Differences in anxiety and depression symptoms: comparison between older and younger clinical samples

Wuthrich, Viviana M.; Johnco, Carly; Wetherell, Julie Loebach

doi:10.1017/s1041610215000526

Cited by 67 publications

(12 citation statements)

References 30 publications

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“…The discordance in the findings of various studies may be due to the different approaches to assess anxiety or differences in treatment (e.g., some antidepressants may be more efficacious in treating depression with comorbid anxiety symptoms). This is important because, compared to younger adults, older adults may be more likely to have worry symptoms, but less likely to have fear/panic symptoms (Lenze & Wetherell, ; Wuthrich et al, ) Still, our findings contradict a prior study by our group in depressed elderly patients (>70‐year old; Andreescu et al, ) in which response to treatment with paroxetine was lower among patients with high worry symptoms.…”

Section: Discussioncontrasting

confidence: 88%

“…Our study had some limitations: it was an open‐label study, with no placebo or comparison treatment arm. Also, anxiety was based on clinical questionnaires that may be subject to reporting biases and underreporting of anxiety in older adults (Lenze & Wetherell, ; Wuthrich et al, ). In addition, we chose to measure panic/fear symptoms with a measure of anxiety sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…This distinction is important because of neuroimaging and genetic evidence that these two phenotypes are distinct (Martin, Ressler, Binder, & Nemeroff, ). Moreover, despite the chronicity of both these disorders, there is some evidence that fear symptoms (e.g., panic) decline with aging, while worry symptoms may be more common in older depressed individuals (Jeste, Hays, & Steffens, ; Schaakxs, Comijs, Lamers, Beekman, & BWJH., ; Wuthrich, Johncol, & Wetherell, ). Time and experience are thought to aid in the development of emotional regulation (Jarvik & Russell, ).…”

Section: Introductionmentioning

confidence: 99%

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Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

et al. 2019

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Objective: The purpose of this study was to examine the influence of comorbid anxiety symptoms on antidepressant treatment remission in older adults with major depressive disorder (MDD). Method: In this multisite clinical trial, 468 older adults aged 60 years or older with MDD received open-label protocolized treatment with venlafaxine extended release (ER) titrated to a maximum of 300 mg daily. At baseline, anxiety was assessed with the Anxiety Sensitivity Index, the Brief Symptom Inventory (BSI) anxiety subscale, and the Penn State Worry Questionnaire. To measure treatment response, depressive symptoms and suicidality were assessed every 1-2 weeks with the Montgomery-Asberg Depression Rating Scale and the 19-item Scale for Suicide Ideation; anxiety was assessed with the BSI. Logistic regression and survival analysis were used to evaluate whether anxiety symptoms predicted depression remission.We also examined the relationships between anxiety scores and suicidality at baseline.Results: Baseline anxiety symptoms did not predict remission or time to remission of depressive symptoms. Depressive, worry, and panic symptoms decreased in parallel in patients with high anxiety. Anxiety symptoms were associated with the severity of depression and with suicidality.Conclusion: In older adults with MDD, comorbid anxiety symptoms are associated with symptom severity but do not affect antidepressant remission or time to remission. K E Y W O R D S antidepressants, anxiety/anxiety disorders, depression, geriatric/aging/elderly, suicide/self-harm Institute of Mental Health (R01 MH083660 and P30 MH90333 to University of Pittsburgh, R01 MH083648 to Washington University, and R01 MH083643 to University of Toronto).

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Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

et al. 2019

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“…The English language version of this 16-item scale asks participants how “concerned” they are, on a 4-point Likert scale, about falling while carrying out various activities (e.g., cleaning the house, taking a bath or shower, walking on an uneven surface). Although the FES-I is conceptualized as a measure of fall-related self-efficacy, the English version uses the word “concern,” which is a term often used by older adults to indicate anxiety (32). Because anxiety and fear are related constructs, and because the FES-I is well validated and frequently used, we chose it as our measure of fear of falling.…”

Section: Methodsmentioning

confidence: 99%

Integrated Exposure Therapy and Exercise Reduces Fear of Falling and Avoidance in Older Adults: A Randomized Pilot Study

Wetherell

Bower

Johnson

et al. 2018

The American Journal of Geriatric Psychiatry

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“…Interestingly, the existence of an age difference in the expression of anxiety between young and aged mouse lemurs is similar to the difference found in humans. Indeed, even if the prevalence of anxiety disorders over the lifespan is debated (Baxter et al, 2013; Miloyan et al, 2014), it seems clear that a difference in the expression of anxiety behaviors exists in aging humans (Wuthrich et al, 2015). Interestingly, a study focusing on age differences in mental disorders in ten different European countries (McDowell et al, 2014) reported a lower prevalence of mood and anxiety disorders in older adults than in young adults in western European countries.…”

Section: Potential Markers Of Behavioral and Psychological Symptoms Omentioning

confidence: 99%

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

2019

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To face the load of the prevalence of Alzheimer’s disease in the aging population, there is an urgent need to develop more translatable animal models with similarities to humans in both the symptomatology and physiopathology of dementia. Due to their close evolutionary similarity to humans, non-human primates (NHPs) are of primary interest. Of the NHPs, to date, the gray mouse lemur (Microcebus murinus) has shown promising evidence of its translatability to humans. The present review reports the known advantages and limitations of using this species at all levels of investigation in the context of neuropsychiatric conditions. In this easily bred Malagasy primate with a relatively short life span (approximately 12 years), age-related cognitive decline, amyloid angiopathy, and risk factors (i.e., glucoregulatory imbalance) are congruent with those observed in humans. More specifically, analogous behavioral and psychological symptoms and neuropsychiatric symptoms of dementia (BPSD/NPS) to those in humans can be found in the aging mouse lemur. Aged mouse lemurs show typical age-related alterations of locomotor activity daily rhythms such as decreased rhythm amplitude, increased fragmentation, and increased activity during the resting-sleeping phase of the day and desynchronization with the light-dark cycle. In addition, sleep deprivation successfully induces cognitive deficits in adult mouse lemurs, and the effectiveness of approved cognitive enhancers such as acetylcholinesterase inhibitors or N-methyl-D-aspartate antagonists is demonstrated in sleep–deprived animals. This result supports the translational potential of this animal model, especially for unraveling the mechanisms underlying dementia and for developing novel therapeutics to prevent age-associated cognitive decline. In conclusion, actual knowledge of BPSD/NPS-like symptoms of age-related cognitive deficits in the gray mouse lemur and the recent demonstration of the similarity of these symptoms with those seen in humans offer promising new ways of investigating both the prevention and treatment of pathological aging.

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Differences in anxiety and depression symptoms: comparison between older and younger clinical samples

Abstract: Clinicians need to assess symptoms broadly to avoid missing the presence of anxiety and mood disorders especially in older adults.

Cited by 67 publications

References 30 publications

Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

Integrated Exposure Therapy and Exercise Reduces Fear of Falling and Avoidance in Older Adults: A Randomized Pilot Study

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

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