Differences in Brain Natriuretic Peptide and Other Factors between Japanese Peripheral Arterial Disease Patients with Critical Limb Ischemia and Intermittent Claudication

Kumakura, Hisao; Kanai, Hiroyuki; Araki, Yoshihiro; Hojo, Yoshiaki; Kasama, Shu; Sumino, Hiroyuki; Iwasaki, Tadaaki; Takayama, Yoshiaki; Ichikawa, Shûichi; Fujita, K; Nakashima, Kuniki; Minami, Kazutomo

doi:10.5551/jat.18929

Cited by 16 publications

(19 citation statements)

References 40 publications

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“…[16,17] Several studies have investigated NPR-B as it relates to inducible ischemia types. [5,18] Staub et al [5] suggested that it might have diagnostic value in the determination of inducible myocardial ischemia, and Kumakura et al [7] reported that high NPR-B levels correlated with a number of affected distal arteries in critical limb ischemia. Furthermore, Montagnana et al [19] found that NT-prohormone-brain natriuretic peptide (NT-proBNP) was substantially increased in peripheral arterial disease (PAD) patients.…”

Section: Discussionmentioning

confidence: 99%

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Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia

Çalışkan¹

2014

Turk Gogus Kalp Dama

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Section: Discussionmentioning

confidence: 99%

“…[5] In addition, Nadir et al [6] demonstrated that natriuretic peptides can be helpful for determining the efficacy of anti-ischemic therapy and risk factor classification. In addition, Kumakura et al [7] found high levels of BNP in the limbs of critical ischemia patients.…”

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confidence: 99%

Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia

Çalışkan¹

2014

Turk Gogus Kalp Dama

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“…The prevalence of aspirin, clopido- high-sensitivity C-reactive protein, Total-C: total cholesterol, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein cholesterol, RLP-C: remnant-like particle cholesterol, TAT: thrombin-antithrombin complex, PIC: plasmin-2 plasmin inhibitor complex, BNP: brain natriuretic peptide, ACE: angiotensin-converting enzyme, ARB: angiotensin receptor blocker tion, the fibrinogen level is particularly associated with the severity and potential for the further development of PAD 26) and functions as an independent risk factor for CAD 25) . Hyperhomocysteinemia is an independent risk factor for atherosclerosis and a stronger risk factor for PAD than for CAD 16,17) , with an association with death or severe vascular events in patients with PAD 27) . We previously found that a high plasma homocysteine level is also a risk factor for CLI as well as PAD 17) .…”

Section: Discussionmentioning

confidence: 99%

“…Hyperhomocysteinemia is an independent risk factor for atherosclerosis and a stronger risk factor for PAD than for CAD 16,17) , with an association with death or severe vascular events in patients with PAD 27) . We previously found that a high plasma homocysteine level is also a risk factor for CLI as well as PAD 17) . Furthermore, Masuda et al 28) showed that diabetic subjects have higher homocysteine levels and that homocysteine has significant relationships with eGFR, Our results provide the first evidence that hs-CRP, Lp(a) and homocysteine are independent risk factors for concomitant CAD in Japanese patients with PAD.…”

Section: Discussionmentioning

confidence: 99%

“…Homocysteine is an intermediate metabolite of methionine that contributes to cardiovascular disease via mechanisms such as endothelial dysfunction, increased lipid permeability and vascular inflammation 14,15) . Hyperhomocysteinemia is an independent risk factor for PAD and CAD 16,17) . Hence, the combination of high homocysteine and Lp(a) levels synergistically increases the likelihood of developing CAD 15) .…”

Section: Introductionmentioning

confidence: 99%

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High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Kumakura

