Differences between nitrates: role of isosorbide 2-mononitrate

Raddino, Riccardo; Caretta, Giorgio; Bonadei, Ivano; Teli, Melissa; Vizzardi, Enrico; Dei, Livio

doi:10.2459/jcm.0b013e328335fb8c

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Isosorbide nitrates include isosorbide dinitrate (IS-DN), 2-mononitrate (IS-2-MN), and 5-mononitrate (IS-5-MN), the last two being active metabolites of IS-DN and they exert qualitatively similar effects. A comparative study on these compounds reveals that IS-2-MN induces a lower increase of cyclic guanosine monophosphate (cGMP) and less tolerance induction, and its vasodilator effect is probably due to other mechanisms than the stimulation of guanylate cyclase (Raddino et al, 2010 ). U. Thadani and T. Rodgers reported a series of problems due to the administration of isosorbide nitrates: 82% of patients accused headaches and ~10% could not tolerate them due to dizziness and/or disabling headaches; severe hypotension cases accompanied by syncope were recorded; the combination of nitrates and phosphodiesterase-5 inhibitors used together for the treatment of erectile dysfunction induces a major decrease of blood tension and might lead to death (Thadani and Rodgers, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

et al. 2020

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Due to their effect of vasodilatation, isosorbide nitrates represent one of the most important and most used solutions for angina pectoris. Unfortunately, these compounds have multiple dose-related adverse drug reactions such as headache, weakness, mild dizziness, and occasionally heart rate changes, nausea, vomiting, and sweating. The main aims of this research were to obtain and to evaluate new polyurethane (PU) structures that can be used as a proper transmembrane carrier with an improved release kinetic. Chitosan-based PU structures were obtained by a polyaddition process between hexamethylene diisocyanate and a mixture of chitosan, butanediol, and polyethylene glycol in the presence of caffeine as a synthesis catalyst. The obtained samples (with and without isosorbide nitrates) were characterized regarding the encapsulation and release rate (UV-Vis spectra), chemical composition (FTIR), thermal stability (thermal analysis), morphology changes (SEM and SANS), and in vivo irritation tests. These methods revealed no significant differences between the two sample structures. Multipopulational structures with sizes between 73 and 310 nm, with an increased tendency to form clusters and a high resistance to heat (up to 280 • C), were obtained. This study presents an alternative administration of isosorbide derivatives based on a PU carrier with a high biocompatibility and a prolonged release.

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Section: Introductionmentioning

confidence: 99%

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

et al. 2020

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Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma

Patel

Pulakundam²,

Gadekar³

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Kenawy,

Abd El.Hay,

Saad

et al. 2024

Sci Rep

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Poly l(+) lactic acid (PLLA) has become crucial in the biomedical industry for various uses. The direct polycondensation method was used to prepare Poly l(+) Lactic Acid (PLLA). Different catalysts, including metal oxides and metal halides, were used to test the polymerization technique. The effect of the amount of catalysts and the type of coupling agent were investigated. The effect of reaction time and polymerization solvents was also studied. PLLA was loaded with isosorbide dinitrate utilizing the solvent evaporation process. The synthesized polymer-drug system was evaluated by different means such as FT-IR, TGA, DSC, XRD, entrapment efficiency (E.E), drug loading (D.L), particle size analysis, and zeta potential determination. Studies on in-vitro release using UV light at 227 nm at various pH levels were conducted, and the kinetics of release and cytotoxicity using the sulforhodamine B (SRB) assay on human skin fibroblast cells were examined.

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Differences between nitrates: role of isosorbide 2-mononitrate

Abstract: These data suggest that 2MN is able to induce a lower cGMP increase and less tolerance induction; since these observations seem to be correlated, the vasodilator effect of 2MN probably also involves mechanisms other than stimulation of guanylate cyclase.

Cited by 5 publications

References 25 publications

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

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