Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins

Gouma, Sigrid; Vermeire, Tessa; Gucht, Steven Van; Martens, Lennart; Hutse, Veronik; Cremer, Jeroen; Rota, Paul A.; Leroux‐Roels, Geert; Binnendijk, Rob van; Vandermarliere, Elien

doi:10.1038/s41598-018-31630-z

Cited by 23 publications

(30 citation statements)

References 66 publications

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“…We found that there were numerous fixed differences between samples from the 2016 outbreak and the Jeryl Lynn vaccine strain in regions of immunological significance (S4A Fig and S1 Text), consistent with a recent similar analysis [27]. In the hemagglutinin-neuraminidase (HN) protein, the primary target of neutralizing antibodies [28], we observed 32 sites with fixed amino acid substitutions between our sequences and the Jeryl Lynn strain.…”

Section: Resultssupporting

confidence: 90%

Combining genomics and epidemiology to track mumps virus transmission in the United States

et al. 2020

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Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. We paired epidemiological data from public health investigations with analysis of mumps virus whole genome sequences from 201 infected individuals, focusing on Massachusetts university communities. Our analysis suggests continuous, undetected circulation of mumps locally and nationally, including multiple independent introductions into Massachusetts and into individual communities. Despite the presence of these multiple mumps virus lineages, the genomic data show that one lineage has dominated in the US since at least 2006. Widespread transmission was surprising given high vaccination rates, but we found no genetic evidence that variants arising during this outbreak contributed to vaccine escape. Viral genomic data allowed us to reconstruct mumps transmission links not evident from epidemiological data or standard single-gene

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Section: Resultssupporting

confidence: 90%

Combining genomics and epidemiology to track mumps virus transmission in the United States

et al. 2020

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“…Moreover, this virus can cause inflammation of the ovaries, testis, pancreas or meninges with several complications. After the introduction of the vaccine against measles, mumps, and rubella (MMR), mumps incidence has decreased, even if several mumps cases have recently been reported [99].…”

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confidence: 99%

Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment

Bizzoca

Campisi

Muzio

2020

IJERPH

117

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The authors performed a narrative review on Severe Acute Respiratory Syndrome- CoronaVirus-2 ( SARS-CoV-2) and all infectious agents with the primary endpoints to illustrate the most accepted models of safety protocols in dentistry and oral medicine, and to propose an easy view of the problem and a comparison (pre- vs post-COVID19) for the most common dental procedures. The outcome is forecast to help dentists to individuate for a given procedure the differences in terms of safety protocols to avoid infectious contagion (by SARS-CoV-2 and others dangerous agents). An investigation was performed on the online databases Pubmed and Scopus using a combination of free words and Medical Subject Headings (MESH) terms: “dentist” OR “oral health” AND “COVID-19” OR “SARS-CoV-2” OR “coronavirus-19”. After a brief excursus on all infectious agents transmittable at the dental chair, the authors described all the personal protective equipment (PPE) actually on the market and their indications, and on the basis of the literature, they compared (before and after COVID-19 onset) the correct safety procedures for each dental practice studied, underlining the danger of underestimating, in general, dental cross-infections. The authors have highlighted the importance of knowing exactly the risk of infections in the dental practice, and to modulate correctly the use of PPE, in order to invest adequate financial resources and to avoid exposing both the dental team and patients to preventable risks.

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“…There are been reports that the surface PRV proteins, HN and F, are the most antigenic components of other paramyxoviruses (e.g. MuV, Measles virus and PIV5) [ 18 , 20 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…reports that the surface PRV proteins, HN and F, are the most antigenic components of other paramyxoviruses (e.g. MuV, Measles virus and PIV5) [18,20,44]. Currently, several many approaches are being considered to design possible vaccines for PRV.…”

Section: Plos Onementioning

confidence: 99%

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Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus

et al. 2020

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Porcine rubulavirus (PRV), which belongs to the family Paramyxoviridae, causes blue eye disease in pigs, characterized by encephalitis and reproductive failure in newborn and adult pigs, respectively. There is no effective treatment against PRV and no information on the effectiveness of the available vaccines. Continuous outbreaks have occurred in Mexico since the early 1980s, which have caused serious economic losses to pig producers. Vaccination can be used to control this disease. Searching for effective antigen candidates against PRV, we first sequenced the PAC1 F protein, then we used various immunoinformatics tools to predict antigenic determinants of B-cells and T-cells against the two glycoproteins of the virus (HN and F proteins). Finally, we used AutoDock Vina to determine the binding energies. We obtained the F gene sequence of a PRV strain collected in the early 1990s in Mexico and compared its amino acid profile with previous and more recent strains, obtaining an identity similarity of 97.78 to 99.26%. For the F proteins, seven linear B-cell epitopes, six conformational B-cell epitopes and twenty-nine T-cell MHC class I epitopes were predicted. For the HN proteins, sixteen linear B-cell epitopes, seven conformational B-cell epitopes and thirty-four T-cell MHC class I epitopes were predicted. The ATRSETDYY and AAYTTTTCF epitopes of the HN protein might be important for neutralizing the viral infection. We determined the in silico binding energy between the predicted epitopes on the F and HN proteins and swine MHC-I molecules. The binding energy of these epitopes ranged from-5.8 to-7.8 kcal/mol. The present study aimed to assess the use of HN and F proteins as antigens, either as recombinant proteins or as a series of peptides that could activate different responses of the immune system. This may help identify relevant immunogens, saving time and costs in the development of new vaccines or diagnostic tools.

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Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins

Cited by 23 publications

References 66 publications

Combining genomics and epidemiology to track mumps virus transmission in the United States

Combining genomics and epidemiology to track mumps virus transmission in the United States

Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment

Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus

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