Maharaj et al (2012) reported a prevalence of high CAC scores in 5% of their study subgroup, which had a mean age of 40 years. Considering that our study population had a lower mean age than that of other studies (36.3 years) and we still found a higher prevalence of abnormal CAC scores than that found in studies of nonobese subjects, we can assume that severe obesity is an important contributor to vascular calcification.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Altered coronary artery calcium scores before bariatric surgery

et al. 2014

View full text Add to dashboard Cite

IntroductionObesity is an important cause of cardiovascular disease, especially coronary artery disease. Severely obese patients are particularly prone to this risk. The coronary artery calcium (CAC) score is a strong predictor of coronary heart disease and provides incremental information beyond traditional risk factors. We sought to determine the prevalence of abnormally high CAC scores in the preoperative setting among patients undergoing bariatric surgery and to establish risk predictors for higher scores.MethodsWe performed an observational study of 202 patients free of known coronary artery disease who were referred for bariatric surgery. In each patient, the presence of CAC was detected with computed tomography, and coronary risk variables were either measured or determined via questionnaire.ResultsCAC was found in 14.4% of the overall population (26% of male and 10.5% of female patients). Participants with altered CAC scores were older (mean age, 46.8 years). The variables positively associated with an altered CAC score were older age, male sex, type 2 diabetes, hypertension, and hypercholesterolemia. Multivariate-adjusted analysis showed that age (OR, 1.11; 95% CI, 1.06–1.17; p = 0.001), male sex (OR, 4.17; 95% CI, 1.52–11.47; p = 0.006), and hypercholesterolemia (OR, 6.21; 95% CI, 1.81–21.29; p = 0.004) were most closely related to the presence of CAC.ConclusionObese patients in the preoperative bariatric surgery setting have a high prevalence of abnormal CAC scores. Traditional risk factors play a important role in this scenario.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Previous studies have reported that older age is a main risk factor of higher CAC scores (Tota-Maharaj et al 2012; McClelland et al 2006; Budoff et al 2007). McClelland et al (2006) reported that the relationship between the probability of any detectable calcium and age is linear.…”

Section: Discussionmentioning

confidence: 98%

Altered coronary artery calcium scores before bariatric surgery

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Our data suggest that these markers of subclinical atherosclerosis (BrachD and CAC) may have different pathophysiologic pathways and measurement of each may provide complementary information on early atherosclerosis. Most young people, even with T1D, don't have measurable CAC (20, 21, 22). The BrachD may therefore be telling us additional information about the younger populations cardiovascular complications through a separate pathway.…”

Section: Discussionmentioning

confidence: 99%

Reduced brachial artery distensibility in patients with type 1 diabetes

Ljunggren

Maahs

Johansson

et al. 2016

Journal of Diabetes and its Complications

View full text Add to dashboard Cite

Background and aims In patients with type 1 diabetes mellitus (T1D), cardiovascular disease (CVD) events are more common and occur earlier in life than in non-diabetics. Reduced brachial artery distensibility (BrachD) is an independent risk factor for development of CVD. Our aim was to determine if adults with T1D have lower BrachD compared to adults without diabetes and also to determine how age and gender affect the relationship of BrachD with T1D status. Materials and methods BrachD was measured using the Dynapulse instrument in 829 participants (352 with T1D, 477 non-diabetics). An ANCOVA model was used to test the association of BrachD with age, sex, and T1D, and the significance of an age*sex*T1D interaction. Results Mean BrachD was lower in T1D patients vs. controls (6.43±1.46 vs. 7.16±1.48 % change per mmHg, p<0.0001). In a model adjusted for age, T1D, and sex, the interaction of age*T1D*sex was significant (p=0.0045). Younger women both with and without T1D had higher BrachD than men with and without T1D, but older women with and without T1D had lower BrachD compared to older men with and without T1D. Women with T1D had a steeper decline in BrachD with age than nondiabetic women. Conclusions BrachD is lower in T1D patients than in non-diabetics, indicating increased vascular stiffness. Younger females have higher BrachD than males, but the decline with age in BrachD is steeper for women, particularly among those with T1D. BrachD may be an inexpensive, non-invasive method to ascertain increased CVD risk in this population.

show abstract

“…5, overestimation of stenosis length may result from turbulent flow downstream from the stenosis. Non-invasive plaque imaging and characterization is an exciting topic, with emerging data from MRA and CTA [32][33][34]. b. Multi-slab versus whole-heart coronary MRA To obtain diagnostic image quality it is necessary to maintain a regular heart rhythm during sampling intervals.…”

Section: Discussionmentioning

confidence: 99%