Differences in Clinical Characteristics between Patients with Endoscopy-Negative Reflux Disease and Erosive Esophagitis in Japan

Fujiwara, Yasuhiro; Higuchi, Kazuhide; Shiba, Masatsugu; Yamamori, Kazuki; Watanabe, Yozo; Sasaki, Eiji; Tominaga, Kazunari; Watanabe, Toshio; Oshitani, Nobuhide; Arakawa, Tetsuo

doi:10.1111/j.1572-0241.2005.40966.x

Cited by 85 publications

(94 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Smoking was inversely related to NERD compared with RE [22] . Smoking decreases lower esophageal sphincter pressure and increases the frequency of reflux episodes.…”

Section: ) Patientsmentioning

confidence: 97%

“…The previous studies showed that male gender is a risk factor for erosive esophagitis; whereas female is more likely to be associated with NERD [21,22] . Less parietal cell mass in women may be underlining reasons for the lower risk of GE [23] .…”

Section: ) Patientsmentioning

confidence: 99%

“…Smoking decreases lower esophageal sphincter pressure and increases the frequency of reflux episodes. In addition, deleterious effects on esophageal defenses such as reduction of esophageal clearance and salivary function have been described [22] .…”

Section: ) Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Juan¹,

Du²,

Jiang³

et al. 2007

WJG

View full text Add to dashboard Cite

AIM:To analyze the spectrum and risk factors of gastroesophageal reflux disease (GERD) based on presenting symptoms and endoscopic findings. METHODS:A cross-sectional survey in a cluster random sample was conducted from November 2004 to June 2005 using a validated Chinese version Reflux Disease Questionnaire (RDQ) and other items recording the demographic characteristics and potential risk factors for GERD. Subjects were defined as having GERD symptoms according to the RDQ score (> 12). All subjects were endoscopied and the definition and severity of erosive esophagitis were evaluated by Los Angeles classification. The statistical analysis was performed with SPSS13.0 programs. RESULTS:Of 2231 recruited participants, 701 (31.40%) patients were diagnosed as having GERD while 464 (20.80%) patients had objective findings of reflux esophagitis (RE). Of those 464 patients, only 291 (13.00%) were reported as subjects with GERD symptoms. A total of 528 (23.70%) patients were found to have GERD symptoms, including 19.50% patients with grade A or B reflux esophagitis, 0.90% with grade C and 0.40% with grade D. On multivariate analysis, old age, male, moderate working burden, divorced/widowed and strong tea drinking remained as significant independent risk factors for erosive esophagitis. Meanwhile, routine usage of greasy food and constipation were considered as significant independent risk factors for non-erosive reflux disease (NERD). CONCLUSION:GERD is one of the common GI diseases with a high occurrence rate in China and its main associated factors include sex, anthropometrical variables and sociopsychological characteristics.

show abstract

“…Smoking was inversely related to NERD compared with RE [22] . Smoking decreases lower esophageal sphincter pressure and increases the frequency of reflux episodes.…”

Section: ) Patientsmentioning

confidence: 97%

Section: ) Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Juan¹,

Du²,

Jiang³

et al. 2007

WJG

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, this is the first prospective population-based study to explore an association between chronic HBV infection and GERD. The increased incidence of GERD in HBV carriers was independent of other known risk factors [16][17][18]. Moreover, we found a differential association between genders and APRI levels, and chronic HBV infection was an independent risk factor of erosive esophagitis, especially in female subjects and Data are shown by mean ± standard deviation or proportion of the character P \ 0.05 is considered as statistical significance those with higher APRI levels.…”

Section: Discussionmentioning

confidence: 75%

Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection

et al. 2010

View full text Add to dashboard Cite

Background Although chronic liver disease is associated with gastroesophageal reflux disease (GERD), the impact of chronic hepatitis B virus (HBV) infection on this association remains unclear. We thus aimed to evaluate the relationship between chronic HBV infection and GERD.Methods In this prospective population-based study, 1,001 adult subjects who underwent an upper gastrointestinal endoscopic examination in a health check-up and completed a gastroesophageal reflux questionnaire were consecutively enrolled. Endoscopic findings were classified according to the Los Angeles classification. Hepatitis B surface antigen was used as a marker of HBV infection. Univariate and multivariate approaches were used to evaluate the effects of chronic HBV infection on GERD.Results Chronic HBV infection was associated with heartburn sensation [odds ratio (OR) 1.27, 95% confidence interval 1.01-1.61, P = 0.037], and erosive esophagitis (adjusted OR 1.75, 1.03-2.97, P = 0.037). Although male gender is a risk factor of erosive esophagitis, further analyses stratified by gender and aspartate aminotransferase to platelet ratio index (APRI) showed that chronic HBV infection was associated with erosive esophagitis in female subjects (adjusted OR 2.70, 1.14-6.39, P = 0.024) and those with APRI of more than 0.3 (adjusted OR 3.94, 1.73-8.96, P = 0.001). Moreover, higher serum aspartate aminotransferase (AST) and triglyceride (TG) levels were risk factors of erosive esophagitis in patients with chronic HBV infection. Conclusions Our findings indicate a close association between chronic HBV infection and GERD, especially in female subjects and those with higher APRI levels. Moreover, HBV carriers with higher AST or TG levels have higher incidence of erosive esophagitis. The interactions between chronic HBV infection and GERD need further studies.

show abstract

“…14,17,22,2 Furthermore, there is a stronger negative association between H. pylori infection and endoscopically-demonstrated reflux oesophagitis than between H. pylori and GORD without macroscopic oesophagitis. [26][27][28] …”

Section: H Pylori and Gord Complications In East Asiamentioning

confidence: 99%

Does Helicobacter pylori protect against oesophageal adenocarcinoma, and if so, how?

Atherton

2008

Clinical Medicine

View full text Add to dashboard Cite

Differences in Clinical Characteristics between Patients with Endoscopy-Negative Reflux Disease and Erosive Esophagitis in Japan

Abstract: Female gender, low BMI, not smoking, absence of hiatal hernia, and severity of gastric atrophy were positively associated with endoscopy-negative reflux disease compared with erosive esophagitis among Japanese patients.

Cited by 85 publications

References 36 publications

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Risk factors for gastroesophageal reflux disease, reflux esophagitis and non-erosive reflux disease among Chinese patients undergoing upper gastrointestinal endoscopic examination

Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection

Does Helicobacter pylori protect against oesophageal adenocarcinoma, and if so, how?

Contact Info

Product

Resources

About