Differences between target and non-target probe processing — Combined evidence from fMRI, EEG and fMRI-constrained source analysis

Galashan, Daniela; Fehr, Thorsten; Herrmann, Manfred

doi:10.1016/j.neuroimage.2015.02.044

Cited by 9 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the task was not exactly the same as that utilized by Lamp et al ( 2016 ), both research groups have suggested that the left fusiform gyrus is involved in categorical representation and verbal rehearsal. On the other hand, Galashan et al ( 2015 ) have suggested that the left fusiform gyrus may also be involved in target/non-target discrimination. Druzgal and D'Esposito ( 2001 , 2003 ) have suggested that, although mainly implicated in the processing of visual and emotional stimuli, fusiform gyrus activation may also co-occur along with DLPFC activation during working memory tasks, especially when there is an increase in working memory load.…”

Section: Discussionmentioning

confidence: 99%

Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

Wang

Cheng

et al. 2017

Front. Psychol.

View full text Add to dashboard Cite

Previous studies have suggested that patients with schizophrenia and healthy controls exhibit differential activation of and connectivity involving the dorsolateral prefrontal cortex (DLPFC) during working memory tasks, though their findings remain inconsistent. The functional integration perspective further suggests that working memory performance also modulates differences in functional interactions of the DLPFC between patients and controls. To explore this possibility, 45 healthy controls and 45 patients with schizophrenia were recruited to perform a 2-back task during functional magnetic resonance imaging (fMRI). Each group was further divided into two subgroups based on task performance to examine the modulatory effect of performance on functional interactions of the DLPFC, as measured via psychophysiological interaction (PPI) analyses. We observed that, in patients with schizophrenia who exhibited impaired working memory capacity and decreased brain activation/deactivation, functional interactions between the right/left DLPFC and angular cortex were decreased relative to those of healthy controls. Furthermore, we observed an interaction effect of working memory performance and diagnosis on functional connectivity between the right/left DLPFC seed region and posterior regions such as the angular cortex, fusiform gyrus, and middle occipital gyrus. This interaction effect was mainly driven by the negative correlation between functional connectivity and performance in healthy controls, and by the positive correlation in patients with schizophrenia. These results demonstrate the effects of inter-individual differences in working memory performance on functional interactions between the DLPFC and posterior regions in patients with schizophrenia as well as healthy controls, which may shed new light on the neural basis of working memory.

show abstract

Section: Discussionmentioning

confidence: 99%

Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

Wang

Cheng

et al. 2017

Front. Psychol.

View full text Add to dashboard Cite

show abstract

“…Second, the DMST has the advantages on dividing a process into separate stages, providing a helpful method to compare the effects of different factors. The DMST is a paradigm for studying shortterm memory, and it includes encoding, information extraction and matching, which provides a method for studying the process of memory recall (Galashan et al 2015, Gire 2020, Steffener et al 2020. Li et al used DMST to study the influence of negative emotions on spatial working memory and verbal working memory (2010).…”

Section: Introductionmentioning

confidence: 99%

A study of action difference on motor imagery based on delayed matching posture task

