Differences between solid and duct-ectatic types of pancreatic ductal carcinomas

Furuta, Koh; Watanabe, Hidenobu; Ikeda, Seiyo

doi:10.1002/1097-0142(19920315)69:6<1327::aid-cncr2820690605>3.0.co;2-n

Cited by 69 publications

(40 citation statements)

References 10 publications

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“…These facts raise the possibility that pancreatic cancer cells share some properties of vascular endothelial cells, rather than syncytiotrophoblasts. It might be that the pathological nature of pancreatic cancer cell growth, such as potent invasiveness (Furuta et al, 1992), has some relationship to the mode of endothelial cell growth, which also seems to invade adjacent tissues (Furcht, 1986). In this context, the characteristics of pancreatic cancer cells presented here might be useful in investigating the biology of pancreatic cancer in the future.…”

Section: Discussionmentioning

confidence: 99%

Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells

Oikawa¹,

Kushuhara²,

Ishikawa³

et al. 1994

Br J Cancer

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Summary Analysis of bioactive substances produced by cancer cells is one approach to understanding the biological features of human cancer. One of these bioactive substances is endothelin (ET)-1, a peptide with potent vasoconstrictive activity produced by vascular endothelial cells. We have previously reported the production of ET-1 by several types of human cancer, especially pancreatic cancer cells. To elucidate whether these cancer cells might share biological characteristics with vascular endothelial cells, we investigated the production of three ET isoforms in pancreatic cancer cells, using a specific radioimmunoassay. Further, we also investigated whether these cells produce thrombomodulin (TM), another product of endothelial cells functioning as a modulator of procoagulant activity. ET-1 was detected in 11 of 12 pancreatic cancer cell lines (92%) while ET-2 and ET-3 were detectable in only one cell line. Gel filtration analysis confirmed the presence of ET-1. Moreover, TM was detected in the cell lysates of 11 of the 12 cell lines (92%) and it was released into the culture medium in the majority (58%) of these cell lines. TM mRNA was also detected in these cells. In addition, TM was demonstrated immunocytochemically along the cell surface. These results suggest that pancreatic cancer cells share two characteristics with endothelial cells: the production of ET-1 and TM.

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Section: Discussionmentioning

confidence: 99%

Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells

Oikawa¹,

Kushuhara²,

Ishikawa³

et al. 1994

Br J Cancer

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“…Specimens were selected from consecutively recorded cases in our archives at the First Department of Pathology, Niigata University School of Medicine; 74 surgical cases of solid-type (invasive) carcinoma (SC) 19,20 (43 men and 31 women; mean age, 66.0 { 8.4 years; range, 49 -79 years) and 23 surgical cases of ductectatic-type (intraductal or invasive) carcinoma (DC) 19 (15 men and 8 women; mean age, 66.1 { 12.5 years; range, 43 -80 years). In addition, specimens of 24 normal pancreata (from 12 men and 12 women; mean age, 66.7 { 12.3 years; range, 39 -91 years) were collected as FIGURE 1.…”

Section: Human Pancreatic Tissuesmentioning

confidence: 99%

Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation

Matsubayashi

Watanabe

Nishikura

et al. 1998

Cancer

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having sulfo-type or sialo-type mucus. Foci from normal, DC, SC, sulfo-type, or sialo-type specimens were assessed for K-ras mutation at codon 12 by nested 1 First Department of Pathology, Niigata Univerpolymerase chain reaction and restriction fragment length polymorphism. sity School of Medicine, Niigata, Japan. RESULTS.Of the SCs, 9 were sulfo-type and 65 were sialo-type; all DC specimens 2 Department of Pathology, Tokai University were sialo-type, and all normal epithelia were sulfo-type. All foci of sulfo-type, School of Medicine, Bohseidai, Isehara, Kananonneoplastic epithelia were negative for K-ras mutation. In contrast, 124 of 313 gawa, Japan.sialo-type MCH foci (40%) had a K-ras mutation. Of 74 SCs, only 3 of 9 sulfo-type 3 Fourth Department of Internal Medicine, Tokyo tumors (33%) were positive for the mutation. Sixty of 65 sialo-type SCs (92%) had Medical College, Tokyo, Japan.a K-ras mutation, whereas 15 of 23 sialo-type DCs (65%) had a mutation. K-ras mutant carcinomas (including both SCs and DCs) were associated with K-ras mutant MCH in 109 of 198 MCHs (55%), whereas carcinomas without a K-ras mutation had mutations in 6 of 68 MCHs (9%). MCH in normal pancreata revealed K-ras mutations in 9 of 51 foci (18%). In addition, in K-ras mutant carcinomas, frequency of K-ras mutation in MCH increased from 27% (11 of 41 foci) of nonpapillary MCHs to 62% (98 of 157 foci) of papillary MCHs; but in K-ras wild-type carcinoma, the mutation rate in MCH was unchanged from 12% (3 of 26 foci) to 7% (3 of 42 foci) in nonpapillary and papillary foci, respectively. the former, whereas sialomucin is secreted by the latter. In addi- CONCLUSIONS.

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“…IPMNs mainly occur in the 6th to 7th decades of life, affecting males slightly more frequently than females. IPMNs account for 0.5% of all pancreatic neoplasms found at autopsy, 7.5% of clinically diagnosed pancreatic neoplasms, and 16.3% of surgically resected pancreatic neoplasms [20] . The IPMN was histologically defined by the WHO as "intraductal mucin-producing neoplasm with tall columnar mucin-containing epithelium with or without papillary projections, involving the MPD and/or major side branches" [21] .…”

Section: Discussionmentioning

confidence: 99%

Imaging features of intraductal papillary mucinous neoplasms of the pancreas in multi-detector row computed tomography

Tan

Ya-e²,

Wang³

et al. 2009

WJG

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AIM:To retrospectively evaluate the imaging features of pancreatic intraductal papillary mucinous neoplasms (IPMNs) in multi-detector row computed tomography (MDCT). METHODS:A total of 20 patients with pathologicallyconfirmed intraductal papillary mucinous neoplasms (IPMNs) were included in this study. Axial MDCT images combined with CT angiography (CTA) and multiplanar volume reformations (MPVR) or curved reformations (CR) were preoperatively acquired. Two radiologists (Tan L and Wang DB) reviewed all the images in consensus using an interactive picture archiving and communication system. The disputes in readings were resolved through consultation with a third experienced radiologist (Chen KM). Finally, the findings and diagnoses were compared with the pathologic results. RESULTS:The pathological study revealed 12 malignant IPMNs and eight benign IPMNs. The diameters of the cystic lesions and main pancreatic ducts (MPDs) were significantly larger in malignant IPMNs compared with those of the benign IPMNs (P < 0.05). The combinedtype IPMNs had a higher rate of malignancy than the other two types of IPMNs (P < 0.05). Tumors with mural nodules and thick septa had a significantly higher incidence of malignancy than tumors without these features (P < 0.05). Communication of side-branch IPMNs with the MPD was present in nine cases at pathologic examination. Seven of them were identified from CTA and MPVR or CR images. From comparison with the pathological diagnosis, the sensitivity, specificity, and accuracy of MDCT in characterizing the malignancy of IPMN of the pancreas were determined to be 100%, 87.5% and 95%, respectively.

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Differences between solid and duct-ectatic types of pancreatic ductal carcinomas

Cited by 69 publications

References 10 publications

Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells

Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells

Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation

Imaging features of intraductal papillary mucinous neoplasms of the pancreas in multi-detector row computed tomography

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