Differences in clamp loader mechanism between bacteria and eukaryotes
Jacob T. Landeck,
Joshua Pajak,
Emily K. Norman
et al.
Abstract:SUMMARYClamp loaders are pentameric ATPases that place circular sliding clamps onto DNA, where they function in DNA replication and genome integrity. The central activity of a clamp loader is the opening of the ring-shaped sliding clamp, and the subsequent binding to primer-template (p/t)-junctions. The general architecture of clamp loaders is conserved across all life, suggesting that their mechanism is retained. Recent structural studies of the eukaryotic clamp loader Replication Factor C (RFC) revealed that… Show more
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