Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis

Li, Xianchan; Zhao, Ya‐Ning; Zhang, L.-Q.; Su, Jincang; Liu, D.-G.; Yu, Guang‐Yan

doi:10.1016/j.ijom.2021.11.003

Cited by 5 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While patients with RAI-sialadenitis were included in the patient cohort for evaluation of the COSS and MSGS questionnaires, there is a need for specific validation in this group as symptomatology may differ between patients with RAI-sialadenitis and other obstructive etiologies. 32,35,55 Further testing may improve our understanding regarding the psychometric properties of the PROMs described in this study. For instance, the evaluation of structural validity across 5/7 studies was limited to exploratory factor analysis, likely due to a lack of prior literature describing conceptual frameworks and key domains for salivary disease.…”

Section: Discussionmentioning

confidence: 97%

“…Notably, no PROMs evaluating radioactive iodine (RAI)‐induced sialadenitis met inclusion criteria. While patients with RAI‐sialadenitis were included in the patient cohort for evaluation of the COSS and MSGS questionnaires, there is a need for specific validation in this group as symptomatology may differ between patients with RAI‐sialadenitis and other obstructive etiologies 32,35,55 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Patient Reported Outcome Measures for Salivary Function: A Systematic Review

2023

View full text Add to dashboard Cite

Objective: A number of patient-reported outcome measures (PROMs) assess quality of life and symptom severity in patients with salivary gland dysfunction, but many vary in the extent of validation and domain types addressed. We identified PROMs validated to measure salivary gland function and analyzed key properties.Data Sources: PubMed, Web of Science, Embase, PsycInfo, and CINAHL. Review Methods: A systematic review was performed using Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) guidelines. Validated instruments with >1 item to assess salivary gland-related symptoms were included. PROMs were evaluated for developmental methodology, structure, validity, and reliability using Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) criteria.Results: A total of 2059 abstracts were retrieved, and 133 full-text articles were reviewed. Sixteen PROMs assessing xerostomia (n = 7), sialadenitis (n = 4), Sjogren's syndrome (n = 2), Parkinson's-associated sialorrhea (n = 2), and oral systemic sclerosis (n = 1) were identified. Most (n = 15) were developed de novo, one was adapted from a pre-existing questionnaire. Eleven PROMs demonstrated "very good" analysis of internal consistency per COSMIN criteria, and 10 included testretest data. Regarding content validity, four PROMs were developed with both patient and physician input, but none were rated as "adequate." All included comparisons against other questionnaires (n = 7), salivary flow rate (n = 9), and/or healthy controls (n = 3). The most rigorously developed PROM, the Xerostomia Inventory, was rated adequate in 6 out of 7 domains.Conclusions: Several PROMs evaluate salivary function. The abilties of these PROMs to meet design and validation standards were variable, with notable limitations in content validity for all tools. New and updated PROMs assessing obstructive and inflammatory salivary symptoms should utilize patient and provider input.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Patient Reported Outcome Measures for Salivary Function: A Systematic Review

2023

View full text Add to dashboard Cite

show abstract

“…Moreover, the clinical presentation of AP in this study, including xerostomia, parotid swelling, pain, and recurrent discomfort, mirrors symptoms observed in SS, IgG4-RD, and radioactive parotitis. 25 , 26 , 27 Consequently, clinicians must exercise discernment when evaluating middle-aged and elderly patients presenting with acute parotid swelling. Comprehensive diagnostic approaches should encompass assessments of serum total IgE, SS-specific antibodies (anti-SSA, anti-SSB, rheumatoid factor), serum IgG4 levels, and a thorough review of any prior radiotherapy to differentiate AP from these mimicking conditions effectively.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of adult patients with allergic parotitis

Gao,

Li,

et al. 2024

World Allergy Organization Journal

View full text Add to dashboard Cite

“…Radioactive iodine induced sialadenitis (RAIS) is an inflammatory lesion of the salivary gland( 20 ) that was first reported by Rigler and Scanlon ( 21 ), and was recently included in a new classification of clinical stomatology ( 22 ). Radioactive iodine induced sialadenitis have distinct imaging features in various imaging examinations ( 23 – 24 ). However, dynamic salivary gland scintigraphy is the first choice for follow-up of salivary glands after radioiodine treatment because it is functional imaging and is very sensitive to functional changes ( 19 , 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

Optimal administration time of vitamin C after 131I therapy in differentiated thyroid cancer based on propensity score matching

2022

View full text Add to dashboard Cite

ObjectivesThis study aimed to investigate the protection of the salivary glands by vitamin C administration at 2 and 24 h after an initial treatment using iodine-131 (131I) in patients with differentiated thyroid cancer (DTC) and examined the optimal administration time of vitamin C to protect the salivary glands from radiation injury.MethodThe clinical data of patients with differentiated thyroid carcinoma who had been treated with 131I in the Department of Nuclear Medicine in Shanxi Bethune Hospital from January 2014 to December 2020 were retrospectively analyzed. The propensity score matching method was adopted to match patients who received the administration of vitamin C at 2 h with those receiving administration at 24 h. A total of 230 pairs/460 patients were enrolled in the study. The chi-squared (χ2) or Fisher's exact test was used to compare the indicators representing the incidence of salivary gland injury between the two groups.ResultsThe incidence of salivary gland injury (17.39%) with acidic substances at 2 h was lower compared with administration at 24 h (26.96%). The incidence of acute salivary gland injury (15.22%) and chronic salivary gland injury (26.09%) in the 24-h group were higher than those in the 2-h group (4.78% and 18.26%, respectively). The differences in the left submandibular gland concentrate index and right submandibular gland concentrate index were statistically significant before and after treatment in both the 2 and the 24-h groups; these functions had been impaired after treatment.ConclusionsFollowing treatment with 131I, the protective effect of acidic substances administered at 2 and 24 h on the salivary glands were different. The incidence of salivary gland injury in the 2 h acid stimulation group was lower than in the 24 h acid stimulation group. The present study revealed that 131I treatment did cause some injury to the salivary glands and that the protective effect of administering vitamin C at 2 and 24 h may be limited. Accordingly, protection against salivary gland injury should be conducted using comprehensive measures.

show abstract

Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis

Cited by 5 publications

References 17 publications

Patient Reported Outcome Measures for Salivary Function: A Systematic Review

Patient Reported Outcome Measures for Salivary Function: A Systematic Review

Clinical features of adult patients with allergic parotitis

Optimal administration time of vitamin C after 131I therapy in differentiated thyroid cancer based on propensity score matching

Contact Info

Product

Resources

About