Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level

Brook, Robert D.; Bard, Robert L.; Burnett, Richard T.; Shin, Hwashin Hyun; Vette, Alan; Croghan, Carry; Phillips, M.; Rodes, Charles; Thornburg, Jonathan; Williams, Ron

doi:10.1136/oem.2009.053991

Cited by 135 publications

(112 citation statements)

References 38 publications

(62 reference statements)

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“…These findings were consistent with the results from a population-based prospective cohort study that observed the long-term effects of PM 2.5 exposure on arterial SBP and DBP after controlling for noise exposure among adults aged 45-75 years with 14% diabetes mellitus (Fuks et al, 2011). However, only increased SBP was reported in two other previous studies; they did not take into account noise and NO x exposure (Brook et al, 2011;Dvonch et al, 2009). These inconsistent results might be due to different approaches to exposure assessment and different strategies for measuring blood pressure (i.e., resting vs. ambulatory).…”

Section: Discussionsupporting

confidence: 91%

“…Noise exposure above 55 A-weighted decibels (dBA) may increase systolic blood pressure (SBP) and diastolic blood pressure (DBP) in young and middle-aged adults (Chang et al, 2009(Chang et al, , 2015. Short-term exposure to PM 2.5 was associated with increased SBP (Brook et al, 2011;Dvonch et al, 2009). Doubling NO x exposure during one year preceding enrollment was associated with decreased SBP (Sorensen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Short-term exposure to noise, fine particulate matter and nitrogen oxides on ambulatory blood pressure: A repeated-measure study

Chang

Chuang

Yang

et al. 2015

Environmental Research

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Short-term exposure to noise, fine particulate matter and nitrogen oxides on ambulatory blood pressure: A repeated-measure study

Chang

Chuang

Yang

et al. 2015

Environmental Research

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“…Таким образом, субмикронные и нано-размерные аэрозоли присутствовали в атмосфере задолго до нанотехнологического бума и продолжают представ-лять серьезную проблему для здоровья людей. Основной вектор современных исследований токсических эффектов наночастиц и наноаэрозолей направлен на изучение их поражающего воздействия на респираторную и сердечно сосудистую системы (Donaldson et al, 2002;Chen et al, 2008;Brook et al, 2010;Kampfrath et al, 2011). При этом респираторная система рассматривается в качестве одной из основных портальных систем для поступления наноча-стиц в организм.…”

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Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles

Romashchenko¹,

Petrovskii²,

Sharapova³

et al. 2017

Vestn. VOGiS

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The ability to deliver particulated xenobiotics and therapeutic drugs directly from the nasal cavity to the central nervous system, bypassing the hemato-encephalic barrier, determines a high importance of investigation of factors influencing this process. It was shown that the bioavailability of solid particles is influenced by their size and surface charge. At the same time, the impact of a crystal structure (crystalline/amorphous) has been poorly investigated. In this study, using sexually mature male C57BL/6J mice, we analyzed the efficiency of the nose-to-brain transport of crystalline and amorphous manganese oxide nanoparticles. T1-weighted magnetic resonance imaging (MRI) was used to evaluate the accumulation of manganese nanoparticles in olfactory bulb (OB) and olfactory epithelium (OE). So, it has been established that amorphous particles have higher accumulation rate in OE and OB in comparison with crystalline particles after their intranasal administration. The unequal ability of amorphous and crystalline particles to overcome the mucosal layer covering the OE may be one of the possible reasons for the different nose-to-brain transport efficiency of particulated matter. Indeed, the introduction of mucolytic (dithiothreitol) 20 minutes prior to intranasal particle application did not influence the accumulation of amorphous particles in OE and OB, but enhanced the efficiency of crystalline nanoparticle entry. Data on the different intake of amorphous and crystalline nanoparticles from the nasal cavity to the brain, as well as the evidence for the key role of the mucosal layer in differentiating the penetrating power of these particles will be useful in developing approaches to assessing air pollution and optimizing the methods of inhalation therapy.Key words: amorphous and crystalline nanoparticles; olfactory transport; mucosal layer; magnetic resonance imaging.Известно, что наноразмерные твердые аэрозоли способны посту-пать из носовой полости в мозг в обход гематоэнцефалического барьера. Необходимость исследования факторов, влияющих на назальный транспорт наночастиц, обусловлена тем, что таким образом в мозг могут проникать как ксенобиотики, так и терапев-тические препараты. Показано, что биодоступность твердых час-тиц определяет их размер и поверхностный заряд. Вместе с тем влияние структуры кристаллической решетки практически не исследовано. В данной работе, выполненной на половозрелых самцах мышей C57BL/6J, проанализирована эффективность поступ-ления в ольфакторный эпителий (ОЭ) и обонятельные луковицы (ОЛ) интраназально апплицированных наночастиц оксидов мар-ганца с аморфной и кристаллической структурой. Для оценки на-коп ления магнито-контрастных наночастиц марганца в ОЛ и ОЭ ис-пользовали Т1-взвешенную магнитно-резонансную томографию. Установлено, что аморфные частицы накапливаются в ОЭ и ОЛ в большей степени, чем кристаллические. Одной из причин различ-ного поступления в головной мозг интраназально введенных нанообъектов может быть неодинаковая способность аморфных и кристалических частиц преодол...

