Differences in Brain Volume, Hippocampal Volume, Cerebrovascular Risk Factors, and Apolipoprotein E4 Among Mild Cognitive Impairment Subtypes

He, Jing; Farias, Sarah E Tomaszewski; Martinez, Oliver; Reed, Bruce R; Mungas, Dan M; DeCarli, Charles

doi:10.1001/archneurol.2009.252

Cited by 87 publications

(69 citation statements)

References 60 publications

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“…As in some previous studies (Whitwell et al 2007;He et al 2009;Zhang et al 2012), where a-MCI subtypes were compared, we failed to find significant statistical differences in hippocampal volumes. However, in a follow-up study, Tabert et al (2006) found that 38 out of 39 patients that converted to AD had a baseline diagnosis of a-md-MCI, while none of them had a baseline diagnosis of a-sd-MCI.…”

Section: Discussionsupporting

confidence: 52%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

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Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and AGE (2014) compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

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Section: Discussionsupporting

confidence: 52%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

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“…These neuropathological features could be considered intermediate between normal aging and early AD (Petersen et al 2006;He et al 2009;Zhang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study

López

Garcés

Cuesta

et al. 2014

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Mild cognitive impairment (MCI) is a stage between healthy aging and dementia. It is known that in this condition the connectivity patterns are altered in the resting state and during cognitive tasks, where an extra effort seems to be necessary to overcome cognitive decline. We aimed to determine the functional connectivity AGE (2014) pattern required to deal with an internally directed cognitive state (IDICS) in healthy aging and MCI. This task differs from the most commonly employed ones in neurophysiology, since inhibition from external stimuli is needed, allowing the study of this control mechanism. To this end, magnetoencephalographic (MEG) signals were acquired from 32 healthy individuals and 38 MCI patients, both in resting state and while performing a subtraction task of two levels of difficulty. Functional connectivity was assessed with phase locking value (PLV) in five frequency bands. Compared to controls, MCIs showed higher PLV values in delta, theta, and gamma bands and an opposite pattern in alpha, beta, and gamma bands in resting state. These changes were associated with poorer neuropsychological performance. During the task, this group exhibited a hypersynchronization in delta, theta, beta, and gamma bands, which was also related to a lower cognitive performance, suggesting an abnormal functioning in this group. Contrary to controls, MCIs presented a lack of synchronization in the alpha band which may denote an inhibition deficit. Additionally, the magnitude of connectivity changes rose with the task difficulty in controls but not in MCIs, in line with the compensation-related utilization of neural circuits hypothesis (CRUNCH) model.

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“…Cases of nonamnestic MCI are thought to have increased vascular burden as well as focal atrophy of basal forebrain and hypothalamus. [32][33][34][35] In contrast to gray matter, MR imaging investigations of WM integrity in MCI subtypes are still very rare. [36][37][38] They neither included the whole spectrum of MCI subtypes nor explored the usefulness of DTI parameters on the individual classification of cases of MCI.…”

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confidence: 99%