Differences between clinical and laboratory findings in patients with recent diagnosis of SLE according to the positivity of anti-dsDNA by the <i>Crithidia luciliae</i> method

Sârbu, Mihaela Ionela; Salman-Monte, Tarek Carlos; Muñoz, Pilar; Bernabé, Miriam Almirall; Carbonell, J.

doi:10.1177/0961203315573852

Cited by 13 publications

(9 citation statements)

References 14 publications

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“…The anti-dsDNA level inversely correlated with TLC. Patients positive for anti-dsDNA had significantly higher lymphopenia 17 and anti-dsDNA antibodies correlated with leucopenia. 18…”

Section: Discussionmentioning

confidence: 94%

“…The anti-dsDNA level was significantly increased in those with musculoskeletal manifestations. Patients positive for anti-dsDNA presented significantly more musculoskeletal symptoms at baseline 17 and the anti-dsDNA antibodies correlated with arthritis. 18 In agreement, the presence of antibodies against dsDNA may define a subset of SLE patients suffering from arthritis.…”

Section: Discussionmentioning

confidence: 96%

“…Patients positive for anti-dsDNA had significantly higher aCL antibodies. 17 SLE is characterized by the presence of aPL and anti-dsDNA autoantibodies in the sera of patients. These autoantibodies and their subclasses have received increasing attention by the medical community due to their association with recurrent venous thrombosis, fetal loss and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

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Anti-dsDNA titre in female systemic lupus erythematosus patients: relation to disease manifestations, damage and antiphospholipid antibodies

Gheita

Abaza

Hammam

et al. 2018

Lupus

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Background Attempts are ongoing to unveil unresolved queries about anti-double-stranded deoxyribonucleic acid (anti-dsDNA), their precise pathogenic effects and to what extent blocking them would be a useful therapeutic goal. Objectives The aim of the present study was to determine the anti-dsDNA antibodies titre in systemic lupus erythematosus (SLE) patients and investigate their relation to the disease characteristics, activity, damage and antiphospholipid autoantibodies (aPL). Methods Seventy female SLE patients and 35 age- and sex-matched controls were included. The anti-dsDNA level and aPL were measured. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI) were assessed. Results The mean age of the patients was 27.5 ± 5.1 years, disease duration 7.7 ± 5.4 years, and SLEDAI and SLICC/ACR-DI scores were 6.8 ± 8.04 and 1.2 ± 1.3, respectively. Anti-dsDNA was positive in 61.4% of the patients and the titre (133.2 ± 100.5 IU/ml) was significantly higher compared to controls (22.03 ± 17.2 IU/ml) ( p < 0.0001). The anti-dsDNA level was significantly increased in those with musculoskeletal manifestations ( p = 0.007) and positive anti-β2 glycoprotein (anti-β2GP) ( p = 0.037) and decreased in those with neuropsychiatric manifestations ( p = 0.004) and those receiving cyclophosphamide (CYC) ( p = 0.013). The anti-dsDNA level tended to be higher in active patients. The anti-dsDNA titre significantly correlated with the erythrocyte sedimentation rate ( p = 0.001), anticardiolipin IgG and IgA antibodies ( p = 0.008) and anti-β2GP IgG ( p = 0.03) and IgA ( p = 0.002) and inversely with the total leucocytic count ( p < 0.0001) and SLICC/ACR-DI ( p = 0.001). Conclusion Anti-dsDNA is remarkably increased in SLE patients especially those with musculoskeletal manifestations and aPL. A protective role seems likely in those with neuropsychiatric manifestations and those receiving CYC and may form a shield against disease tissue damage.

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“…The anti-dsDNA level inversely correlated with TLC. Patients positive for anti-dsDNA had significantly higher lymphopenia 17 and anti-dsDNA antibodies correlated with leucopenia. 18…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-dsDNA titre in female systemic lupus erythematosus patients: relation to disease manifestations, damage and antiphospholipid antibodies

Gheita

Abaza

Hammam

et al. 2018

Lupus

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“…The 64 eligible studies comprised 66 cohorts with a total of 13,080 SLE patients, of whom 12,542 (95.9%) were reported to be IIF‐ANA positive at various titers (range 76% to 100% calculated sensitivity, see Table ). A total of 7,539 subjects were included as a control population.…”

Section: Resultsmentioning

confidence: 99%

Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta‐Regression of Diagnostic Data

Leuchten

Hoyer

Brinks³

et al. 2018

Arthritis Care & Research

138

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“…The pathogenesis of WM hyperintensity is attributed to chronic small vessel disease, which is supported by a study with radiologic-pathologic correlation in patients with neurolupus (Sibbitt et al, 2010 ). The underlying mechanisms for small vessel disease in neurolupus are not well understood, although multiple factors are incriminated, including accelerated atherosclerosis, direct immune mediated alterations, microembolisms, intimal hyperplasia, erythrocytes extravasation, fibrin thrombi, and coagulopathy (Joseph and Scolding, 2009 ; Sarbu et al, 2015a , c ).…”

Section: Discussionmentioning

confidence: 99%

Automated Detection of Lupus White Matter Lesions in MRI

Roura

Sârbu

Oliver

et al. 2016

Front. Neuroinform.

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Brain magnetic resonance imaging provides detailed information which can be used to detect and segment white matter lesions (WML). In this work we propose an approach to automatically segment WML in Lupus patients by using T1w and fluid-attenuated inversion recovery (FLAIR) images. Lupus WML appear as small focal abnormal tissue observed as hyperintensities in the FLAIR images. The quantification of these WML is a key factor for the stratification of lupus patients and therefore both lesion detection and segmentation play an important role. In our approach, the T1w image is first used to classify the three main tissues of the brain, white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF), while the FLAIR image is then used to detect focal WML as outliers of its GM intensity distribution. A set of post-processing steps based on lesion size, tissue neighborhood, and location are used to refine the lesion candidates. The proposal is evaluated on 20 patients, presenting qualitative, and quantitative results in terms of precision and sensitivity of lesion detection [True Positive Rate (62%) and Positive Prediction Value (80%), respectively] as well as segmentation accuracy [Dice Similarity Coefficient (72%)]. Obtained results illustrate the validity of the approach to automatically detect and segment lupus lesions. Besides, our approach is publicly available as a SPM8/12 toolbox extension with a simple parameter configuration.

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Differences between clinical and laboratory findings in patients with recent diagnosis of SLE according to the positivity of anti-dsDNA by the Crithidia luciliae method

Abstract: The presence of anti-dsDNA by the CLIF method in newly diagnosed SLE was associated with certain markers of increased disease activity. Its use could be a useful biomarker for a specific clinical phenotype suggestive of a more severe involvement at the time of the diagnosis.

Cited by 13 publications

References 14 publications

Anti-dsDNA titre in female systemic lupus erythematosus patients: relation to disease manifestations, damage and antiphospholipid antibodies

Anti-dsDNA titre in female systemic lupus erythematosus patients: relation to disease manifestations, damage and antiphospholipid antibodies

Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta‐Regression of Diagnostic Data

Automated Detection of Lupus White Matter Lesions in MRI

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