Differences between electrically evoked compound action potential (ECAP) and behavioral measures in children with cochlear implants operated in the school age vs. operated in the first years of life

Vlahović, Sanja; Šindija, Branka; Aras, Ivana; Glunčić, Matko; Trotić, Robert

doi:10.1016/j.ijporl.2012.02.037

Cited by 11 publications

(6 citation statements)

References 63 publications

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“…Previous studies have failed in their attempts to correlate speech perception thresholds with most of the electrophysiological measurements performed with a CI [ 20 , 21 ]. Indeed, speech perception not only relies on the efficacy of the electrical stimulation, but also involves central auditory pathways in addition to brain language areas and networks [ 1 – 3 ].…”

Section: Discussionmentioning

confidence: 99%

Modeling of Auditory Neuron Response Thresholds with Cochlear Implants

Venail

Mura

Akkari

et al. 2015

BioMed Research International

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The quality of the prosthetic-neural interface is a critical point for cochlear implant efficiency. It depends not only on technical and anatomical factors such as electrode position into the cochlea (depth and scalar placement), electrode impedance, and distance between the electrode and the stimulated auditory neurons, but also on the number of functional auditory neurons. The efficiency of electrical stimulation can be assessed by the measurement of e-CAP in cochlear implant users. In the present study, we modeled the activation of auditory neurons in cochlear implant recipients (nucleus device). The electrical response, measured using auto-NRT (neural responses telemetry) algorithm, has been analyzed using multivariate regression with cubic splines in order to take into account the variations of insertion depth of electrodes amongst subjects as well as the other technical and anatomical factors listed above. NRT thresholds depend on the electrode squared impedance (β = −0.11 ± 0.02, P < 0.01), the scalar placement of the electrodes (β = −8.50 ± 1.97, P < 0.01), and the depth of insertion calculated as the characteristic frequency of auditory neurons (CNF). Distribution of NRT residues according to CNF could provide a proxy of auditory neurons functioning in implanted cochleas.

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Section: Discussionmentioning

confidence: 99%

Modeling of Auditory Neuron Response Thresholds with Cochlear Implants

Venail

Mura

Akkari

et al. 2015

BioMed Research International

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“…Gordon et al, 23 Hughles et al 6 and Vlahovic et al 21 also found higher amplitude of ECAP in the apical electrodes than in the medial and basal electrodes. These results suggest that electrical stimulation of the basal electrodes may involve a smaller number of spiral ganglion cells, when compared to stimulation in the intermediate or apical electrodes.…”

Section: Discussionmentioning

confidence: 91%

“…Considering the literature findings correlated to the present study data, we can assume that chronic stimulation of the low-frequency cochlear region during the preoperative period may have contributed to improve neuronal survival and/or improve neuronal synchrony of peripheral neurons in the apical portion of the cochlea, or that performing hearing rehabilitation preoperatively, and the activation and development of the central auditory pathways contribute to the functional maintenance of spiral ganglion cells in the apical portion of the cochlea. 21 …”

Section: Discussionmentioning

confidence: 99%

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Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants

Caldas

Cardoso

Barreto

et al. 2016

Brazilian Journal of Otorhinolaryngology

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“…Numerous researchers reported weak to moderate correlations between the ECAP thresholds and the behavioral T/C levels; however, the contribution of the ECAP thresholds for explaining the fitting maps (MAPs) remains unconvincing. [1][2][3][4] The analogical role of impedances was not observed previously. 5,6 This study has been undertaken to evaluate the possible correlation between the subjective parameters of the fitting maps such as T/C levels and the impedance of the electrode contacts.…”

mentioning

confidence: 99%

Prediction of Behavioral T/C Levels in Cochlear Implant Patients Based Upon Analysis of Electrode Impedances

Zarowski

Molisz²,

Cardinael³

et al. 2020

J Am Acad Audiol

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Background Fitting cochlear implants in babies and noncooperative patients is cumbersome and time consuming. Therefore, objective parameters have been sought in order to predict the subjective threshold (T) and maximum comfort (C) levels. Measurements of the electrically evoked compound action potentials (ECAPs) have been widely used for this purpose, yet the correlation between these objective measures and the subjective T/C levels is weak to moderate. Purpose This article aims (1) to evaluate correlations between the subjective parameters of the fitting maps such as thresholds (T level) and maximum comfort levels (C level), the impedance of the electrode contacts, and the ECAP thresholds, and (2) to compare the value of the electrode impedances and the ECAP measures for prediction of the T/C levels. Research Design Case review study in a quaternary otologic referral center. Study Sample Ninety-eight consecutive CI patients were enrolled. The average age of the patients was 49 years. All patients were users of the Nucleus 24RECA (Freedom, Contour Advance-of-Stylet electrode) cochlear implant. Data Collection and Analysis Data on impedance of the electrode contacts and the behavioral T/C levels at the first fitting session (2–5 weeks after surgery) and at the 5th fitting session (4–6 months after surgery) have been retrospectively collected in 98 consecutive CI patients. Additionally, the intraoperative impedance values and the ECAP thresholds (tNRT) have been recorded. Results Impedances of electrode contacts show significant strong negative correlations with the stabilized T/C levels at 4 to 6 months after implantation and are an important predictor for the behavioral T/C levels. They can explain R 2 = 28 to 41% of the variability of the behavioral T/C levels. In multiple regression analysis electrode contact impedances can explain twice as much of the variability of the stabilized T/C levels than the tNRT values. The electrode impedances together with the tNRT values are able to explain R 2 = 37 to 40% of the global variability of the T/C levels while the tNRT thresholds solely are able to explain only R 2 = 5 to 14% of the T/C levels variability. Conclusion Impedances of electrode contacts correlate strongly with the stabilized behavioral T/C levels and may be used as an objective measure for fitting of cochlear implants.

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Differences between electrically evoked compound action potential (ECAP) and behavioral measures in children with cochlear implants operated in the school age vs. operated in the first years of life

Cited by 11 publications

References 63 publications

Modeling of Auditory Neuron Response Thresholds with Cochlear Implants

Modeling of Auditory Neuron Response Thresholds with Cochlear Implants

Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants

Prediction of Behavioral T/C Levels in Cochlear Implant Patients Based Upon Analysis of Electrode Impedances

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