Differences between cerebral and cerebellar autoregulation during progressive hypotension in rats

Merzeau, Sandra; Preckel, Marie-Pierre; Fromy, Bérengère; Lefthériotis, Georges; Saumet, J. L.

doi:10.1016/s0304-3940(00)00763-1

Cited by 10 publications

(13 citation statements)

References 12 publications

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“…With the help of the LCT several pathological conditions affecting CA have been investigated [7, 8, 9, 10]. Orthostatic dysregulation is explained by an insufficient blood supply to the brain that can be diagnosed by the LCT [11, 13, 18, 19]. Whereas a decrease in ABP pressure leads to a decrease in ABP in the whole brain, most presyncopal clinical symptoms could be related functional-anatomically to the vascular territory of the vertebrobasilar system [12, 13].…”

Section: Discussionmentioning

confidence: 99%

“…Whereas a decrease in ABP pressure leads to a decrease in ABP in the whole brain, most presyncopal clinical symptoms could be related functional-anatomically to the vascular territory of the vertebrobasilar system [12, 13]. Together with the finding of different CA in the cortex and cerebellum in animal experiments the question arises whether CA differ in carotid and vertebrobasilar vascular systems [17, 18]. But it is difficult to compare CA in such anatomically different neuronal structures such as the cortex and cerebellum.…”

Section: Discussionmentioning

confidence: 99%

“…Because all TCD investigations in this field were performed for the middle cerebral artery (MCA) they could not detect differences of CA in the territory of the carotid versus the vertebrobasilar vascular system [4, 7, 9, 15, 16]. It has been suggested from animal studies that CA of the cortex differs from that in the cerebellum [17, 18]. We compared time courses of CBF regulation due to an ABP step insonating the MCA and posterior cerebral artery (PCA) in healthy young volunteers.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Autoregulation in Middle Cerebral Artery Territory Precedes That of Posterior Cerebral Artery in Human Cortex

Rosengarten

Kaps²

2002

Cerebrovasc Dis

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Objective: Cerebral autoregulation tends to compensate changes in arterial blood pressure. This mechanism of cerebral blood flow regulation appears to be insufficient in orthostatic dysregulation in which mainly vertebrobasilar symptoms occur. To investigate this hypothesis, we compared cerebral autoregulation in the vascular territory of the carotic and vertebrobasilar vessel system using a leg cuff test to induce a drop in cerebral perfusion pressure. Methods: We measured blood flow velocity in 10 healthy young volunteers (aged 26.7 ± 0.3 years, 7 male) simultaneously in the middle and posterior cerebral artery with transcranial Doppler sonography. A leg cuff test was used to induce a sudden decrease in arterial blood pressure. Arterial blood pressure was measured with a non-invasive photoplethysmographic method. The averaged relative blood flow velocity changes due to the pressure step were compared between both vessel territories. Results: After cuff release systolic (diastolic) blood flow velocity increased with a latency of 1.1 ± 0.3 s (1.8 ± 0.4 s). Due to a smaller decrease and identical time courses cerebral blood flow velocity recovery in the posterior cerebral artery precedes blood flow recovery in the middle cerebral artery by 0.9 ± 0.3 s. Discussion: Cerebral autoregulation in the carotid and vertebrobasilar system does not differ in the time course of the blood flow velocity recovery. Due to a smaller decrease in blood flow velocity recovery in the posterior cerebral artery precedes recovery in the middle cerebral artery by nearly 1 s.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral Autoregulation in Middle Cerebral Artery Territory Precedes That of Posterior Cerebral Artery in Human Cortex

Rosengarten

Kaps²

2002

Cerebrovasc Dis

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“…Systemic CO 2 and MABP changes superimposed upon permanent PCA occlusion in dogs showed graded autoregulatory decompensation caudally from the supratentorium to the brainstem, while the MCA autoregulation was preserved [33]. Experimental work in rats showed cerebral sparing when systemic hypotension led to progressive declines of cerebellar autoregulatory kinetics while MCA autoregulatory kinetics remain intact [34]. Cerebellar autoregulatory impairment also occurred after bilateral carotid ligation in spontaneously hypertensive rats [35].…”

Section: Pathophysiology: Vascular Responsesmentioning

confidence: 99%

“…In comparison, the addition of hypocapnia to systemic hypotension in cats, led to greater ischemic susceptibility in the MCA-region compared to the cerebellum [36]. Therefore cerebellar autoregulatory kinetics may handle CO 2 changes more favorably in the face of hypoperfusion, while a drop in MABP without systemic CO 2 changes would affect the cerebellum more severely [34]. …”

Section: Pathophysiology: Vascular Responsesmentioning

confidence: 99%

Infratentorial Strokes for Posterior Circulation Folks: Clinical Correlations for Current Translational Therapeutics

Lekic

Krafft

Coats

et al. 2011

Transl. Stroke Res.

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Approximately 20 percent of all strokes will occur in the Infratentorial brain. This is within the vascular territory of the posterior vascular circulation. Very few clinical specifics are known about the therapeutic needs of this patient sub-population. Most evidence-based practices are founded from research about the treatment of anterior circulatory stroke. As a consequence, little is known about how stroke in the Infratentorial brain region would require a different approach. We characterized the neurovascular features of Infratentorial stroke, pathophysiological responses, and experimental models for further translational study.

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What is the optimal anesthetic protocol for measurements of cerebral autoregulation in spontaneously breathing mice?

et al. 2010

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Autoregulation, an important feature of the cerebral circulation, is affected in many diseases. Since genetically modified mice are a fundamental tool in biomedical research, including neuro(bio)logy also in this specie measurements of cerebral autoregulation (CA) are mandatory. However, this requires anesthesia that unfortunately significantly impacts cerebral perfusion and consequently might distort CA measurements directly or by altering arterial pCO(2). The latter can be avoided by artificial ventilation but requires several control measurements of blood gases, each consuming at least 100 μl of blood or 5% of a mouse's blood volume. To avoid such diagnostic hemorrhage, we systematically analyzed the effect of different common anesthetic protocols used for rodents in spontaneously breathing mice on CA measured with Laser speckle perfusion imaging. Halothane, Isoflurane and Pentobarbital abrogated CA and Ketamin/Xylazine as well as Chloralose had a moderate reproducibility. In contrast, the rather rarely used anesthetic Ethomidate applied in low doses combined with local anesthetics had the best reproducibility. Although with this anesthesia the lower CA limit was lower than with Ketamin/Xylazine and Chloralose as reported in the handful of papers so far dealing with CA in mice, we suggest Ethomidate as the anesthetic of choice for CA measurements in spontaneously breathing mice.

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Differences between cerebral and cerebellar autoregulation during progressive hypotension in rats

Cited by 10 publications

References 12 publications

Cerebral Autoregulation in Middle Cerebral Artery Territory Precedes That of Posterior Cerebral Artery in Human Cortex

Cerebral Autoregulation in Middle Cerebral Artery Territory Precedes That of Posterior Cerebral Artery in Human Cortex

Infratentorial Strokes for Posterior Circulation Folks: Clinical Correlations for Current Translational Therapeutics

What is the optimal anesthetic protocol for measurements of cerebral autoregulation in spontaneously breathing mice?

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