Differences between brain responses to peroneal electrical transcutaneous neuromodulation and transcutaneous tibial nerve stimulation, two treatments for overactive bladder

Abstract

Objectives: To compare brain responses to peroneal electrical transcutaneous neuromodulation (peroneal eTNM®) and transcutaneous tibial nerve stimulation (TTNS), two methods for treating overactive bladder (OAB), using functional magnetic resonance imaging (fMRI). The present study was not designed to compare their clinical efficacy. Materials and Methods: This study included 32 healthy adult female volunteers (average age 38.3 years (range 22−73)). Brain MRI using 3 T scanner was performed during three 8-min blocks of alternating sequences.During each 8-min block, the protocol alternated between sham stimulation (30 s) and rest (30 s) for 8 repeats; then peroneal eTNM® stimulation (30 s) and rest (30 s) for 8 repeats; then, TTNS stimulation (30 s) and rest (30 s) for 8 repeats. Statistical analysis was performed at the individual level with a threshold of p = 0.05, family-wise error (FWE)-corrected. The resulting individual statistical maps were analyzed in group statistics using a onesample t-test, p = 0.05 threshold, false discovery rate (FDR)-corrected.Results: During peroneal eTNM®, TTNS, and sham stimulations, we recorded activation in the brainstem, bilateral posterior insula, bilateral precentral gyrus, bilateral postcentral gyrus, left transverse temporal gyrus, and right supramarginal gyrus. During both peroneal eTNM® and TTNS stimulations,

Optimization of electrical stimulation/modulation therapies in the management of neurogenic and non-neurogenic lower urinary tract dysfunction

“…a. Tibial neurostimulation and the activity of brain structures Krhut et al(143) evaluated acute changes in brain activity in response to different types of electrical stimulation, including tibial stimulation, peroneal stimulation, and "sham" stimulation. For this study, 32 "healthy" women were included, and brain fMRI (3 Tesla) was performed comprising three 8-minute blocks of alternating sequences.…”