Differences in aggressive behaviour between male mice (Mus musculus L.) in colonies of different sizes

Poole, Trevor B.; Morgan, H.D.R.

doi:10.1016/s0003-3472(73)80105-8

Cited by 84 publications

(65 citation statements)

References 9 publications

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“…ATS-treated mice showed a reduction in the amount of aggression initiated and general activity relative to pretreatment levels when groups were reconstituted after treatment, and levels of activity, particularly aggression, were expected to be high (3,29), but maintained pretreatment levels of sleep. The fact that the reduction in aggression correlated with that in total IgG concentration across the period of treatment, in both ATS and naive serum control mice, strengthens the conclusion that the treatment effect was the result of increased immunodepression among ATS mice.…”

Section: Discussionmentioning

confidence: 96%

Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

Barnard

Behnke

Gage

et al. 1997

Physiology & Behavior

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. Modulation of behaviour and testosterone concentration in immunodepressed male laboratory mice (Mus musculus). PHYSIOL BEHAV 61(6) 907-917, 1997.-Recent ideas suggest that current immunocompetence may act as a constraint on behavioural and physiological decisions, where these risk imposing an additional burden on immune function. We tested this in the context of time budgeting and the secretion of the potentially immunodepressive hormones testosterone and corticosterone, by treating adult male CFLP laboratory mice with antithymocyte serum (ATS) to depress thymus-mediated immune function. In comparison with males given a naive rabbit serum (NRS) vehicle control, ATS-treated mice showed a reduction in serum testosterone concentration, aggressive behaviour, and general activity, and maintained time spent sleeping, relative to pretreatment levels. Behaviours that differed between treatments correlated with measures of immunodepression (reduction in relative thymus weight or serum total IgG concentration), but relationships with behavioural changes were independent of those with testosterone. There was little evidence that changes were affected by social status. The results are discussed in the context of the adaptive modulation of immune function and physiological and behavioural decision-making. ᭧ 1997 Elsevier Science Inc.

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Section: Discussionmentioning

confidence: 96%

Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

Barnard

Behnke

Gage

et al. 1997

Physiology & Behavior

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“…The dominant male showed more agonistic behavior probably to sustain its dominant status, while subordinate animals showed more agonistic behavior possibly to gain a higher status within the hierarchy. Indeed, Poole and Morgan [2] found that large groups of mice had a more unstable hierarchy than smaller ones and dominance status changed between animals more often. Cunningham [20], who studied hens in a similar setup to the present study, also found that in larger flocks, both the dominant and the subordinate hens showed more aggression than in smaller flocks.…”

Section: Group Size Effectsmentioning

confidence: 99%

Modulation of aggression in male mice: influence of group size and cage size

Loo

Mol

Koolhaas

et al. 2001

Physiology & Behavior

220

210

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“…However, there is a cost to social housing in aggressive animals such as male mice which fight to establish a social hierarchy (8,49,52,53). There is good evidence that the stress response produced by social stimuli is even greater than that produced by stressors such as foot-shock or food or water deprivation (34).…”

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confidence: 99%

There's no place like home: Cage odours and place preference in subordinate CD-1 male mice

Fitchett

Barnard

Cassaday

2006

Physiology & Behavior

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Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interactions between mice. We used conditioned place preference tests to investigate whether CD-1 male mice (Mus musculus) are reinforced by olfactory cues from the home cage. Soiled bedding from the home cage was presented in the initially less preferred chamber of the apparatus to determine whether this association would reduce the unconditioned preference for one chamber over the other. We tested the effects of social rank and housing condition by comparing the performance of dyads that were polarised into dominant and subordinate relationships, both when paired and when separated, with mice that were isolated throughout. The development of conditioned place preference (CPP) supported by home cage odours was influenced by social rank but not by housing condition. Only subordinate mice showed CPP to home cage odours, and this effect was seen irrespective of whether they were housed with a dominant cage mate or alone. Neither dominant (paired or separated) nor isolated mice showed any change in their preference for the chamber associated with home cage odours. This suggests that the smell of home is a more powerful reinforcer for subordinate mice in that it can produce contextual conditioning to the environment in which it is experienced. Physiology & Behavior, 87,[955][956][957][958][959][960][961][962] Laboratory rodents spend a large amount of time in their home cage environment.How do they like it? It is known that the home cage can act as an effective reinforcer for mice tested in a radial maze procedure (45). However, very few studies have investigated how mice rate the home cage environment relative to alternatives, but see (59,60).An important aspect of the home environment is whether the animal is housed singly or in a group. In their natural state, house mice (Mus domesticus) typically live in social groups (24,25,26,38,48). As would be expected, what evidence there is suggests that group housing promotes welfare in laboratories (20,61,64,65).

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Differences in aggressive behaviour between male mice (Mus musculus L.) in colonies of different sizes

Cited by 84 publications

References 9 publications

Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

Modulation of aggression in male mice: influence of group size and cage size

There's no place like home: Cage odours and place preference in subordinate CD-1 male mice

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