Differences in Breast Cancer Between Japan and the United States 2

Abstract

Two surgically treated series of 375 Japanese and 352 American women with breast cancer were compared with respect to overall survival and recurrence-free survival rates. Recurrence-free survival rates in Japanese women were superior to those in American women. Overall survival rates were also better in Japanese women, although the difference was not nearly as great as for recurrence-free survival. This seemed due to an improved survival after metastasis in the American women. In analyzing recurrence-free survival rates by age, we found that Japanese women 40 to 54 years old had better recurrence-free survival rates than other age subgroups. This age advantage was not observed in American women. For other age groups, there was relatively little advantage in survivorship in the Japanese series.

Comparative Effects of Piroxicam and Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12-Dimethylbenz[a]anthracene in Rats on High- and Low-Fat Diets

“…The incidence and prognosis of breast cancer differs between Western and Japanese women [30][31][32] [44] found that indomethacin inhibited growth of cultured human mammary fibroadenoma cells and that this inhibition was not reversed by prostaglandin E2. In an in vivo study.…”

A breast cancer nutrition adjuvant study (NAS): Protocol design and initial patient adherence

“…These studies include nutritional epidemiologic analysis, migrant studies, time-trend studies, retrospective case-control studies, and analyses of populations with distinct nutritional intakes [2,6,9,17,19,20,27,31]. A variety of animal studies also support an association between dietary fat intake and mammary cancer development [10,16,28].…”

Nutritional etiology of breast cancer: Where are we now, and where are we going?

“…These observations might well be linked with a number of reports relating nutritional factors with tumor behavior after diagnosis (e.g., Morrison et al [8] and Nemoto et al [9] have reported a worse prognosis of breast cancer in American women than in Japanese women) and with other reports documenting the adverse role of overweight in breast cancer survival [10][11][12].…”