Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease

Hsu, Cynthia L.; Wang, Yanhan; Duan, Yi; Chu, Huikuan; Hartmann, Phillipp; Llorente, Cristina Castilla; Zhou, Rongrong; Schnabl, Bernd

doi:10.1007/s10620-023-07860-1

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…NAFLD prevalence is rising globally, partly due to the prevalence of metabolic diseases, such as insulin resistance, type 2 diabetes, and overweight or obesity [ 51 ]. Furthermore, alcohol and high-fat and high-fructose diets can promote intestinal permeability, allowing microorganisms to migrate from the intestine to the liver [ [52] , [53] , [54] , [55] ]. In addition, the host's metabolism status, including drug and dietary metabolism, can affect the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bibliometric and visualized analysis of research on gut-liver axis published from 1998 to 2022

Wen,

Zhang,

Zhang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Comprehensive bibliometric and visualized analysis of research on gut-liver axis published from 1998 to 2022

Wen,

Zhang,

Zhang

et al. 2024

Heliyon

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“…Once activated, TLR signaling cascades can promote hepatic inflammation by activating nuclear factor‐κB and the production of inflammatory cytokines such as tumor necrosis factor‐α and interleukin (IL)‐1β by Kupffer cells and hepatic fibrosis by activating transforming growth factor‐β in hepatic stellate cells. Translocation of viable bacteria can also occur once the protective intestinal barrier is disrupted in chronic alcohol use 29,30 . This may contribute to decompensation of liver disease, as Enterobacteriaceae are the most common bacteria detected in ascites fluid samples from patients with cirrhosis 24 …”

Section: Gut Bacteria and Alcohol‐associated Liver Diseasementioning

confidence: 99%

“…Translocation of viable bacteria can also occur once the protective intestinal barrier is disrupted in chronic alcohol use. 29,30 This may contribute to decompensation of liver disease, as Enterobacteriaceae are the most common bacteria detected in ascites fluid samples from patients with cirrhosis. 24 Some gut microbes such as Akkermansia muciniphila directly promote intestinal barrier function by maintaining the mucus layer through mucus production.…”

Section: Gut Bacteria and Alcohol-associated Liver Diseasementioning

confidence: 99%

Alcohol, the gut microbiome, and liver disease

Jew

Hsu

2023

J of Gastro and Hepatol

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The microorganisms inhabiting our gastrointestinal tract are critical for human health. Chronic heavy alcohol use can modulate the composition and function of the gut microbiota, thereby exacerbating end-organ damage via the gut-brain axis and the gut-liver axis. In this review, we summarize the bacterial, fungal, and viral gut microbial compositional changes associated with alcohol use and alcohol-associated liver disease and discuss the mechanisms of action by which gut dysbiosis reinforces alcohol use behavior and liver inflammation and injury. We also highlight important pre-clinical and clinical trials that target gut microbial-specific mechanisms for the treatment of alcohol use disorder and alcohol-associated liver disease.

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“…Liver injury was significantly positively correlated with serum lipopolysaccharides (LPS) in HFD-induced steatohepatitis model mice. [6] Significant changes in gut microbiota composition were found in patients with NAFLD, [7] and gut permeability had been increased in patients with NAFLD and nonalcoholic steatohepatitis. [8,9] The intestinal flora and gut barrier, which are important components of the gut-liver axis, can prevent endotoxins from entering the liver.…”

Section: Introductionmentioning

confidence: 96%

“…Gut dysbiosis is also associated with changes in metabolites produced by intestinal microbiota, which can also contribute to gut barrier dysfunction and liver disease. Liver injury was significantly positively correlated with serum lipopolysaccharides (LPS) in HFD‐induced steatohepatitis model mice [6] . Significant changes in gut microbiota composition were found in patients with NAFLD, [7] and gut permeability had been increased in patients with NAFLD and nonalcoholic steatohepatitis [8,9] …”

Section: Introductionmentioning

confidence: 99%

Dendrobium huoshanense Polysaccharide Improves High‐Fat Diet Induced Liver Injury by Regulating the Gut‐Liver Axis

Ma,

Gao,

Chen

et al. 2023

Chemistry & Biodiversity

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Dendrobium huoshanense is an important Traditional Chinese medicine that thickens the stomach and intestines. Its active ingredient Dendrobium huoshanense polysaccharide (DHP), was revealed to relieve the symptoms of liver injury. However, its mechanism of action remains poorly understood. This study aimed to investigate the mechanism of DHP in protecting the liver. The effects of DHP on lipid levels, liver function, and intestinal barrier function were investigated in mice with high‐fat diet‐induced liver damage. Changes in the gut flora and their metabolites were analyzed using 16S rRNA sequencing and metabolomics. The results showed that DHP reduced lipid levels, liver injury, and intestinal permeability. DHP altered the intestinal flora structure and increased the relative abundance of Bifidobacterium animalis and Clostridium disporicum. Furthermore, fecal metabolomics revealed that DHP altered fecal metabolites and significantly increased levels of gut‐derived metabolites, spermidine, and indole, which have been reported to inhibit liver injury and improve lipid metabolism and the intestinal barrier. Correlation analysis showed that spermidine and indole levels were significantly negatively correlated with liver injury‐related parameters and positively correlated with the intestinal species B. animalis enriched by DHP. Overall, this study confirmed that DHP prevented liver injury by regulating intestinal microbiota dysbiosis and fecal metabolites.

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Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease

Cited by 12 publications

References 31 publications

Comprehensive bibliometric and visualized analysis of research on gut-liver axis published from 1998 to 2022

Comprehensive bibliometric and visualized analysis of research on gut-liver axis published from 1998 to 2022

Alcohol, the gut microbiome, and liver disease

Dendrobium huoshanense Polysaccharide Improves High‐Fat Diet Induced Liver Injury by Regulating the Gut‐Liver Axis

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