Differences between amlodipine and lisinopril in control of clinic and twenty-four hour ambulatory blood pressures

Abstract

The anti-hypertensive efficacy of once-daily amlodipine (up to 10 mg) and lisinopril (up to 20 mg) were compared in terms of clinic and ambulatory blood pressure (BP) control, in an observer-blind, two-period crossover study. Following a 4-week placebo run-in period, patients underwent two active treatment phases each lasting 12 weeks and separated by a 4-week washout period. Sixty patients with a supine diastolic BP between 90 and 120 mm Hg were included, irrespective of whether or not they had received previous anti-hyper-

Add-On Effect of Bedtime Dosing of the .ALPHA.1-Adrenergic Receptor Antagonist Doxazosin on Morning Hypertension and Left Ventricular Hypertrophy in Patients Undergoing Long-Term Amlodipine Monotherapy

“…Among the dihydropyridine derivatives, amlodipine has a distinct pharmacokinetic profile with a long half life of 34 h; thus, single daily dosing enables steady-state plasma concentrations to be achieved (18). Clinical studies based on ambulatory blood pressure monitoring (ABPM) have confirmed that amlodipine is more effective in controlling morning blood pressure after awakening than other CCBs with short plasma half lives (19) or angiotensin converting enzyme inhibitors (20). However, we have previously observed that 19% of patients under longterm amlodipine monotherapy experience morning hypertension with an average morning systolic blood pressure (SBP) over 135 mmHg, despite the fact that their average evening SBPs are adequately controlled at below 135 mmHg (21).…”

Effects of long-acting ACE inhibitor (temocapril) and long-acting Ca channel blocker (amlodipine) on 24-h ambulatory BP in elderly hypertensive patients

“…7,14 In our study, amlodipine once daily in the morning reduced the BP level throughout the day and night in both dippers and non-dippers. In nondippers, night time and morning high BP were well reduced by amlodipine.…”

“…The same phenomenon was observed in a report comparing amlodipine and lisinopril. 7 We suggest three possible explanations for this phenomenon. First, the plasma half-life of temocapril (14.5-21.5 h) is shorter than that of amlodipine (35-48 h).…”

“…And there are few reports comparing these drugs in terms of diurnal BP variations. 7 We conducted this study to evaluate the effects of temocapril (a long-acting ACE inhibitor), and amlodipine (a long-acting CCB) on 24-h ambulatory BP under successful office BP control.…”

Cost per millimeter of mercury lowering is a measure of economic value for antihypertensive agents

“…Irbesartan proved more effective than losartan in two separate studies that used seated diastolic blood pressure as a primary efficacy endpoint [20,21]. Amlodipine reduced both supine systolic and diastolic blood pressure more than lisinopril [22].…”