Abstract:Leishmania tarentolae is a non-pathogenic trypanosomatid isolated from lizards widely used for heterologous protein expression and extensively studied to understand the pathogenic mechanisms of leishmaniasis. The repertoire of leishmanolysin genes was reported to be expanded in L. tarentolae genome, but no proteolytic activity was detected. Here, we analyzed L. tarentolae leishmanolysin proteins from the genome to the structural levels and evaluated the enzymatic activity of the wild-type and overexpressing mu… Show more
“…Nevertheless, it can help delineate the underlying virulence and pathogenic mechanisms involved in human and animal leishmaniases. The repertoire of Leishmaniolysin genes in the genome of L. tarentolae was investigated by Ennes-Vidal et al [12], and a total of 61 leishmanolysin sequences were retrieved. These are phylogenetically more related to the L. major leishmaniolysin than the L. braziliensis and L. martiniquensis.…”
“…Nevertheless, it can help delineate the underlying virulence and pathogenic mechanisms involved in human and animal leishmaniases. The repertoire of Leishmaniolysin genes in the genome of L. tarentolae was investigated by Ennes-Vidal et al [12], and a total of 61 leishmanolysin sequences were retrieved. These are phylogenetically more related to the L. major leishmaniolysin than the L. braziliensis and L. martiniquensis.…”
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