Differences between sporadic and multiple endocrine neoplasia type 2A phaeochromocytoma

Pomares, Francisco; Cañas, R; Rodrı́guez, José Manuel; Hernández, Anixa; Parrilla, Pascual; Tébar, Francisco Javier

doi:10.1046/j.1365-2265.1998.3751208.x

Cited by 98 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic testing is recommended to every young patient with an apparently sporadic PHEO (11)(12)(13). The type of gene testing depends on the age at presentation, primary tumor location, malignancy, biochemical phenotype, and incidence (14 -16).…”

Section: Discussionmentioning

confidence: 99%

The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2

Thosani

Ayala-Ramirez

Palmer

et al. 2013

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2

Thosani

Ayala-Ramirez

Palmer

et al. 2013

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

show abstract

“…In both children and adults, the majority 10 Nonsporadic pheochromocytomas present in association with familial autosomal disorders such as familial pheochromocytoma, multiple endocrine neoplasia type 2, and von Hippel-Lindau disease (vHL). 12 Pheochromocytoma associated with vHL can often present with a normal blood pressure and normal results from urine catecholamine tests. 12 Pheochromocytoma associated with vHL can often present with a normal blood pressure and normal results from urine catecholamine tests.…”

Section: Discussionmentioning

confidence: 99%

Presenting Signs and Symptoms of Pheochromocytoma in Pediatric-aged Patients

Sullivan

Groshong

Tobias

2005

Clin Pediatr (Phila)

View full text Add to dashboard Cite

To describe the varied presenting signs and symptoms in pediatric patients with pheochromocytoma, a retrospective chart review of the presenting signs and symptoms and subsequent clinical course of patients who presented to the Pediatric ICU following surgical excision of a pheochromocytoma was undertaken. The cohort of 7 patients (5 boys, 2 girls) ranged in age from 4 to 16 years. Two patients were hypertensive at initial presentation, and the other 5 developed hypertension after their initial presentation. The initial presenting signs and symptoms were related to the central nervous system (CNS) in 6 of the patients (5 with an acute alteration in mental status and 1 with visual disturbances). Two patients presented with congestive heart failure. Other signs and symptoms at the time of initial presentation included sweating, headache, weight loss, heat intolerance, increased thirst and urination, a decline in school activity, and red/puffy hands and feet. The time from the initial presentation until the diagnosis was confirmed was 5 months or more in 4 of the 7 patients. The diagnosis was confirmed by demonstration of elevated urinary catecholamines in all 7 patients, although 2 patients had initial negative urinary levels.

show abstract

“…Urinary norepinephrine and epinephrine was assayed using the LDN CAT RIA kit (Immuno Biological Laboratories, Minneapolis, MN). The sensitivity of this method is 1.5 ng/ml for norepinephrine and 0.3 ng/ml for epinephrine; the precision is <15% for both assays (38). …”

Section: Methodsmentioning

confidence: 97%

Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men

et al. 2010

View full text Add to dashboard Cite

OBJECTIVEShort sleep duration is associated with impaired glucose tolerance and an increased risk of diabetes. The effects of sleep restriction on insulin sensitivity have not been established. This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects of a drug, modafinil, that increases alertness during wakefulness.RESEARCH DESIGN AND METHODSThis 12-day inpatient General Clinical Research Center study included 20 healthy men (age 20–35 years and BMI 20–30 kg/m2). Subjects spent 10 h/night in bed for ≥8 nights including three inpatient nights (sleep-replete condition), followed by 5 h/night in bed for 7 nights (sleep-restricted condition). Subjects received 300 mg/day modafinil or placebo during sleep restriction. Diet and activity were controlled. On the last 2 days of each condition, we assessed glucose metabolism by intravenous glucose tolerance test (IVGTT) and euglycemic-hyperinsulinemic clamp. Salivary cortisol, 24-h urinary catecholamines, and neurobehavioral performance were measured.RESULTSIVGTT-derived insulin sensitivity was reduced by (means ± SD) 20 ± 24% after sleep restriction (P = 0.001), without significant alterations in the insulin secretory response. Similarly, insulin sensitivity assessed by clamp was reduced by 11 ± 5.5% (P < 0.04) after sleep restriction. Glucose tolerance and the disposition index were reduced by sleep restriction. These outcomes were not affected by modafinil treatment. Changes in insulin sensitivity did not correlate with changes in salivary cortisol (increase of 51 ± 8% with sleep restriction, P < 0.02), urinary catecholamines, or slow wave sleep.CONCLUSIONSSleep restriction (5 h/night) for 1 week significantly reduces insulin sensitivity, raising concerns about effects of chronic insufficient sleep on disease processes associated with insulin resistance.

show abstract

Differences between sporadic and multiple endocrine neoplasia type 2A phaeochromocytoma

Abstract: In comparing sporadic and MEN 2A phaeochromocytoma we found differences in age at presentation, mode of presentation, clinical data, duration of clinical features, imaging findings bilaterality and type of surgical treatment required.

Cited by 98 publications

References 21 publications

The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2

The Characterization of Pheochromocytoma and Its Impact on Overall Survival in Multiple Endocrine Neoplasia Type 2

Presenting Signs and Symptoms of Pheochromocytoma in Pediatric-aged Patients

Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men

Contact Info

Product

Resources

About