Zuo

Zhou

et al. 2023

J. Neural Eng.

View full text Add to dashboard Cite

Objective. Motor imagery (MI)-based brain-computer interfaces (BCI) provide an additional control pathway for people by decoding the intention of action imagination. The way people imagine greatly affects MI-BCI performance. Action itself is one of the factors that influence the way people imagine. Whether the different actions cause a difference in the MI performance is unknown. What is more important is how to manifest this action difference in the process of imagery, which has the potential to guide people to use their individualized actions to imagine more effectively. Approach. To explore action differences, this study proposes a novel paradigm named as Action Observation based Delayed Matching Posture Task (AO-DMPT). Ten subjects are required to observe, memorize, match, and imagine three types of actions (cutting, grasping and writing) given by visual images or videos, to accomplish the phases of encoding, retrieval and reinforcement of MI. Event-related potential (ERP), MI features, and classification accuracy of the left or the right hand are used to evaluate the effect of the action difference on the MI difference. Main results. Action differences cause different feature distributions, resulting in that the accuracy with high event-related (de)synchronization (ERD/ERS) is 27.75% higher than the ones with low ERD/ERS (p<0.05), which indicates that the action difference has impact on the MI difference and the BCI performance. In addition, significant differences in the ERP amplitudes exists among the three actions: the amplitude of P300-N200 potential reaches 9.28μV of grasping, 5.64μV and 5.25μV higher than the cutting and the writing, respectively (p<0.05). Significance. The ERP amplitudes derived from the supplementary motor area shows positive correlation to the MI classification accuracy, implying that the ERP might be an index of the MI performance when the people is faced with action selection. This study demonstrates that the MI difference is related to the action difference, and can be manifested by the ERP, which is important for improving MI training by selecting suitable action; the relationship between the ERP and the MI provides a novel index to find the suitable action to set up an individualized BCI and improve the performance further

show abstract

“…Functional MRI (fMRI) study provided high spatial-resolution evidence. Galashan et al ( 2015 ) combined EEG and fMRI with the same task, and they found a temporal pattern of source activities starting in occipital and temporal brain regions, followed by a simultaneous engagement of parietal and frontal brain regions and a later activity of a source in pre-supplementary motor area.…”

Section: Introductionmentioning

confidence: 99%

Retrieval Deficiency in Brain Activity of Working Memory in Amnesic Mild Cognitive Impairment Patients: A Brain Event-Related Potentials Study

Tang

Chen

2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

In the early stage of Alzheimer disease (AD) or mild cognitive impairment (MCI), working memory (WM) deficiency is prominent and could be attributed to failure in encoding, maintenance or retrieval of information. However, evidence for a retention or retrieval deficit remains equivocal. It is also unclear what cognitive mechanism in WM is impaired in MCI or early AD. We enrolled 46 subjects from our Memory Clinics and community, with 24 amnesic MCI patients and 22 normal subjects. After neurological and cognitive assessments, they performed a classic delayed match to sample (DMS) task with simultaneous event-related potential (ERP) recorded. The ERPs in encoding and retrieval epoch during WM were analyzed separately. The latency and amplitude of every ERP component were compared between two groups, and then analyzed to explore their relationship with neuropsychological performance. Finally, the locations of maximal difference in cortex were calculated by standard low-resolution tomographic analysis. A total of five components were found: P1, N1, P2, N2, and P300. The amplitude of P2 and P300 was larger in normal subjects than in MCI patients only during retrieval, not encoding epoch, while the latency did not show statistical difference. The latency and amplitude of P1 and N1 were similar in two groups. P2 amplitude in the retrieval epoch positively correlated with memory test (auditory verbal learning test) and visual spatial score of Chinese Addenbrooke's Cognitive Examination-Revised (ACE-R), while P300 amplitude correlated with ACE-R. The activation difference in P2 time range was maximal at medial frontal gyrus. However, the difference in cortex activation during P300 time range did not show significance. The amplitude of P2 indicated deficiency in memory retrieval process, potentially due to dysfunction of central executive in WM model. Regarding the location of P2 during WM task, medial frontal plays important role in memory retrieval. The findings in the present study suggested that MCI patients have retrieval deficit, probably due to central executive based on medial frontal gyrus. Thus, it may provide new biomarker for early detection and intervention for aMCI.

show abstract

Differences between target and non-target probe processing — Combined evidence from fMRI, EEG and fMRI-constrained source analysis

Cited by 9 publications

References 43 publications

Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

A study of action difference on motor imagery based on delayed matching posture task

Retrieval Deficiency in Brain Activity of Working Memory in Amnesic Mild Cognitive Impairment Patients: A Brain Event-Related Potentials Study

Contact Info

Product

Resources

About