Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection

Chow, Sharon S.W.; Craig, Maria E.; Jones, Cheryl; Hall, Beverly A.; Catteau, Jacki; Lloyd, Andrew R.; Rawlinson, William D.

doi:10.1016/j.cyto.2008.06.009

Cited by 91 publications

(67 citation statements)

References 54 publications

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“…For example, interleukin 1β (IL1β) levels are known to increase at the maternal-fetal interface at the time of implantation and early placentation, 8,9 and also are increased in high sensitivity assays of normal pregnant sera at 14-16 weeks compared with known values in healthy non-pregnant controls. 10,11 It is interesting to note that several other genes in the IL1 family are differentially methylated in early pregnancy at a q value of < 0.05 in our study, also suggesting an important role of this cytokine family in maternal adaptation to pregnancy (Table S1).…”

Section: Discussionmentioning

confidence: 82%

Normal early pregnancy

et al. 2012

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Section: Discussionmentioning

confidence: 82%

Normal early pregnancy

et al. 2012

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“…A recent study by Goines et al (2011) reported elevated second trimester serum levels of IFN-γ , IL-4 and IL-5 in women who gave birth to a child subsequently diagnosed with ASD. To the best of our knowledge, this is the fi rst study to explore cytokine levels in samples of AF which is considered more representative of the foetal rather than maternal cytokine profi le (Chow et al 2008). Physiologically, pregnancy is associated with a down-regulated infl ammatory response which allows tolerance of the foetus and promotes carrying a pregnancy to term (Denney et al 2011).…”

Section: Maternal Immune Activation Cytokines and Asdmentioning

confidence: 97%

Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders

Abdallah

Larsen

Grove

et al. 2011

The World Journal of Biological Psychiatry

153

126

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“…Ainsi, la réaction inflammatoire est diffuse dans l'unité foetoplacentaire, impliquant plusieurs types cellulaires. Par contre, elle ne concerne pas le compartiment maternel, puisque, lors d'un SRIF, les concentrations sériques maternelles d'IL sont souvent basses et ne sont pas corrélées aux concentrations intra-amniotiques [14,15].…”

Section: D'où Proviennent Ces Cytokines ?unclassified

Le syndrome de réponse inflammatoire fœtale : définition, causes et conséquences

et al. 2009

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Les infections intra-utérines ou les ruptures prématurées des membranes peuvent favoriser une synthèse de cytokines pro-inflammatoires. Le terme de « syndrome de réponse inflammatoire foetale » (SRIF) est utilisé pour dénommer cette réponse immune du foetus. Plusieurs moyens permettent de reconnaître le SRIF durant la vie foetale ou à la naissance : élévation de l'interleukine (IL)-6 dans le sang du cordon, funiculite constatée à l'examen histologique du cordon ou petite taille du thymus foetal évalué par échographie. Chez le prématuré, un lien significatif entre morbidité néonatale et SRIF a été identifié, puisqu'une élévation de l'IL-6 dans le sang du cordon ou dans le liquide amniotique est constatée chez les enfants qui développeront ultérieurement une leucomalacie périventri-culaire, une dysplasie bronchopulmonaire ou une infirmité motrice cérébrale. Prévenir la morbidité néonatale liée au SRIF est un enjeu majeur en néonatologie. Dans les situations à risque, comme les ruptures prématurées des membranes, les corticoïdes en anténatal, l'antibiothérapie maternelle et l'attitude obstétricale (prolongation de la grossesse ou extraction foetale) doivent être discutés. Mots clés Interleukine · Morbidité néonatale · Inflammation foetaleAbstract Fetal inflammatory response syndrome (FIRS) is caused by stimulation of the foetal immune system and biosynthesis of pro-inflammatory cytokines in the human foetus following intra uterine infection and/or premature membrane rupture. Several diagnostic features characterise FIRS during foetal life or at birth, including elevated levels of interleukin-6 in the cord blood, histological funiculitis or small foetal thymus size measured by ultrasound. A relationship between neonatal morbidity and foetal inflammation has been demonstrated by the increased concentration of IL-6 in cord blood or amniotic fluid in children who develop periventricular leukomalacia, bronchopulmonary dysplasia or cerebral palsy. Preventing adverse neonatal outcome associated with FIRS is a real challenge for neonatology. In at risk situations, such as premature rupture of membranes, maternal glucocorticoids, antibiotic therapy and the obstetric point of view (whether to continue with the pregnancy or extract the foetus) must be discussed.

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Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection

Cited by 91 publications

References 54 publications

Normal early pregnancy

Normal early pregnancy

Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders

Le syndrome de réponse inflammatoire fœtale : définition, causes et conséquences

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