Fujita

Kanai

et al. 2015

JAT

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Aim:The goal of the study was to investigate the relationships between coronary artery disease (CAD) and risk factors, including the serum levels of high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) (Lp(a)) and homocysteine, in Japanese patients with peripheral arterial disease (PAD). Methods: Coronary angiography was performed in 451 patients with PAD, among whom the prevalence and clinical characteristics of CAD were analyzed. A multiple logistic analysis was used to evaluate the relationships between CAD and the risk factors. The relationships between the severity of coronary arterial lesions and the risk factors were evaluated using multiple regression analysis. Results: The prevalence of CAD (≥ 70% luminal diameter narrowing or a history of CAD) and coronary artery stenosis (≥ 50%) was 55.9% and 74.1%, respectively, and the rate of CAD (≥ 70%) with single-, double-and triple-vessel disease was 25.9%, 13.5% and 10.6%, respectively. The prevalence of diabetes was higher among the patients with CAD than among those without. The serum levels of hs-CRP, Lp(a), and homocysteine were higher in the patients with CAD, whereas the estimated glomerular filtration rates and HDL-cholesterol levels were lower in these patients. According to the multiple logistic analysis, CAD was related to diabetes (hazard ratio [

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Myocardial injury after endovascular revascularization in critical limb ischemia predicts 1-year mortality: a prospective observational cohort study

et al. 2017

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BackgroundPatients with critical limb ischemia (CLI) are at increased risk of cardiovascular complications and mortality. To determine (1) incidence of myocardial injury following endovascular revascularization, and (2) relationship between myocardial injury with 1-year mortality and major adverse cardiovascular events (MACE; i.e., composite of myocardial infarction, stroke, and death).Methods and resultsSingle-center, prospective cohort study of CLI patients ≥ 45 years of age, who underwent endovascular revascularization with overnight hospitalization. High-sensitive troponins T (hsTnTs) were measured on admission, 3–6 h after endovascular revascularization and the subsequent morning. Myocardial injury after endovascular revascularization was defined as an hsTnT ≥ 14 ng/L with a relative increase ≥ 30% from the baseline value. We also evaluated other myocardial injury hsTnT thresholds (i.e., ≥ 30, ≥ 40, ≥ 60, and ≥ 80 ng/L). 239 consecutive patients (56% male, mean age 71.5 ± 10.1 years) were included; one patient was lost to follow-up. At 1 year, there were 34 deaths (14.2%), and 48 MACE (20.5%). Myocardial injury with the hsTnT threshold of 14 ng/L and relative increase by ≥ 30% from the baseline level occurred in 61 patients (25.5%). Myocardial injury was independently associated with 1-year mortality ([aHR], 2.44; 95% CI 1.18–5.06, for hsTnT ≥ 14 ng/L to aHR, 3.34; 95% CI 1.29–8.65 for hsTnT ≥ 80 ng/L). Myocardial injury was also independently associated with 1-year MACE ([AOR] 2.89; 95% CI 1.41–5.92 for hsTnT ≥ 14 ng/L to AOR, 6.69; 95% CI 2.17–20.68 for hsTnT ≥ 80 ng/L). 85.2% patients who had myocardial injury did not have ischemic clinical symptoms or electrocardiography changes. In sensitive analysis with exclusion of symptomatic patients that developed myocardial injury for the hsTnT ≥ 14 ng/L threshold, both the 1-year mortality (aHR: 2.19; CI 1.02–4.68; p = 0.04), and 1-year MACE (OR 2.25; CI 1.06–4.77; p = 0.036) remained significant.ConclusionsMyocardial injury is common following endovascular revascularization for CLI and associated with the risk of 1-year mortality and MACE.

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Differences in Brain Natriuretic Peptide and Other Factors between Japanese Peripheral Arterial Disease Patients with Critical Limb Ischemia and Intermittent Claudication

Abstract: A high BNP level, diabetes, female gender, a low albumin level, ABI and BMI are risk factors for CLI. In this study, differences in the levels of anatomical lesions and correlated risk factors were found between the CLI and IC groups.

Cited by 16 publications

References 40 publications

Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia

Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Myocardial injury after endovascular revascularization in critical limb ischemia predicts 1-year mortality: a prospective observational cohort study

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