Differences in angiogenic potential of classically vs alternatively activated macrophages

Kodelja, Vitam; Müller, C.; Tenorio, Susanne; Schebesch, Christa; Orfanos, Constantin E.; Goerdt, Sergij

doi:10.1016/s0171-2985(97)80080-0

Cited by 179 publications

(139 citation statements)

References 53 publications

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“…A particular feature of alternatively activated macrophages consisted in the abundance of several transcripts involved in cell cycle regulation. IL-4 has been shown to induce a marginal proliferative response in murine peritoneal macrophages [24], and alternatively activated macrophages modulate proliferation in co-cultured fibroblasts and endothelial cells [31,56]. It can thus be speculated that M. tuberculosis infection modifies cell cycle functions that form part of the program induced by IL-4.…”

Section: Discussionmentioning

confidence: 99%

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

et al. 2006

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A potent Th1 immune response is critical to the control of tuberculosis. The impact of an additive Th2 response on the course of disease has so far been insufficiently characterized, despite increased morbidity after co-infection with Mycobacterium tuberculosis and Th2-eliciting helminths and possible involvement of Th2 polarization in reactivation of latent tuberculosis. Here, we describe the gene expression profile of murine bone marrow-derived macrophages alternatively activated by IL-4 in response to infection with M. tuberculosis. Comparison of transcriptional profiles of infected IL-4-and IFN-c-activated macrophages revealed delayed and partially diminished responses to intracellular bacteria in alternatively activated macrophages, characterized by reduced exposure to nitrosative stress and increased iron availability, respectively. Alternative activation of host macrophages correlated with elevated expression of the M. tuberculosis iron storage protein bacterioferritin as well as reduced expression of the mycobactin synthesis genes mbtI and mbtJ. The extracellular matrix-remodeling enzyme matrix metalloproteinase (MMP)-12 was induced in alternatively activated macrophages in vitro, and MMP-12-expressing macrophages were abundant at late, but not early, stages of tuberculosis in murine lungs. Our findings emphasize that alternative activation deprives macrophages of control mechanisms that limit mycobacterial growth in vivo, thus supporting intracellular persistence of M. tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

et al. 2006

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“…The likely source is from mast cells present in the interstitial space and known to produce IL-13 (Fijak and Meinhardt, 2006;Galli et al, 2005). Interestingly, IL-13 has been shown to induce production of TGF-β in lung macrophages in a model of pulmonary fibrosis (Lee et al, 2001), and alternatively activated macrophages produce TGF-β (Kodelja et al, 1997;Song et al, 2000). Thus, IL-13 is likely an important cytokine in the maintenance of the testicular immunosuppressed microenvironment.…”

Section: Discussionmentioning

confidence: 99%

IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages

Maresz

Ponomarev

Barteneva

et al. 2008

Journal of Reproductive Immunology

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Macrophages are thought to play an important role in the maintenance of immune privilege in the testis, which functions to prevent immune responses to developing sperm. Two populations of macrophages are known to exist in the testis, one of which exhibits immunosuppressive activity. Macrophages that are alternatively activated with either IL-4 or IL-13 have been shown to be antiinflammatory and promote wound healing. Expression of the Ym1 protein is an established marker of alternatively activated macrophages. Testicular macrophages were examined for expression of Ym1 protein, and it was found to be highly expressed in a subpopulation of CD11b + cells. Furthermore, we have shown that Ym1 protein expression in the testis is dependent upon IL-13R signaling, and that IL-13 is produced in the testis. These data suggest that IL-13 plays a role in testicular immune privilege by the maintenance of an alternatively activated macrophage population.

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“…Alternative activation of macrophages is associated with ECM production and the release of trophic factors that contribute to tissue remodelling, angiogenesis and wound healing. 47,65,66 Common alternative activation markers include expression of enzymes arginase 1 (Arg1), resistin-like molecule α (Retnla; Fizz1) and chitinase 3-like 3 (Chi3l3; Ym1). 56,67 Other stimuli shown to promote an alternative phenotype include glucocorticoids, IL-10 and immune complexes.…”

Section: Alternative Macrophage Activation and Developmentmentioning

confidence: 99%

Macrophages and CSF-1

Jones¹,

Ricardo

2013

Organogenesis

123

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Differences in angiogenic potential of classically vs alternatively activated macrophages

Cited by 179 publications

References 53 publications

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages

Macrophages and CSF-1

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