Differences in bilirubin isomer composition in infants treated with green and white light phototherapy

Ennever, John F.; Knox, Isabella; Speck, William T.

doi:10.1016/s0022-3476(86)80590-x

Cited by 29 publications

(16 citation statements)

References 16 publications

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“…Vecchi and his co-workers have found that fluorescent green light is more effective than broad-spectrum white light in the treatment of neonatal jaundice (21). We have shown that lumirubin concentrations are higher and configurational isomer concentrations are lower in infants treated with green light compared with infants treated with white light (22). Thus, these results also support the conclusion that lumirubin excretion during phototherapy is important.…”

Section: Discussionsupporting

confidence: 84%

Rapid clearance of a structural isomer of bilirubin during phototherapy.

Ennever¹,

Costarino²,

Polin³

et al. 1987

J. Clin. Invest.

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During phototherapy for neonatal jaundice, bilirubin is converted into a variety of photoproducts. Determination of the relative importance of these photoproducts to the elimination of bilirubin requires knowledge of their rates of excretion. We have measured the rate at which the structural isomer of bilirubin, lumirubin, disappeared from the serum of nine jaundiced premature infants after the cessation of phototherapy. In all patients studied, the decline in serum lumirubin could be approximated by a firstorder rate equation with a half-life of 80 to 158 min. This rate of disappearance is much faster than that previously determined for the other major bilirubin photoproducts. In samples of bile aspirated from the duodenum of infants undergoing phototherapy, lumirubin was the principal bilirubin photoproduct found. These results indicate that formation and excretion of lumirubin is an important route for bilirubin elimination during phototherapy.

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Section: Discussionsupporting

confidence: 84%

Rapid clearance of a structural isomer of bilirubin during phototherapy.

Ennever¹,

Costarino²,

Polin³

et al. 1987

J. Clin. Invest.

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“…Therefore one can assume that the most efficient wavelength for phototherapy is close to the green part of the spectrum. Several studies support this (1 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], but others present arguments against the efficiency of green light based on clinical observations (21,22). The interpretation of clinical data should be done with great care, since not all studies have taken into account the difference in light output from the lamps.…”

Section: Discussionmentioning

confidence: 99%

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

et al. 1994

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Cultured cells from one human and one murine cell line were treated with bilirubin and irradiated with visible light of different wavelengths, either from phototherapy lamps or from a Xenon/Mercury lamp equipped with a monochromator. Bilirubin bound to human serum albumin was also irradiated with light. After irradiation, the bilirubin and its photoisomers were extracted and analysed with High Pressure Liquid Chromatography. The formation of single strand breaks in the DNA of treated cells was studied using a fluorescence marker. Cytotoxicity in the mouse skin cell line was measured by loss of the ability to form visible colonies in vitro. Green light exposure favours the production of lumirubin, while blue light causes more DNA damage and cytotoxicity. Green light may be more efficient and safer than shorter wavelength exposure when treating jaundiced newborns with phototherapy.

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“…However, the rapid and more selective effect obtained with this light in the photoisomerization process could be responsible for more pronunced rebound observed after stopping blue PT. Wavelengths in the green light spectrum may be more effective in enhancing lumirubin formation which is apparently excreted more readily than other photoisomers [9,10].…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of high intensity green light phototherapy in the treatment of neonatal jaundice

Amato

Inaebnit

1991

Eur J Pediatr

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Two matched groups of term newborn infants with idiopathic jaundice were subjected to intensive double direction green or blue light phototherapy (PT). The efficacy of treatment was expressed as rate of decline of serum bilirubin concentration after 6, 12 and 24 h of light exposure. More rapid response was obtained using conventional blue lamps (Philips TL/20W/52) than green lamps (Sylvania F20T12/G). Whole duration of PT was significantly shorter using blue lamps (P less than 0.05). However, less postphototherapy rebound was observed in babies treated with green light PT. It can be concluded that green light PT is useful but not preferable to blue light PT for clinical use in the treatment of neonatal jaundice.

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Differences in bilirubin isomer composition in infants treated with green and white light phototherapy

Cited by 29 publications

References 16 publications

Rapid clearance of a structural isomer of bilirubin during phototherapy.

Rapid clearance of a structural isomer of bilirubin during phototherapy.

Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

Clinical usefulness of high intensity green light phototherapy in the treatment of neonatal jaundice

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