Differences Between Patients with and without Atherosclerosis in Expression Levels of Inflammatory Mediators in the Adipose Tissue Around the Coronary Artery

Suzuki, Tomoaki; Ogita, Hisakazu; Sato, Akira; Minamidate, Naoshi; Hachiro, Kohei

doi:10.1536/ihj.20-585

Cited by 8 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Especially statins have been shown to reduce the volume of EAT [ 35 ]. In a recent smaller study, IL-1β and IL-6 were found higher expressed in pericoronary artery adipose tissue, probably comparable with the EAT in our study, in patients with atherosclerotic heart disease compared to controls with mitral valve surgery [ 36 ]. This CAD population consisted of a large proportion with diabetes and hypertension, which may explain the difference.…”

Section: Discussionsupporting

confidence: 87%

The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery

Åkra

Seljeflot

Braathen

et al. 2022

Atherosclerosis Plus

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery

Åkra

Seljeflot

Braathen

et al. 2022

Atherosclerosis Plus

View full text Add to dashboard Cite

“…In obesity-related hypertension, there is clear evidence of an imbalance of the systems regulating blood pressure behavior and chronic low-grade inflammation, favoring decreased insulin sensitivity ( 27 , 28 ). Moreover, the obesity is characterized by higher oxidative stress behavior, contributing to the development of cardiovascular and metabolic comorbidities; in particular, several studies have found the activation of the main physiological source of reactive oxygen species production, NADPH oxidase (in particular the NOX2 catalytic subunit), favoring the alteration of nitric oxide synthase (NOS) activity and consequent endothelial dysfunction and cardiovascular organ damage ( 29 ). Chronic inflammation induces inadequate perfusion with consequent local hypoxia, mainly mediated by HIF-1α (hypoxia-inducible factor alpha), which represents a link with an increased production of inflammatory cytokines ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Relevance of obesity-related organ damage and metabolic syndrome classification in cardiovascular and renal risk stratification in patients with essential hypertension

Petramala,

Gigante,

Sarlo

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

IntroductionHypertension is a relevant cardiovascular comorbidity. Adipose tissue represents a metabolically active tissue involved in the regulation of blood pressure and metabolic alterations. In recent decades, several classifications for the metabolic syndrome (MS) have been proposed. Recently, a new syndrome called the “Cardiovascular-kidney-metabolic” (CKM) syndrome was identified, to determine patients at high cardiovascular and metabolic risk. The aim of the study was to compare different classifications in a large population of hypertensive patients.Materials and methodsBetween September 2022 and August 2023, we consecutively enrolled 772 hypertensive patients (407 men; 365 women; mean age 52.2 ± 15.1 years), evaluating anthropometric, biochemical, and instrumental parameters (transthoracic echocardiogram, carotid echo-Doppler, 24-h ambulatory blood pressure monitoring, fundus oculi).ResultsUsing different classifications we found MS prevalence: Adult Treatment Panel III (ATP-III) 28.8%, International Diabetes Federation (IDF) 31.5%, CKM 40.7%. CKM Classes 3 and 4 showed higher body mass index and waist circumference compared with other groups. Compared with ATP-III and IDF, CKM Class 4 showed higher 24-h systolic blood pressure, lower percentage of controlled hypertension, increased interventricular septum and posterior wall, reduced ejection fraction, and greater prevalence of hypertensive arterial retinal damage.DiscussionVisceral obesity and MS are frequent conditions with healthy impact, becoming an important trigger for the development of cardiovascular and metabolic complications. The different MS classifications allow the early identification of patients at high risk of cardiometabolic complications. The new CKM syndrome proves useful to identify individuals at high risk for CKM morbidity and mortality.

show abstract

“…27,28 In addition, PCAT in patients with coronary heart disease show very highly elevated levels of expression of inflammatory mediators in relation to those without CAD. 29 Coronary perivascular adipocytes have the potential to significantly modulate vascular inflammatory crosstalk in the setting of atherosclerosis, given their ability to signal to both endothelial and inflammatory cells. 30 miRs act as messengers for intercellular communication and play important roles in modulating the occurrence and progression of atherosclerosis and acute coronary syndrome.…”

Section: Discussionmentioning

confidence: 99%

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

et al. 2022

View full text Add to dashboard Cite

Pericoronary adipose tissue (PCAT) is a source of microRNAs (miRs) that act as messengers for intercellular communication. We investigated whether the PCAT surrounding significant coronary atherosclerotic lesions shows specific miR expression patterns compared with PCAT surrounding plaque-free segments. We included 49 patients with 3-vessel coronary artery disease (CAD) and 19 patients with severe valvular disease but no CAD, who underwent elective cardiac surgery. The PCAT was harvested from two sites: adjacent to a significant atherosclerotic coronary lesion and from plaque-free segments. miR-133a, miR-21, miR-26b, miR-9, and miR-143 levels in PCAT cells were quantified by real-time reverse transcription polymerase chain reaction (data expressed as arbitrary units). Expression of miR-133, miR-21, and miR-26b in adipose tissue at a site without atherosclerotic lesion was much lower in patients with CAD than in those without CAD (0.82 ± 1.37 vs 1.86 ± 0.52, P < .001, 0.45 ± 1.3 vs 1.51 ± 1.11, P < .001, 0.3 ± 1.25 vs 1.2 ± 0.73, P = .02, respectively). In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 ± 0.96 vs 0.82 ± 0.37 (P = .011), 0.91 ± 1.7 vs 0.3 ± 1.25 (P = .012), 1.2 ± 1.59 vs 0.43 ± 0.54 (P < .001), respectively). Our findings open new perspectives for the role of PCAT in the pathophysiology of atherosclerosis and should be further investigated.

show abstract

Differences Between Patients with and without Atherosclerosis in Expression Levels of Inflammatory Mediators in the Adipose Tissue Around the Coronary Artery

Cited by 8 publications

References 20 publications

The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery

The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery

Relevance of obesity-related organ damage and metabolic syndrome classification in cardiovascular and renal risk stratification in patients with essential hypertension

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

Contact Info

Product

Resources

About