Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States

Iqbal, Javaid; Ginsburg, Ophira; Rochon, Paula A.; Sun, Ping; Narod, Steven A.

doi:10.1001/jama.2014.17322

Cited by 521 publications

(483 citation statements)

References 21 publications

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“…Studies have found that tumour characteristics such as grade, hr status, and other unknown pathologic features vary with ethnicity, although no study has specifically included fn women 17,[42][43][44] . Among women diagnosed at stages ii-iv, we found a significant difference in grade and hr status for fn women compared with aom women.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

et al. 2016

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“…Unfortunately, the categorization of Latino origin in patients living in non-Latin American countries carry some bias as a large percentage of this population does not self-identify as Latino [6,7] ( Figure 1). BC incidence in Latinas is lower compared with the US white women (91.9 cases vs 128.1 per 100,000), although it is increasing [8]. Women living in Florida state with Puerto-Rican and Cuban background have higher rates of BC than with Mexican and from other Latin American countries' background.…”

mentioning

confidence: 88%

Genetics, Tumor Features and Treatment Response of Breast Cancer in Latinas

Castañeda

Castillo

Villarreal‐Garza

et al. 2018

Breast Cancer Manag.

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Practice pointsr Latinas with breast cancer have been associated with lower prevalence and higher mortality rates. r The access to healthcare system for Latinas has been described as lower than for white women. r Rates of grade III and triple-negative phenotype breast cancer are higher for Latinas than for white women. r BRCA mutation prevalence appears to be higher in Latinas than white women in the American population. r Distribution of BRCA mutation differs by country in Central, Latin America or Caribbean and recurrent mutations have been described in Mexico. r Finally, evaluated information about treatment efficacy and toxicity in Latinas with breast cancer indicate similar effects than in the white race.Breast cancer is a heterogeneous and genetic disease that has variability according to ethnicity and race with respect to incidence, clinical characteristics and prognosis. The incidence of breast cancer is lower but mortality is higher in Latinas than Caucasians in the US series. Risk factors appear to have different prevalence and impact in Latinas. Breast cancer in Latinas has particular clinic-pathological features including younger age, higher rates of triple-negative subtype and advanced stages. Molecular studies find that Latinas from every region have a specific BRCA incidence and a recurrent mutation, as well as differences in activity of molecular pathways. Treatment response rates and toxicity have also been compared, and no difference was found between Latinas and other ethnic groups.

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“…For mortality this may be due in part to the elevated breast and prostate cancer rates among black populations in the sub-region, combined with outcome disparities and an increased risk of death for both cancers, as reported in other settings. [14][15][16][17][18][19] Lung cancer was the first cause of death in two of the sub-regions but warrants cautious interpretation on considering the relatively low rates of lung cancer incidence and the fact that mortality should closely follow incidence given the consistently poor prognosis from this cancer. The underlying inferior quality of death certificates cannot be excluded as a possible explanatory artefact.…”

Section: 23mentioning

confidence: 99%

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

Bray¹,

Piñeros²

2016

Salud Publica Mex

116

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Objective. To develop a situation analysis encompassing the patterns and trends in cancer incidence and mortality in South and Central America and the Caribbean, with comparisons globally and with selected external countries. Materials and methods. Data on cancer incidence and mortality rates for 31 countries were obtained from the 2012 GLOBOCAN database. Incidence and mortality trends for selected countries were analysed with data from the Cancer Incidence in Five Continents (CI5) series and the WHO Mortality Database, respectively. Results. In 2012, almost 1.1 million new cancer cases were estimated annually, with important variations in rates across countries. The most common cancer types were breast, prostate, colorectum and lung cancer; stomach and cervical cancer ranked high in less developed countries. Increasing trends were observed in prostate, breast and colorectal cancer; lung cancer mortality trends diverged among males and females, while cervix cancer incidence and stomach cancer mortality uniformly decreased. A 66% increase in cancer cases in the region by 2030 is projected based on population aging and growth. Conclusions. Cancer patterns and trends reflect the significant sociodemographic changes in the region: the growing burden imposes great challenges to national health care systems to implement cancer control actions, while improving cancer surveillance to effectively measure the response.Keywords: cancer; mortality; incidence; Latin America ResumenObjetivo. Analizar la situación y tendencias en la incidencia y mortalidad por cáncer en América del Sur, Central y el Caribe, en comparación con patrones mundiales. Material y métodos. Los datos de incidencia y mortalidad por cáncer de 31 países se obtuvieron de la base de datos de GLOBOCAN 2012. Para analizar las tendencias de incidencia y mortalidad en países seleccionados, los datos se obtuvieron de la serie Incidencia de Cáncer en Cinco Continentes (CI5) y de la base de datos de mortalidad de la OMS, respectivamente. Resultados. En 2012, se estimaron casi 1.1 millones de nuevos casos de cáncer al año, con variaciones importantes en las tasas entre los distintos países. Los tipos de cáncer más comunes fueron cáncer de mama, próstata, colon y recto, y de pulmón; los cánceres de estómago y cuello uterino ocuparon puestos altos en los países menos desarrollados. Se observaron tendencias crecientes en cáncer de próstata, mama y colorrectal; las tendencias de mortalidad por cáncer de pulmón presentaron tendencias divergentes entre hombres y mujeres, mientras que la incidencia de cáncer de cuello uterino y la mortalidad por cáncer de estómago disminuyeron. Para el año 2030 se espera un incremento del 66% en los casos de cáncer. Conclusiones. Los patrones y tendencias del cáncer reflejan los importantes cambios sociodemográficos en la región e imponen grandes desafíos a los sistemas de salud para responder a la creciente carga, así como para mejorar la vigilancia del cáncer.

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Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States

Cited by 521 publications

References 21 publications

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

Genetics, Tumor Features and Treatment Response of Breast Cancer in Latinas

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

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