Differences between asthma in young and elderly: Results from the COREA study

Park, Heung-Woo; Kwon, Hyouk‐Soo; Kim, Tae‐Bum; Kim, Sang‐Heon; Chang, Yoon-Seok; Jang, An‐Soo; Cho, You-Sook; Nahm, Dong-Ho; Park, Jung-Won; Yoon, Haesang; Cho, Young-Joo; Choi, Byoung Whui; Moon, Hee‐Bom; Cho, Sang Heon

doi:10.1016/j.rmed.2013.07.016

Cited by 18 publications

(13 citation statements)

References 24 publications

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“…For many years asthma in the older adult had been considered non-atopic [ 9 ], but recent studies show that it is also atopic, with percentages of allergies ranging from 30 to 77% [ 7 , 8 , 10 , 11 ]. In addition, a recent study performed in the United States with a large population of patients, reported a percentage of allergies of approximately 65% in elderly asthmatics, which is similar to that observed in young asthmatic patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and comorbidities of elderly asthmatics who attend allergy clinics

Yáñez¹,

Soria²,

Barayazarra

et al. 2018

asthma res and pract

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BackgroundTo date, few studies have focused on the clinical and allergic characteristics of asthma in the elderly, defined as asthma in people aged 60 or over. Thus, we propose to identify and study the clinical and allergic characteristics and comorbidities of patients with asthma among the elderly.MethodsA retrospective, observational, descriptive study was developed in five clinics and hospitals in Argentina. Allergy Physicians analyzed their patients’ medical records in 2014 and included those adults over the age of 60, who had been diagnosed with asthma according to the GINA guidelines. Clinical and allergic characteristics were analyzed.ResultsA total of 152 patients diagnosed with asthma, of whom 73% were women and 11% ex-smokers, were included in this study, with a mean age of 66 years. Only 10.5% of the participants had onset asthma past the age of 60. Regarding asthma severity, 74.3% were diagnosed with moderate persistent asthma, and 7.2% with severe persistent asthma. Eighty-four percent of the patients were treated with an inhaled corticosteroid (ICS) along with a long-acting β 2-adrenergic agent (LABA). More than half of the patients had two or more comorbidities simultaneously. Allergic comorbidities were the most frequent comorbidities, followed by arterial hypertension. Among allergic comorbidities, most patients presented allergies at the nasal level. There were no significant differences between the subpopulations of patients with late-onset asthma (LOA) and asthma with onset before the age of 60, i.e. early onset asthma (EOA) in most of their clinical characteristics. However, it was observed that EOA accounted for a higher percentage of patients with nasal allergies as compared to LOA (71% vs 46%, p < 0.05).It is worth mentioning that almost half of the patients with LOA had allergies at the nasal level.ConclusionThese results may provide a better understanding of the clinical characteristics of asthma in the elderly in Argentina, thus, enabling the development of future therapeutic strategies and a better quality of life for our elderly asthma patients.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and comorbidities of elderly asthmatics who attend allergy clinics

Yáñez¹,

Soria²,

Barayazarra

et al. 2018

asthma res and pract

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“…The clinical features of asthma in the elderly are very complex and quite distinct from the disease in young adults [40]. The prevalence of asthma in the elderly ranges from 4.5% to 12.7%, and includes both longstanding early-onset asthma and adult-onset disease [41,42].…”

Section: Asthma In the Elderlymentioning

confidence: 99%

Personalised medicine in asthma: from curative to preventive medicine

et al. 2017

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The concept of asthma has changed substantially in recent years. Asthma is now recognised as a heterogeneous entity that is complex to treat. The subdivision of asthma, provided by "cluster" analyses, has revealed various groups of asthma patients who share phenotypic features. These phenotypes underlie the need for personalised asthma therapy because, in contrast to the previous approach, treatment must be tailored to the individual patient. Determination of the patient's asthma phenotype is therefore essential but sometimes challenging, particularly in elderly patients with a multitude of comorbidities and a complex exposure history. This review first describes the various asthma phenotypes, some of which were defined empirically and others through cluster analysis, and then discusses personalisation of the patient's diagnosis and therapy, addressing in particular biological therapies and patient education. This personalised approach to curative medicine should make way in the coming years for personalised preventive and predictive medicine, focused on subjects at risk who are not yet ill, with the aim of preventing asthma before it occurs. The concept of personalised preventive medicine may seem a long way off, but is it really?

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“…Patients with long-standing asthma have worse and more frequent respiratory symptoms, an increased number of hospitalizations and emergency medical interventions, and lower parameters of lung function. 22 Park et al 23 established a prospective, observational cohort of elderly Korean patients with asthma to identify elderly patients with asthma with distinct clinical phenotypes. Four clusters of elderly patients with asthma were identified: 1) long duration of symptoms and marked obstruction of airways, 2) female dominance and normal lung function, 3) male dominance for smoking and reduced lung function, and 4) high body mass index and borderline lung function.…”

Section: Phenotype Of Allergic Asthma In the Elderlymentioning

confidence: 99%

Challenges in the management of severe allergic asthma in the elderly

Öztürk¹,

Iliaz²

2016

JAA

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Little is known about the features of asthma and allergy in the elderly. A significant number of elderly patients with asthma have uncontrolled and severe asthma. This review aims to provide an analysis of the literature on the assessment and phenotype of severe allergic asthma in the elderly. Gaps and pitfalls in diagnostic and therapeutic approaches, as well as management of severe allergic asthma in the elderly, are also discussed.

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Differences between asthma in young and elderly: Results from the COREA study

Abstract: EA and NEA have different compositional patterns underlying their clinical variables. These observations helped in understanding the differences between EA and NEA from the integrated view covering various clinical aspects.

Cited by 18 publications

References 24 publications

Clinical characteristics and comorbidities of elderly asthmatics who attend allergy clinics

Clinical characteristics and comorbidities of elderly asthmatics who attend allergy clinics

Personalised medicine in asthma: from curative to preventive medicine

Challenges in the management of severe allergic asthma in the elderly

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