Differences in Adherence to Common Inhaled Medications in COPD

Huurne, Kirsten Koehorst-ter; Movig, Kris L. L.; Valk, Paul van der; Palen, Job van der; Brusse-Keizer, Marjolein

doi:10.3109/15412555.2014.995292

Cited by 21 publications

(19 citation statements)

References 23 publications

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“…Reviewing the latest literature in the field of obstructive lung diseases, adherence to therapy in asthma and COPD was a frequent subject of research [4][5][6][7][8]. The results of the present study confirm that the GINA and GOLD guidelines are the essential factors determining the specialists' choice of therapy regimen.…”

Section: Discussionsupporting

confidence: 74%

Factors affecting the choice of therapeutic regimens in asthma and chronic obstructive pulmonary disease patients and patient adherence to the therapies prescribed

Nadziakiewicz¹,

Kurek²,

Almgren-Rachtan³

et al. 2018

pdia

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Introduction: Chronic obstructive pulmonary disease (COPD) and asthma are the most common chronic respiratory diseases worldwide. At the moment, there is no information about the preferences of Polish specialists as regards the treatment of asthma and COPD or factors influencing the choice of particular treatment regimens. Aim: To determine the treatment options most commonly used by experienced pulmonologists and allergists for asthma and COPD and to identify the factors affecting the choice of a particular therapy. Material and methods: The survey included 224 doctors (pulmonologists and allergists) across Poland and concerned patients diagnosed with asthma (n = 4358) and COPD (n = 3062). Results: In the case of asthma, the most common therapy applied was inhaled glucocorticosteroids and long-acting β 2 agonists. According to 27.2% of doctors, combination therapy was used in 70-80% of patients while 23.7% declared that the proportion of patients receiving such a treatment exceeded 80%. In the case of COPD, anticholinergics were most frequently prescribed when inhaled glucocorticosteroids and long-acting β 2 agonists had proved insufficient. According to 21% of specialists, the percentage of patients treated so was 41-50%, while 19% declared the use of this treatment in 71-80% of patients. Conclusions: The most common treatments for asthma and COPD in Poland are inhaled glucocorticosteroids and long-acting β 2 agonists. The main factors influencing treatment decisions are the current GINA and GOLD recommendations as well as patients' age, comorbidities, and price of treatment.

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Section: Discussionsupporting

confidence: 74%

Factors affecting the choice of therapeutic regimens in asthma and chronic obstructive pulmonary disease patients and patient adherence to the therapies prescribed

Nadziakiewicz¹,

Kurek²,

Almgren-Rachtan³

et al. 2018

pdia

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show abstract

“…But the concept of improving adherence with the combination of drugs in one inhaler could not be supported with the COMIC data. [14] Unfortunately, not all inhaled drug substances COPD patients use are commercially available in every device, so it is not possible to study adherence without the interference of the inhalation medication delivered by the device. However, as can be seen in Table 3, there are several medications that are delivered in multiple devices in which the design of a device can explain aspects of therapy adherence.…”

Section: Discussionmentioning

confidence: 99%

“…All patients provided written informed consent. [14,15] To be eligible for the study patients had to have a clinical diagnosis of COPD, as defined by the GOLD criteria. Patients were consecutively enrolled when hospitalized for an acute exacerbation of COPD or when visiting the outpatient clinic in stable state.…”

Section: Setting and Designmentioning

confidence: 99%

The influence of type of inhalation device on adherence of COPD patients to inhaled medication

Huurne

Movig

Valk

et al. 2016

Expert Opinion on Drug Delivery

Self Cite

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Objective: To study the influence of type of inhalation device on medication adherence of COPD patients. Methods: Adherence to inhalation medication of 795 patients was recorded from pharmacy records over 3 years. It was expressed as percentage and deemed good at ≥75-≤125%, suboptimal ≥50-<75%, and poor <50% (underuse) or >125% (overuse). Since most patients used more than one device, 1379 medication periods were analyzed. Results: Patients using a Metered Dose Inhaler (MDI) or Diskus had a 2.3-fold and 2.2-fold increased risk, respectively, of suboptimal adherence versus good adherence, compared to Handihaler and a 2.1-fold and 2.2-fold increased risk, respectively, of underuse versus good adherence compared to Handihaler. Turbuhaler, MDI, Respimat had a 7.9-fold, 3.5-fold, and 2.0-fold increased risk, of overuse versus good adherence compared to Handihaler. Conclusions: In COPD, adherence to inhalation medication is device-related. Overuse was most pronounced for devices without a dose counter, devices with the ability to load a dosage without actual inhalation, or devices lacking feedback of correct inhalation. The design of the device seems to be related to underuse and overuse of inhaled medication. Future research might investigate whether prescribing a different device with similar medication improves therapy adherence. ARTICLE HISTORY

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“…Sin embargo, esta tendencia está presente en otros países (13,14) . Se suele reportar problemas con la adherencia a la medicación para pacientes con EPOC (15) , en nuestro caso encontramos un alto porcentaje de adherencia a la terapia, esto puede explicarse por el tipo de pacientes estudiados, con un gran porcentaje de disnea, o puede estar sobreestimado al ser autoreporte.…”

Section: Discussionunclassified

Características de enfermedad pulmonar obstructiva crónica por consumo de tabaco en pacientes de servicios de neumología de Lima y Callao

Guerreros

Llerena

Matsuno³

et al. 2018

Rev Peru Med Exp Salud Publica

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The aim of the study was to describe the clinical characteristics of patients with COPD receiving treatment at the pneumology units of specialized care centers in Lima and Callao. A cross-sectional study was performed on 196 patients, with a mean age of 69 years, interquartile range of 63-75 years. Of these patients, 31.1% was classified in the GOLD 1/ mild group (FEV1 ≥80%); 41.8% in the GOLD 2/moderate group (50%≤FEV1<80%); 22.5% in the GOLD 3/severe group (30%≤FEV1<50%), and 4.6% in the GOLD 4/very severe group (FEV1 <30%). A 93.9% of patients used some type of medication for COPD. The most-frequently used therapy was the combination of long-acting beta agonists and inhaled corticosteroids (LABA/ICS) (31.1%). A preliminary characterization has been obtained for COPD patients treated in these centers, but it is essential to complement these findings with longitudinal studies.

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Differences in Adherence to Common Inhaled Medications in COPD

Cited by 21 publications

References 23 publications

Factors affecting the choice of therapeutic regimens in asthma and chronic obstructive pulmonary disease patients and patient adherence to the therapies prescribed

Factors affecting the choice of therapeutic regimens in asthma and chronic obstructive pulmonary disease patients and patient adherence to the therapies prescribed

The influence of type of inhalation device on adherence of COPD patients to inhaled medication

Características de enfermedad pulmonar obstructiva crónica por consumo de tabaco en pacientes de servicios de neumología de Lima y Callao

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