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“…6 In recent years, several studies have investigated the shortterm effects of ambient air pollutants in the development of high BP and hypertension among humans, but the results of these studies are inconstant. Evidence from studies conducted in the United States, [7][8][9][10] Brazil, 11 and Taiwan 12 indicated that short-term increases in particulate matter (PM), organic carbon, black carbon, and ozone (O 3 ) air pollution lead to acute but transient increase in arterial BP and hypertension prevalence. However, results from 1 recent study conducted on 9238 nonsmoking adults >30 years of age indicated that shortterm exposure to particles with an aerodynamic diameter ≤10 µm (PM 10 ), sulfur dioxide (SO 2 ), nitrogen dioxides (NO 2 ), CO, and O 3 consistently reduced the systolic BP (SBP) and pulse pressure, whereas the diastolic BP (DBP) was increased by SO 2 , NO 2 , and O 3 .…”

mentioning

confidence: 99%

Association Between Long-Term Air Pollution and Increased Blood Pressure and Hypertension in China

Qian²,

et al. 2013

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http://hyper.ahajournals.org/ Downloaded from Dong et al Effects of Air Pollution on Blood Pressure 579pollution on BP in different parts of the world are unclear but may result from spatial and temporal variability in pollution sources and composition. 17,18 Compared with short-term effects of air pollution, there is little information on the relation between chronic exposure to air pollution and prevalent hypertension. Inconsistent results have also been reported on the association between incident hypertension and air pollution. For instance, Coogan et al 19 showed in a 10-year follow-up for incident hypertension and diabetes mellitus of black women from Los Angeles that NO X (but less PM 2.5 ) borderline increased the risk of becoming hypertensive. However, Sørensen et al 20 reported that longterm exposure (1 and 5 years) to NO X was not associated with incident self-reported hypertension in a Danish cohort. We hypothesized that at the population level, long-term exposure to ambient air pollution is associated with higher BP and higher prevalence of hypertension among humans. In this study, we tested this hypothesis in the 11 Districts Chinese Study, a cross-sectional study of air pollution and adult health in a large, well-characterized population-based sample, residing in northeast China, where there are wide differences in inter-and intracity gradients and ambient pollutant levels, offering a valuable opportunity to assess the associations between exposure and response. Methods Study Cities Selection and Subject RecruitmentMore than 20 million people reside in 14 cities in Liaoning province in northeast China. To maximize the inter-and intracity gradients of the pollutants of interest and minimize the correlation between district-specific ambient pollutants, in April 2009, we selected 3 cities (Shenyang, Anshan, and Jinzhou) based on the results of air pollution measurements between 2006 and 2008. There are 5, well-identified geographic districts in Shenyang, and 3 districts in Anshan and Jinzhou, respectively. Three communities within 1 km of air-monitoring sites were randomly chosen from these districts resulting in 33 locales, and from each of these, 700 to 1000 households were randomly identified. One participant, aged 18 to 74 years, was selected from each household without replacement. Our entry criterion was that the subject should have lived at that place for at least 5 years. The design and conduct of this investigation was reviewed and approved by Human Studies Committee of China Medical University. Before data collection, a written informed consent form was obtained from each participant. Ambient Air PollutionIn each of the selected study districts, there was only 1 municipal air pollution monitoring station, which was located 1 mile from the participants' homes. Measurements of PM 10 , SO 2 , NO 2 , and O 3 concentrations from 2006 to 2008 were obtained at the stations. The measurements were subject to uniform criteria for monitoring, siting, instrumentation, and quality assurance. Thes...

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Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level

Cited by 135 publications

References 38 publications

Short-term exposure to noise, fine particulate matter and nitrogen oxides on ambulatory blood pressure: A repeated-measure study

Short-term exposure to noise, fine particulate matter and nitrogen oxides on ambulatory blood pressure: A repeated-measure study

Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles

Association Between Long-Term Air Pollution and Increased Blood Pressure and Hypertension in China

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